Comparison of Radiobiological Models for Radiation Therapy Plans of Prostate Cancer: Three-dimensional Conformal versus Intensity Modulated Radiation Therapy

Mesbahi, Asghar; Rasouli, Naser; Mohammadzadeh, Mohammad; Motlagh, Behnam Nasiri; Tekın, H.O.

doi:10.31661/jbpe.v9i3jun.655

Cited by 21 publications

(14 citation statements)

References 22 publications

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“…Comparison of radiobiological models between RC3D and IMRT shows that IMRT is more suitable for reducing bladder, rectal and digestive doses while offering more possibilities for dose escalation [15].…”

Section: Discussionmentioning

confidence: 99%

Conformational Radiotherapy of Prostatic Adenocarcinoma at the Dalal Jamm Hospital, Senegal—(Retrospective Analysis of a Series of 62 Cases)

Bâ¹,

Diallo²,

Sarr³

et al. 2020

JCT

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Aim: We endeavored to describe the epidemiological profile of prostatic cancer, and to evaluate its diagnostic and therapeutic aspects. Method: We conducted a descriptive retrospective study on the conformational radiotherapy of prostatic adenocarcinoma at the Dalal Jamm University Hospital, Senegal from June 2018 to December 2019. We included 62 consecutive patients. The average age of the patients was 68.9 years. The average consultation time was 7.6 months. Results: Symptom manifestation and high PSA triggered the diagnosis of cancer in 74.2% and 25.8% of patients, respectively. Symptoms: pollakiuria (72.3%), bone pain (8%) and erectile dysfunction (4.8%). The digital rectal examination: normal (33.8%), nodular (30.6%), induration (24.1%), and shielding (11.3%). The mean PSA level was 90.6 ng/ml. Histology: adenocarcinoma was the most common (98.6%). The Gleason score: <7 (45.1%), =7 (35.5%), and >7 (19.4%). The majority of patients were in the high-risk group (70.9%) and 7 patients (11.2%) were metastatic at diagnosis. Therapy: first radical prostatectomy (20.9%), first-line curative radiotherapy (67.8%), adjuvant (21%) and palliative radiotherapy in 7 patients (11.2%): patients having received palliative radiotherapy had an estimated decline in symptoms of 80%. Hormone therapy was performed in 88.8% of patients, with average duration of 12.5 months. After a mean follow-up of 15 months, 59 patients were alive, including 45 cases (81.8%) in complete remission; 3 patients with metastasis at the first visit (having received palliative radiotherapy) died. Conclusion: The collected data show a profile of prostate cancer that is specific to the sub-Saharan context in which the discovery is still late. Also in comparison to developed countries, the therapeutic means necessary to fight against this cancer are limited, even though How to cite this paper:

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Section: Discussionmentioning

confidence: 99%

Conformational Radiotherapy of Prostatic Adenocarcinoma at the Dalal Jamm Hospital, Senegal—(Retrospective Analysis of a Series of 62 Cases)

Bâ¹,

Diallo²,

Sarr³

et al. 2020

JCT

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“…We evaluated and compared the radiobiological results of four various IMRT techniques in different ranges of anatomical parameters. In the previous studies [4][5][6][7][8][9][10], comparison of IMRT radiotherapy techniques with other methods have been investigated from the perspective of radiobiological effects. Nevertheless, different IMRT techniques have not been conclusively compared.…”

Section: Discussionmentioning

confidence: 99%

“…Intensity modulated radiotherapy (IMRT), as a one of most usable techniques [3], is used to deliver prescribed dose to the target tissue and spare OARs from irradiation. The preference of IMRT on conventional and conformal techniques has been proven in previous studies [4][5][6][7]. In addition, IMRT has indicated similar or just a little worse radiobiological and dosimetric results in comparison with newer radiotherapy techniques, like the volumetric modulated radiotherapy, tomotherapy and intensity modulated arc therapy [8][9][10].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of various common prostate IMRT techniques based on estimated tumor control and normal tissue complication probabilities in correlation with patients anatomical parameters derived from the CT scans

