Comparison of Retinal Vessel Diameter Between Open-Angle Glaucoma Patients With Initial Parafoveal Scotoma and Peripheral Nasal Step

Yoo, Eunjoo; Yoo, Chungkwon; Lee, Tae Eun; Kim, Yong Yeon

doi:10.1016/j.ajo.2016.11.012

Cited by 13 publications

(15 citation statements)

References 41 publications

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“…Yoo et al . reported smaller retinal arteriolar diameter in NTG patients with parafoveal scotoma 18 . Recently, foveal avascular zone (FAZ) have been demonstrated as the factor affecting visual function in glaucoma using OCTA 19 , 20 .…”

Section: Discussionmentioning

confidence: 90%

Effect of Macular Vascular Density on Central Visual Function and Macular Structure in Glaucoma Patients

Jeon

2018

Sci Rep

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In patients with glaucomatous parafoveal scotoma, evidence of compromised vascular circulation was commonly seen. The purpose of this study is to evaluate the relationship between macular vascular density (VD) and central visual function and structure in glaucoma patients. We enrolled 46 eyes of normal tension glaucoma (NTG) patients with parafoveal scotoma. All subjects underwent measurement of segmented macular thickness in each layer and optical coherence tomography angiography (OCTA) to assess VD of macula. Correlation coefficients of VD with structural parameters were identified and multivariate regression analyses were performed to verify factors affecting the MD of SITA 10-2. Superficial VD in NFL, GCL and IPL showed significant correlation with thickness of those layers, but deep VD in INL did not show meaningful correlation with any structural parameters. However, deep VD showed significant correlations with central visual field parameters such as MD of SITA 10-2. By multivariate regression analysis, the significant factors affecting central visual function were deep VD. Different multivariate regression models including segmented macular thicknesses were compared and R2 value was best for the model with deep VD, not containing superficial VD (R2 = 0.326, p = 0.001). Assigning subjects as worse or better visual functional group using regression line, deep VD of worse functional group was significantly lower than that of better group. In couclusion, decreased deep VD was an independent risk factor for central scotoma in addition to structural thinning. Taking both macular thickness and vascular circulation into acount, the deterioration of central visual function could be predicted more precisely.

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Section: Discussionmentioning

confidence: 90%

Effect of Macular Vascular Density on Central Visual Function and Macular Structure in Glaucoma Patients

Jeon

2018

Sci Rep

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“…One recent study showed that retinal arteriolar diameter is not significantly different in POAG with initial parafoveal scotoma than in those with initial peripheral nasal step (Yoo et al. ). One other study showed that the association between the retinal arteries diameters (measured using the retinal vessel analyzer) and MD was generally weak (Resch et al.…”

Section: Discussionmentioning

confidence: 99%

Retinal vessel phenotype in patients with primary open‐angle glaucoma

Chiquet

Gavard

Arnould

et al. 2019

Acta Ophthalmologica

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Purpose: To characterize the phenotype of retinal vessels using central retinal artery equivalent (CRAE), central retinal vein equivalent (CRVE), tortuosity and fractal dimension (FD) in primary open-angle glaucoma (POAG) subjects. Methods: This prospective case-control multicentre study included 61 POAG subjects and 61 controls matched for age, systemic hypertension and body mass index. Fundus images of the right eye were acquired using a non-mydriatic camera. Central retinal artery equivalent (CRAE), CRVE, arteriole-to-venule ratio, FD and tortuosity of the vascular network were measured using VAMPIRE software (Vessel Assessment and Measurement Platform for Images of the Retina). Primary open-angle glaucoma (POAG) patients underwent 24.2 sita-standard visual field and peri-papillary optical coherence tomography (OCT) examinations. Data were expressed as median and interquartile range (75-25th percentiles).Results: The control group was comparable to the POAG group for sex ratio, refraction and intraocular pressure. The mean CRAE and the mean CRVE were significantly lower in the POAG group than in the control group [150.5 (137.9; 157.1) lm versus 161.3 (154.0; 168.4) lm and 204.8 (190.1; 218.1) lm versus 233.5 (222.3; 246.9) lm, respectively; p < 0.001] and for fractal parameters as well. No significant difference was found for tortuosity between the two groups. There was a significant correlation between CRAE and retinal nerve fibre layer (RNFL) thickness (r = 0.27; p = 0.03). VAMPIRE parameters were not correlated with visual field indices.Conclusion: Primary open-angle glaucoma (POAG) was associated with a narrowing of arterial and venous retinal vessels, a higher arteriole-to-venule ratio and lower values of FD. The relationship between CRAE and RNFL thickness needs further investigation.

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“…4,5 More recent studies have shown that PFS is seen more frequently in patients with systemic vascular risk factors, such as systemic hypotension, migraine, and Raynaud's phenomenon, 6 and in eyes with narrower retinal vessels. 7 These findings suggest that specific patterns of glaucomatous VF loss may be associated with the underlying pathogenesis of glaucomatous optic neuropathy. However, the precise relationship between vascular mechanisms of optic nerve damage not related to IOP and the preferential occurrence of PFS remains to be determined.…”

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confidence: 86%

Central Visual Field Damage and Parapapillary Choroidal Microvasculature Dropout in Primary Open-Angle Glaucoma

Lee

Kim

et al. 2018

Ophthalmology

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Comparison of Retinal Vessel Diameter Between Open-Angle Glaucoma Patients With Initial Parafoveal Scotoma and Peripheral Nasal Step

Cited by 13 publications

References 41 publications

Effect of Macular Vascular Density on Central Visual Function and Macular Structure in Glaucoma Patients

Effect of Macular Vascular Density on Central Visual Function and Macular Structure in Glaucoma Patients

Retinal vessel phenotype in patients with primary open‐angle glaucoma

Central Visual Field Damage and Parapapillary Choroidal Microvasculature Dropout in Primary Open-Angle Glaucoma

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