Comparison of salivary fluoride concentrations after administration of a bioadhesive slow-release tablet and a conventional fluoride tablet

Bottenberg, Peter; Cleymaet, Roberto; Muynck, C. De; Remon, Jean Paul; Coomans, Danny; Slop, D.

doi:10.1111/j.2042-7158.1992.tb05496.x

Cited by 19 publications

(8 citation statements)

References 12 publications

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“…The fact that the mouth rinse raised F concentrations more than tablets or toothpaste indicates that the distribution in the oral cavity is more complete and/or the retention of the solution by oral tissues is stronger. When it comes to the F concentration and the duration of elevated F concentrations during the daytime use of F, the results in this study confirm previous investigations [Bottenberg et al, 1992;Ekstrand, Seppä et al, 1997]. There are only a few reports of duration and concentrations of F after using F products during a period of sleep.…”

Section: Discussionsupporting

confidence: 81%

“…Rinsing with 1,000 ppm F leads to an elevated F concentration in dental plaque for at least 3 h [Ekstrand, 1997]. Although sucking F tablets results in initially high F concentrations, this cannot be sustained for a longer period than 1 h [Bottenberg et al, 1992]. On the other hand, bio-adhesive tablets were able to elevate salivary F concentrations for up to 8 h [Bottenberg et al, 1998].…”

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confidence: 99%

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Fluoride Retention of a Mucosa Adhesive Paste Compared with Other Home-Care Fluoride Products

2008

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Home-care use of fluoride (F) requires a motivated individual and several F products rely on a person’s ability to follow instructions and to cooperate with the treatment. The aim of this crossover study was to investigate concentrations, distribution in the oral cavity and duration of the elevated F concentrations after using four F products: (1) a mucosa adhesive paste with 0.1% F, (2) a mouth rinsing solution with 0.2% NaF, (3) toothpaste containing 0.5% F and (4) a tablet with 0.75 mg F. Fourteen subjects used the four products in randomized order either during the daytime or just before going to bed. The F concentration was measured both in saliva and at interproximal sites. After 6 h of sleep, the F concentration after using the mucosa adhesive paste and the mouth rinse solution was high in saliva. In the interproximal area, the adhesive paste showed the highest values. During daytime use, all the products increased the F concentration, but only the mucosa adhesive paste and the rinsing solution elevated F in saliva for up to 2 h. In the interproximal area, the paste increased the F concentration most. In conclusion, this study showed that the mucosa adhesive paste and the mouth rinse solution led to higher F concentrations and for a longer time than tablets and toothpaste. For patients who are unable to comply with traditional F treatment, an F-containing adhesive paste therefore has the potential to be a useful vehicle. For individuals who are able to cooperate, a mouth rinse with an F solution is a simple, efficient and well-known method for preventing dental caries.

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Section: Discussionsupporting

confidence: 81%

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confidence: 99%

Fluoride Retention of a Mucosa Adhesive Paste Compared with Other Home-Care Fluoride Products

2008

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“…Comparable variation was obtained from the in-vivo release properties of various buccal controlled release devices. [21,22] Estimation of the amount of drug released through the determination of the amount of drug remaining in the recovered tablets was previously conducted by, Mumtaz and Ch'ng [22] for the buccal delivery of triamcinolone acetonide. Comparing in-vitro and in-vivo drug release profiles (Fig.…”

Section: Resultsmentioning

confidence: 99%

Mucoadhesive Delivery Systems. II. Formulation and In‐Vitro/In‐Vivo Evaluation of Buccal Mucoadhesive Tablets Containing Water‐Soluble Drugs