Banaei

Hashemi

Bakhshandeh

et al. 2019

Polish Journal of Medical Physics and Engineering

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Background: The relationship between the prostate IMRT techniques and patients anatomical parameters has been rarely investigated. Objective: to evaluate various prostate IMRT techniques based on tumor control and normal tissue complication probability (TCP and NTCP) values and also the correlation of such techniques with patients anatomical parameters. Methods: Four IMRT techniques (9, 7 and 5 fields and also automatic) were planned on the CT scans of 63 prostate cancer patients. The sum of distances between the organs at risk (OARs) and target tissue and also their average joint volumes were measured and assumed as anatomical parameters. Selected dosimetric and radiobiological parameters (TCP and NTCP) values were compared among various techniques and the correlation with the above anatomical parameters were assessed using Pearsons' correlation. Results: High correlations were found between the dosimetric/radiobiological parameters of OARs with the joint volumes and with the distances between the OARs and target tissue in all the techniques. The TCP and complication free tumor control probability (P + ) values were decreased with increasing the joint volume and decreasing the distances between the OARs and target tissue (as poly-nominal functions). The NTCP values were increased with increasing the joint volumes and decreasing the distances (3-degree poly-nominal functions). For the low percent joint volumes (<20%) and high distances (>7 cm), The TCP, NTCP and P + showed no statistical differences between various techniques (P-value>0.07). However, 9 and 7 fields techniques indicated better radiobiological results (P-value<0.05) in almost other ranges (>20% joint volumes and <7 cm distances). Conclusion: Based on our results, it would be possible to compare radiobiological effects of various common IMRT techniques and choose the best one regarding to patients anatomical parameters derived from the CT scans.

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“…However, some producers have included radiobiological models in commercial TPS that use DVH curves in the treatment plan and biological parameters such as histologic type and characteristics of nearby healthy tissues to calculate tumor control probability (TCP) and normal tissue complication probability (NTCP). The radiobiological models included in the TPS software are based on the Poisson TCP model and the LKB model for the calculation of NTCP [9,14].…”

Section: Introductionmentioning

confidence: 99%

Implications of Radiosensitizer and Radioprotector Factors in Refining the Dose-Volume Constraints and Radiobiological Models

Mireștean¹,

Buzea²,

Iancu³

et al. 2021

Translational Research in Cancer

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Radiotherapy is a cornerstone of the modern treatment of many types of cancer, having both curative and palliative roles. It is estimated that more than half of cancer patients will need radiation therapy in the course of evolution. The goal of radiotherapy is to maximize tumor control, reducing adverse effects on normal tissues in close proximity at the same time. Improving the therapeutic ratio is the main goal of the efforts made to improve the technique and accuracy of the radiotherapy by using the targeting of the tumor volume with the help of the imaging guide and the dose conformation around the target volume. The use of the multi-leaf collimator (MLC) allowed a better coverage of the target volume in the irradiation field, thus reducing the unnecessary irradiation of healthy tissues. The use of radioprotective agents and radiosensitizers is another strategy to maximize the effect of radiotherapy. Recently, interest has focused on the design of irradiation protocols that exploit the differences in biology in terms of the response to irradiation between tumor cells and normal tissues.

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Comparison of Radiobiological Models for Radiation Therapy Plans of Prostate Cancer: Three-dimensional Conformal versus Intensity Modulated Radiation Therapy

Cited by 21 publications

References 22 publications

Conformational Radiotherapy of Prostatic Adenocarcinoma at the Dalal Jamm Hospital, Senegal—(Retrospective Analysis of a Series of 62 Cases)

Conformational Radiotherapy of Prostatic Adenocarcinoma at the Dalal Jamm Hospital, Senegal—(Retrospective Analysis of a Series of 62 Cases)

Evaluation of various common prostate IMRT techniques based on estimated tumor control and normal tissue complication probabilities in correlation with patients anatomical parameters derived from the CT scans

Implications of Radiosensitizer and Radioprotector Factors in Refining the Dose-Volume Constraints and Radiobiological Models

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