Comparison of Rabies Vaccines Grown on Duck Embryo and on Nervous Tissue

Gibbs, Frederic A.; Gibbs, Erna L.; Carpenter, P. R.; Spies, Harold W.

doi:10.1056/nejm196111162652008

Cited by 16 publications

(5 citation statements)

References 8 publications

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“…There is indirect evidence that the virus frequently affects the central nervous system (CNS) in the prodromal and early clinical stages of measles that is, frequent electroencephalographic abnormalities (Gibbs et al, 1959;Pampiglione, 1964) and cerebrospinal fluid (CSF) pleocytosis (Hanninen et al, 1980). Mental retardation, deafness, and motor deficits are the common sequelae of the resulting encephalomyelitis (Johnson et al, 2000).…”

Section: Discussionmentioning

confidence: 99%

Measles complications in a Nigerian hospital setting

Onoja¹

2013

Clin. Rev. Opinions

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In spite of active measles vaccination efforts in 2005 in southern Nigeria, re-emergence continues to occur. This study was carried out to ascertain the incidence of measles, severity, mortality and its complications, in order to enhance treatment and reduce under-five child mortality. Secondary data from the records in the measles ward of Oni Memorial Children's Hospital, Ibadan was used. The period under investigation was 2005 to 2008, following the catch-up and follow-up measles vaccination exercise. Four hundred children between the ages of 5 months and 14 years were clinically diagnosed with measles from 2005 to 2008, of which 124 (31%) had complications. Among those with complications, 70 (56.5%) mortalities were observed, and as the children approached 14 years of age, incidence of measles reduced to 0%. Measles is still a major childhood problem in the southern part of Nigeria, even as the burden is more in northern Nigeria. This will invariably hamper global measles mortality reduction initiatives and the attainment of the fourth millennium development goal of reduction of under-five child mortality by 2015, hence the need for a coordinated and strategic mass vaccination effort to target unimmunized children.

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Section: Discussionmentioning

confidence: 99%

Measles complications in a Nigerian hospital setting

Onoja¹

2013

Clin. Rev. Opinions

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“…Duck embryo vaccine, with its comparatively low content of nervous tissue, is a marked ad¬ vance over nervous-tissue vaccines in regard to freedom from neurological complications (9,10). This product is currently preferred by most practicing physicians and health officers, both for postexposure treatment of persons bit¬ ten by rabid animals and for preexposure vac¬ cination of high-risk groups.…”

Section: Discussionmentioning

confidence: 99%

Potency of Commercial Rabies Vaccine Used in Man

Dean¹,

Sherman²

1962

Public Health Reports (1896-1970)

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“…In view of the work of Gibbs et al (1959) it was agreed to study the E.E.G. patterns in patients with rubella, whether with or without complications.…”

Section: Chmentioning

confidence: 99%

“…Changes in the cerebrospinal fluid were found to be of little prognostic significance. Reports of electroencephalographic studies either in complicated or uncomplicated cases of rubella are few (Mitchell and Pampiglione, 1954;Gibbs et al, 1959).…”

mentioning

confidence: 99%