Future office buildings are expected to be integrated with energy intensive, inherently DC components such as photovoltaic panels (PV), electric vehicles (EV), LED lighting, and battery storage. This paper conceptualizes the interconnection of these components through a 750 V DC nanogrid as against a conventional three-phase 400 V AC system. The factors influencing the performance of a DC-based nanogrid are identified and a comparative analysis with respect to a conventional AC nanogrid is presented in terms of efficiency, stability, and protection. It is proved how the minimization of grid energy exchange through power management is a vital system design choice. Secondly, the trade-off between stability, protection, and cost for sizing of the DC buffer capacitors is explored. The transient system response to different fault conditions for both AC and DC nanogrid is investigated. Finally the differences between the two systems in terms of various safety aspects are highlighted.