Comparison of regional cerebral blood flow in patients with anorexia nervosa before and after weight gain

Structural and functional differences in the cingulate cortex relate to disease severity in anorexia nervosa

“…Interestingly, previous single photon emission computed tomography studies have also revealed decreased perfusion, predominantly in the PCC, the pre-and postcentral gyrus, the precuneus and the lateral prefrontal cortex. 4,52 In the present fMRI experiment, a lack of BOLD activation suppression was observed in patients with anorexia nervosa in the PCC during the processing of painful thermal stimuli, indicating disturbed DMN activity. Thus, previous reports 8,51 and our results may point toward the possibility that the observed circumscribed structural deficits might represent the neural basis of the reported functional disturbances.…”

“…2 Functional imaging indicates that parietal activity at rest is generally decreased before and increased after treatment. 3,4 Symptom provocation further decreases parietal activity in currently ill patients. 5 It is tempting to relate parietal dysfunction to symptoms of anorexia nervosa because the parietal cortex is the brain region where both proprioceptive and visual information of one's own body are integrated and where appetitive and foodrelated behaviours are processed.…”

“…Both the anterior (ACC) and posterior cingulate cortices (PCC) have been identified to function abnormally in these individuals. 2,4,[7][8][9] The third prominent brain region supposed to play a major role in anorexia nervosa is the insula. [10][11][12] This part of the brain is involved in the processing of emotion, pain perception, interoception and cognitive functioning as well as in the regulation of bodily homeostasis.…”

Neuropsychological Impairments in Anorexia Nervosa: A Spanish Sample Pilot Study

“…With regards to functional and morphological changes in the brains of females with AN, some studies have affirmed that the hypoactivity found in the right parietal cortex of these patients (Delvenne, Goldman, Biver, et al, 1997;Delvenne, Goldman, De Maertelaer, & Lotstra, 1999;Delvenne, Goldman, De Maertelaer, et al, 1997;Delvenne et al, 1995;Nozoe et al, 1993Nozoe et al, , 1995 and the hypoactivity found in the anterior cingulated cortex (Kojima et al, 2005;Naruo et al, 2001) reverted after weight gain (Delvenne et al, 1996;Miller et al, 2004), while others found the opposite results (Kojima et al, 2005;Van Kuyk et al, 2009). The cerebral areas most commonly associated with impaired functioning in patients with AN are the parietal cortex, ventromedial prefrontal cortex, gyrus lingualis within the occipital cortex, medial prefrontal cortex, cerebellum, nucleus caudatus, and insula (Grunwald et al, 2001;Sachdev, Mondraty, Wen, & Gulliford, 2008).…”

Reduced salience and default mode network activity in women with anorexia nervosa

“…8 In addition, the increased SMN activation we observed in recovered women compared to those with anorexia corresponds with a previous finding of increased regional cerebral blood flow in the RPG in women with anorexia nervosa after, compared to before, treatmentrelated weight gain. 72 Favaro and colleagues 38 have suggested that SMN impairments in individuals with anorexia nervosa reflect dysfunctional processing of somatosensory information regarding body size perception. They found a significant correlation between body image measures and SMN activation.…”