Retinal vessel phenotype in patients with primary open‐angle glaucoma

Chiquet, C.; Gavard, Olivier; Arnould, Louis; Mautuit, Thibaud; MacGillivray, Tom; Bron, Alain M.; Semecas, Rachel; Trucco, Emanuele; Aptel, Florent

doi:10.1111/aos.14192

Cited by 15 publications

(22 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although primary open-angle glaucoma patients exhibited reduced values of fractal parameters, there was no significant difference in venous tortuosity. 22 The studies did not indicate a direct relationship between IOP and vascular complexity; however, Cheng et al 14 reported that IOP was not an influencing factor on FD in normal-tension glaucoma. In an experiment using pig eyes, the capillary tortuosity decreased significantly as IOP increased, 23 which is potentially the most direct evidence for the effect of IOP on vasculatures.…”

Section: Discussionmentioning

confidence: 98%

See 1 more Smart Citation

Ocular Factors of Fractal Dimension and Blood Vessel Tortuosity Derived From OCTA in a Healthy Chinese Population

Song

Cheng

et al. 2022

Trans. Vis. Sci. Tech.

View full text Add to dashboard Cite

Purpose To identify the ocular factors of microvascular fractal dimension (FD) and blood vessel tortuosity (BVT) of macula measured with optical coherence tomography angiography (OCTA) in a healthy Chinese population. Methods Healthy subjects without ocular disorders were recruited at Zhongshan Ophthalmic Center. The FD and BVT in the superficial capillary plexus (SCP) and deep capillary plexus (DCP) at the macula were obtained from OCTA images. The FD was calculated using the box-counting method, and the BVT was defined as the ratio of the actual distance between two points to the straight distance on the skeletonized image. Univariate and stepwise multivariate linear regression analyses were performed to identify the ocular factors of FD and BVT, and the results are presented as coefficients and 95% confidence intervals (CIs). Only the right eye of each subject was included. Results A total of 2189 healthy individuals (2189 eyes) were included with a mean age of 49.9 ± 13.2 years; 54.4% were female. In the multivariate model, the FD in the SCP was significantly associated with higher intraocular pressure (IOP) (β = 0.204; 95% CI, 0.073–0.335; P < 0.001), axial length (AL) (β = −0.875; 95% CI, −1.197 to −0.552; P < 0.001; R 2 = 0.26; root mean square error [RMSE] = 7.78). The FD in the DCP was significantly associated with best-corrected visual acuity (β = −6.170; 95% CI, −10.175 to −2.166; P = 0.003) and anterior chamber depth (β = −0.348; 95% CI, −0.673 to −0.023; P = 0.036; R 2 = 0.10; RMSE = 2.58). Superficial BVT was independently associated with IOP (β = −0.044; 95% CI, −0.079 to −0.009; P = 0.012) and AL (β = 0.097; 95% CI, 0.014–0.181; P = 0.022; R 2 = 0.15; RMSE = 2.02). Deep BVT was independently associated with IOP (β = −0.004; 95% CI, −0.009 to −0.0005; P = 0.028) and lens thickness (β = 0.036, 95% CI, 0.003–0.060; P = 0.028; R 2 = 0.07, RMSE = 0.25). Conclusions The IOP and AL were dependent ocular parameters variables of FD and BVT in the SCP in this healthy population. The FD in the DCP was also influenced by visual acuity and anterior chamber depth. These factors should be considered when microvascular geometrics are used in the future studies. Translational Relevance This work discovered the influence factors of OCTA geometrics parameters for further establishment of diagnostic model or method for glaucoma and other microvasculature-related ocular diseases.

show abstract

Section: Discussionmentioning

confidence: 98%

“…3 ). 22 The box-counting and BVT calculations were carried out using Image J software. Unqualified OCTA images were excluded from the analysis.…”

Section: Methodsmentioning

confidence: 99%

Ocular Factors of Fractal Dimension and Blood Vessel Tortuosity Derived From OCTA in a Healthy Chinese Population

Song

Cheng

et al. 2022

Trans. Vis. Sci. Tech.