Nafee

Ismail

Boraie

et al. 2004

Drug Development and Industrial Pharmacy

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From the previous work (Part I), mucoadhesive formulae containing 5% CP/65% HPMC/30% lactose and 2% PC/68% HPMC/30% mannitol as well as formulae based on sodium carboxymethyl cellulose (SCMC) were selected. Medicated tablets were prepared using diltiazem hydrochloride (DZ) and metclopramide hydrochloride (MP) in two different doses (30 and 60 mg). The effect of drug and dose on the mucoadhesive properties and in-vitro drug release was evaluated. All formulae produced extended drug release (over 8 to 12 h). Polyacrylic acid based matrices (PAA) showed Fickian's diffusion release pattern for both drugs. SCMC ensured zero-order release for DZ, which deviated to anomalous behavior in case of MP. Doubling the dose significantly reduced the bioadhesion strength (p<0.05) with a slight improvement in drug release rate. The formulation of bilayer tablets containing drug-free layer and medicated layer enhanced the drug release without affecting the bioadhesive performance. The bilayer tablet formulated with 2% PC/68% HPMC/30% mannitol (PC2) was selected for studying the in-vivo metoclopramide release in four healthy volunteers. The tablet ensured controlled drug release for 12 h, in addition, good correlation (r=0.9398) was observed between in-vitro and in-vivo data. The effect of ageing on selected formulae containing DZ and MP, respectively, was studied. Storage at 40 degrees C and 75% relative humidity for 6 months didn't influence the mucoadhesive performance, however, an enhanced released rate was observed.

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“…8 In this study, we developed intranasal delivery systems of plasmid DNA using in situ gelling and various mucoadhesive polymers such as polycarbophil 9,10 and polyethylene oxide. 11,12 We report here that the plasmid DNA intranasally administered with in situ gelling and mucoadhesive polymer-based vehicles showed much higher absorption and prolonged nasal retention while exerting little toxicity to the nasal mucosa.…”

Section: Introductionmentioning

confidence: 95%

In situ gelling and mucoadhesive polymer vehicles for controlled intranasal delivery of plasmid DNA

Park

Yoon

et al. 2001

J. Biomed. Mater. Res.

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Nasal administration of plasmid DNA is emerging as a new route of delivery for therapeutic genes and DNA vaccines. To improve the intranasal absorption of plasmid DNA, we designed delivery systems composed of in situ gelling and mucoadhesive polymers. Poloxamers (Pol) were used to provide in situ gelling property. Polycarbophil (PC) or polyethylene oxide (PEO) was used as mucoadhesive polymers. The gelation temperatures of the formulations slightly decreased by the mucoadhesive polymers, but not by plasmid DNA. The in vitro release of plasmid DNA from the gels followed Fickian diffusion. The absorption of plasmid DNA varied with the contents and type of mucoadhesive polymers. Of vehicles, Pol/PC 0.2% showed the highest absorption with an area under the curve value 11-fold higher than saline, the conventional vehicle. The nasal retention of plasmid DNA was highly prolonged by mucoadhesive polymers. At 3 h postdose, the nasal tissue levels of plasmid DNA given in Pol/PC and Pol/PEO 0.8% were 10- and 40-fold higher relative to saline. The histopathology of nasal tissues was not altered after repeated dosing over 2 weeks. The mRNA expression of plasmid DNA delivered by Pol or Pol/PEO 0.4% was observed in the nasal tissues. These results indicate that the nasal absorption of plasmid DNA can be effectively and safely enhanced by using in situ gelling and mucoadhesive polymer-based vehicles.

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Comparison of salivary fluoride concentrations after administration of a bioadhesive slow-release tablet and a conventional fluoride tablet

Cited by 19 publications

References 12 publications

Fluoride Retention of a Mucosa Adhesive Paste Compared with Other Home-Care Fluoride Products

Fluoride Retention of a Mucosa Adhesive Paste Compared with Other Home-Care Fluoride Products

Mucoadhesive Delivery Systems. II. Formulation and In‐Vitro/In‐Vivo Evaluation of Buccal Mucoadhesive Tablets Containing Water‐Soluble Drugs

In situ gelling and mucoadhesive polymer vehicles for controlled intranasal delivery of plasmid DNA

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