1958
DOI: 10.1172/jci103645
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Comparison of Response to Intravenously Administered Sodium Tolbutamide in Mild Diabetic and Nondiabetic Subjects12

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1961
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Cited by 66 publications
(18 citation statements)
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“…After an additional 5-to 7-hour fast, after the glucose tolerance test, an intravenous tolbutamide test (14) was performed (1 g of sodium tolbutamide given in 1 minute), and venous blood samples were taken at 0, 20, and 30 minutes for glucose measurement.…”
Section: Methodsmentioning
confidence: 99%
“…After an additional 5-to 7-hour fast, after the glucose tolerance test, an intravenous tolbutamide test (14) was performed (1 g of sodium tolbutamide given in 1 minute), and venous blood samples were taken at 0, 20, and 30 minutes for glucose measurement.…”
Section: Methodsmentioning
confidence: 99%
“…Such delayed nadirs might have been anticipated in the three patients with the diabetic type of 30-minute response (33). In the others, the prolonged reductions were contrary to the usual experience in normal nondiabetic subjects (33,35). In R. H., W.…”
Section: Methodsmentioning
confidence: 84%
“…The pattern of blood-sugar response to the iv administration of 1.0 g sodium tolbutamide has been extensively documented (33)(34)(35). In nondiabetic subjects, an average maximal decline to 50 to 60% of pretest values is achieved in about 30 minutes, and restoration to blood sugar levels greater than 80% of pretest values occurs within 90 minutes.…”
Section: Methodsmentioning
confidence: 99%
“…The total daily amount was 1.5 grams and remained the same for both treatment schedules. On the third day after admission standard 1 g intravenous tolbutamide tolerance tests were performed [33]. .,' ,,,/ j'~ …”
Section: Subjectsmentioning
confidence: 99%