View full text Add to dashboard Cite

show abstract

“…Effective quantitative retinal vascular metrics, such as vessel density, vessel perfusion and flow index, are available with OCT-A devices [4][5][6]. These fundus photograph and OCT-A retinal vascular metrics were shown to be correlated with the detection, severity and progression of various clinical eye diseases (e.g., diabetic retinopathy, vascular occlusion, glaucoma) [7][8][9][10][11]. Fundus and OCT-A features were associated not only with vascular ocular disorders, but also with systemic vascular diseases [12].…”

Section: Introductionmentioning

confidence: 99%

Using Artificial Intelligence to Analyse the Retinal Vascular Network: The Future of Cardiovascular Risk Assessment Based on Oculomics? A Narrative Review

et al. 2022

Self Cite

View full text Add to dashboard Cite

The healthcare burden of cardiovascular diseases remains a major issue worldwide. Understanding the underlying mechanisms and improving identification of people with a higher risk profile of systemic vascular disease through noninvasive examinations is crucial. In ophthalmology, retinal vascular network imaging is simple and noninvasive and can provide in vivo information of the microstructure and vascular health. For more than 10 years, different research teams have been working on developing software to enable automatic analysis of the retinal vascular network from different imaging techniques (retinal fundus photographs, OCT angiography, adaptive optics, etc.) and to provide a description of the geometric characteristics of its arterial and venous components. Thus, the structure of

show abstract

“…VAMPIRE has been used in several studies on retina biomarkers for lacunar stroke, cognition, dementia, hypertension, and cardiovascular diseases among others [ 4 ]. More recently, VAMPIRE has been used to investigate the retinal vessel phenotype in ocular disease, such as nonarteritic ischemic optic neuropathy and glaucoma [ 5 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

Retinal Vessel Phenotype in Patients with a History of Retinal Vein Occlusion

et al. 2021

Self Cite

View full text Add to dashboard Cite

Introduction: The aim of the study was to estimate the phenotype of retinal vessels using central retinal artery equivalent (CRAE), central retinal vein equivalent (CRVE), tortuosity, and fractal analysis in the unaffected contralateral eye of patients with central or branch retinal vein occlusion (CRVO or BRVO). Methods: Thirty-four patients suffering from CRVO, 15 suffering from BRVO, and 49 controlled matched subjects had a fundus image analyzed using the VAMPIRE software. The intraclass correlation coefficient and a Bland-Altman plot were done for the reproducibility study. Results: There was a lack of evidence of difference between the control group and the CRVO group for CRAE (p = 0.06), CRVE (p = 0.3), and arterio-venule ratio (AVR, p = 0.6). Contralateral eyes of CRVO exhibited a significantly higher arterial and minimum arterial tortuosity values (p = 0.012), as compared with control eyes. Contralateral eyes of patients with a history of BRVO had a significantly higher CRAE (p = 0.02), AVR (p = 0.006), and minimal arterial tortuosity (p = 0.05). Fractal analysis showed that contralateral eyes of BRVO had higher values of fractal parameters (D0a, p = 0.005). Conclusion: This study suggests that CVRO or BRVO is not triggered by the same retinal vascular phenotypes in the contralateral eye. The morphology of retinal vasculature may be associated with the occurrence of RVO, independently of known risk factors.

show abstract

Retinal vessel phenotype in patients with primary open‐angle glaucoma

Cited by 15 publications

References 30 publications

Ocular Factors of Fractal Dimension and Blood Vessel Tortuosity Derived From OCTA in a Healthy Chinese Population

Ocular Factors of Fractal Dimension and Blood Vessel Tortuosity Derived From OCTA in a Healthy Chinese Population

Using Artificial Intelligence to Analyse the Retinal Vascular Network: The Future of Cardiovascular Risk Assessment Based on Oculomics? A Narrative Review

Retinal Vessel Phenotype in Patients with a History of Retinal Vein Occlusion

Contact Info

Product

Resources

About