Comparison of responses to adrenomedullin and adrenomedullin analogs in the mesenteric vascular bed of the cat

Santiago, José A.; Garrison, Etoi; Purnell, William L.; Smith, R. E.; Champion, Hunter C.; Coy, David H.; Murphy, William A.; Kadowitz, Philip J.

doi:10.1016/0014-2999(94)00693-2

Cited by 60 publications

(33 citation statements)

References 10 publications

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“…AdM is mainly synthesized in medulla, and also synthesized in many tissues such as myocardium, lungs, central nervous system, endothelium, vascular smooth muscle cells, and adipose tissue (7). It is clear that the essential physiological function of AdM is vasodilatation in both systemic circulation (6,24,25) and pulmonary stratum (26). In our study, there were significant differences between control group and other groups of AdM levels of liver tissues (p<0.05).…”

Section: Resultssupporting

confidence: 50%

The investigation of relationship between adrenomedullin vascular growth endothelial factor in obese and calorie restricted rats

Yürekli

Culum

2016

Med Sci and Discov

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Section: Resultssupporting

confidence: 50%

The investigation of relationship between adrenomedullin vascular growth endothelial factor in obese and calorie restricted rats

Yürekli

Culum

2016

Med Sci and Discov

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“…We have previously determined the distribution of AM in lung and in malignancies of pulmonary origin (Martínez et al 1995). The main physiological action of AM appears to be vasodilatation, both in the systemic circulation (Santiago et al 1995;Kitamura et al 1993a;Nuki et al 1993) and in the pulmonary vascular bed (Nossaman et al 1995). Other actions include bronchodilatation (Kanazawa et al 1994), regulation of renal function (Ebara et al 1994), inhibition of hormone secretion Samson et al 1995;Yamaguchi et al 1995), neurotransmission (Allen andFerguson 1996), and mitogenic activity Withers et al 1996).…”

mentioning

confidence: 99%

Adrenomedullin Receptor Expression in Human Lung and in Pulmonary Tumors

Martı́nez

Miller

Catt

et al. 1997

J Histochem Cytochem.

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SUMMARY Adrenomedullin (AM) is a multifunctional regulatory peptide that stimulates cyclic AMP production in many target tissues and is highly expressed in the lung. Analysis of the distribution of the recently cloned AM receptor (AM-R) by non-radioactive in situ hybridization revealed abundant expression in the basal cells of the airway epithelium and Type II pneumocytes. The expression of AM-R in the two cell types involved in epithelial regeneration of the lung suggests that AM may be relevant in such functions as organ development, wound repair, and epithelial turnover. AM-Rs are also synthesized in vivo and in vitro by a variety of tumor cells that also express the ligand, suggesting the existence of an autocrine loop that may be involved in tumor growth stimulation. The present findings suggest that the AM/AM-R regulatory system plays a major role in respiratory physiology and lung carcinogenesis and that new functions for AM remain to be identified.

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“…However, adrenomedullin itself is unlikely to be suitable for such a role because it is a potent vasodilator. Our earlier investigations potentially addressed this problem by demonstrating osteotropic activity in adrenomedullin(27-52), a fragment that lacks the structural requirements for vasodilator activity (Santiago et al 1995, Eguchi et al 1994). The present study assesses the skeletal effects of daily systemic administration of this peptide in mice.…”

Section: Introductionmentioning

confidence: 99%

Systemic administration of adrenomedullin(27-52) increases bone volume and strength in male mice

Cornish

Callon

Bava

et al. 2001

Journal of Endocrinology

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Adrenomedullin is a 52-amino acid peptide first described in a human phaeochromocytoma but since been found to be present in many tissues, including the vascular system and bone. Because of its structural similarity to amylin and calcitonin gene-related peptide, both of which have actions on bone cells, we have previously assessed the effects of adrenomedullin on the skeleton, and found that it increases osteoblast proliferation in vitro and bone formation following local injection in vivo. The present study carries this work forward by assessing the effects on bone of the systemic administration of a fragment of this peptide lacking the structural requirements for vasodilator activity. Two groups of 20 adult male mice received 20 injections of human adrenomedullin(27-52) 8·1 µg or vehicle over a 4-week period and bone histomorphometry and strength were assessed.In the tibia, adrenomedullin(27-52) produced increases in the indices of osteoblast activity, osteoid perimeter and osteoblast perimeter (P<0·05 for both using Student's t-test). Osteoclast perimeter was not affected. There was a 21% increase in cortical width and a 45% increase in trabecular bone volume in animals treated with adrenomedullin(27-52) (P<0·002 for both). Assessment of bone strength by three-point bending of the humerus showed both the maximal force and the displacement to the point of failure were increased in the animals treated with adrenomedullin(27-52) (P<0·03 for both). There was also a significant increase in the thickness of the epiphyseal growth plate. No adverse effects of the treatment were noted.It is concluded that adrenomedullin(27-52) acts as an anabolic agent on bone. These findings may be relevant to the normal regulation of bone mass and to the design of agents for the treatment of osteoporosis.

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Comparison of responses to adrenomedullin and adrenomedullin analogs in the mesenteric vascular bed of the cat

Cited by 60 publications

References 10 publications

The investigation of relationship between adrenomedullin vascular growth endothelial factor in obese and calorie restricted rats

The investigation of relationship between adrenomedullin vascular growth endothelial factor in obese and calorie restricted rats

Adrenomedullin Receptor Expression in Human Lung and in Pulmonary Tumors

Systemic administration of adrenomedullin(27-52) increases bone volume and strength in male mice

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