Objective. To evaluate oral fluoride (F) retention after using fluoridated toothpastes, rinsing solutions and chewing sticks (Miswaks) in orthodontic patients with and without orthodontic appliances. Material and methods. Nine orthodontic patients, with a mean age of 16 years, were included in a randomized, cross-over, experimental study. Six different home-care F products, two NaF toothpastes (0.32% and 1.1%), two NaF mouthwash solutions (0.05% and 0.2%) and two NaFimpregnated Miswaks chewing sticks (0.05% and 0.5%), were used both during the orthodontic treatment and 1 week after debonding. Unstimulated whole saliva and approximal saliva were collected from two interdental sites, before and up to 60 min after using each product for 2 min. The retention of F was calculated as the area under the 60-min F-clearance curve (AUC). Results. In general, the F concentrations at the various sites were higher before than after debonding. Moreover, the products with a high F content (toothpaste, mouthwash and Miswaks) resulted in higher F retention than the corresponding products with a lower F content. In whole saliva, the highest AUC values were found in patients using 0.2% NaF mouthwash, followed by 1.1% NaF toothpaste (p < 0.05). In approximal saliva, the retention values were highest after using 0.5% NaF-impregnated Miswaks in patients wearing orthodontic appliances (p < 0.001). Conclusions. The insertion of fixed orthodontic appliances appears to favor oral F retention for all the tested home-care F products. In addition, products with a high F content increase oral F retention.