Objective:To determine the salivary fluoride levels after toothbrushing with dentifrices containing 458 ppm and 1000 ppm of fluoride and to compare salivary fluoride levels of two dentifrices at different intervals of time.Materials and Methods:In total, 50 children in the age group of 6-12 years were selected. The individuals were randomly divided into two groups using either 458 ppm or 1000 ppm fluoride dentifrice, respectively. Whole saliva samples were collected prior to brushing, immediately after brushing, and at subsequent intervals after brushing into sterile test tubes.Results:Data collected were evaluated using unpaired t-test. Salivary fluoride level following the use of 458 ppm fluoride dentifrice was significantly lower than the level found following the use of 1000 ppm dentifrice, but the levels were above the baseline values even after 1 h.Conclusion:There was considerable salivary fluoride retention after brushing with fluoride dentifrices.