Comparison of sedative effects of oral ketamine and Alprazolam in cat

Issabeagloo, Eilyad

doi:10.1016/j.ijpsycho.2008.05.318

Cited by 4 publications

(5 citation statements)

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“…A further possible outcome for subanaesthetic doses of ketamine effects that we did not find evidence for is the increased locomotion, as found in rats (Hetzler & Wautlet, 1985). An increase in complexity compared with baseline was found for prefrontal and motor cortices, thus, a connection between this regional increase of LZ complexity and putative increased motor activity could be proposed as a possible explanation, however, as reported in our previous publication using the same dataset (Castro‐Zaballa et al, 2019), the cats retained muscular tone but hyperlocomotion was not observed in our experiments, nor in previous studies in cats (Ambros & Duke, 2013; Issabeagloo et al, 2011).…”

Section: Discussionsupporting

confidence: 59%

“…Each cat was recorded daily for ∼30 days in order to obtain complete basal and treatment data sets. The animal retained muscular tone but hyperlocomotion was not observed in our experiments (Castro‐Zaballa et al, 2019), nor in previous studies in cats (Issabeagloo et al, 2011), an increase in motor activity was also absent in semirestricted condition, and ∼5 min following the injection of ketamine the animals lay down on the floor unable to stand up (i.e., an ataxia‐like effect), but responded to sound stimulus directing the gaze towards the sound source. In the absence of stimuli, the cats moved their head from one side to the other (i.e., a head‐weaving‐like behaviour, described in rodents, and defined as stereotypies characterized as lateral side‐to‐side movement of the head without locomotion).…”

Section: Methodssupporting

confidence: 49%

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Ketamine and sleep modulate neural complexity dynamics in cats

Pascovich

Castro-Zaballa

Mediano

et al. 2022

Eur J of Neuroscience

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There is increasing evidence that the level of consciousness can be captured by neural informational complexity: for instance, complexity, as measured by the Lempel Ziv (LZ) compression algorithm, decreases during anaesthesia and non‐rapid eye movement (NREM) sleep in humans and rats, when compared with LZ in awake and REM sleep. In contrast, LZ is higher in humans under the effect of psychedelics, including subanaesthetic doses of ketamine. However, it is both unclear how this result would be modulated by varying ketamine doses, and whether it would extend to other species. Here, we studied LZ with and without auditory stimulation during wakefulness and different sleep stages in five cats implanted with intracranial electrodes, as well as under subanaesthetic doses of ketamine (5, 10, and 15 mg/kg i.m.). In line with previous results, LZ was lowest in NREM sleep, but similar in REM and wakefulness. Furthermore, we found an inverted U‐shaped curve following different levels of ketamine doses in a subset of electrodes, primarily in prefrontal cortex. However, it is worth noting that the variability in the ketamine dose–response curve across cats and cortices was larger than that in the sleep‐stage data, highlighting the differential local dynamics created by two different ways of modulating conscious state. These results replicate previous findings, both in humans and other species, demonstrating that neural complexity is highly sensitive to capture state changes between wake and sleep stages while adding a local cortical description. Finally, this study describes the differential effects of ketamine doses, replicating a rise in complexity for low doses, and further fall as doses approach anaesthetic levels in a differential manner depending on the cortex.

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Section: Discussionsupporting

confidence: 59%

Section: Methodssupporting

confidence: 49%

Ketamine and sleep modulate neural complexity dynamics in cats

Pascovich

Castro-Zaballa

Mediano

et al. 2022

Eur J of Neuroscience

View full text Add to dashboard Cite

show abstract

“…A further possible outcome for subanesthetic doses of ketamine effects that we did not find evidence for is the increased locomotion, as found in rats (Hetzler & Wautlet, 1985). An increase in complexity compared to baseline was found for prefrontal and motor cortices, thus, a connection between this regional increase of LZ complexity and putative increased motor activity could be proposed as a possible explanation, however, as reported in our previous publication using the same dataset (Castro-Zaballa et al, 2019), the cats retained muscular tone but hyperlocomotion was not observed in our experiments, nor in previous studies in cats (Ambros & Duke, 2013;Issabeagloo et al, 2011).…”

Section: Discussioncontrasting

confidence: 59%

“…Each cat was recorded daily for ~30 days in order to obtain complete basal and treatment data sets. The animal retained muscular tone but hyperlocomotion was not observed in our experiments (Castro et al, 2019), nor in previous studies in cats (Issabeagloo et al, 2011), an increase in motor activity was also absent in semi-restricted condition, and ~5 min following the injection of ketamine the animals lay down on the floor unable to stand up (i.e., an ataxia-like effect), but responded to sound stimulus directing the gaze toward the sound source. In the absence of stimuli, the cats moved their head from one side to the other (i.e., a head-weaving-like behavior, described in rodents, and defined as stereotypies characterized as lateral side-to-side movement of the head without locomotion).…”

Section: Methodssupporting

confidence: 54%

Ketamine and sleep modulate neural complexity dynamics in cats

Pascovich

Castro-Zaballa

Mediano

et al. 2021

Preprint

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There is increasing evidence that level of consciousness can be captured by neural informational complexity: for instance, complexity, as measured by the Lempel Ziv (LZ) compression algorithm, decreases during anesthesia and non-rapid eye movement (NREM) sleep in humans and rats, when compared to LZ in awake and REM sleep. In contrast, LZ is higher in humans under the effect of psychedelics, including subanesthetic doses of ketamine. However, it is both unclear how this result would be modulated by varying ketamine doses, and whether it would extend to other species. Here we studied LZ with and without auditory stimulation during wakefulness and different sleep stages in 5 cats implanted with intracranial electrodes, as well as under subanesthetic doses of ketamine (5, 10, and 15 mg/kg i.m.). In line with previous results, LZ was lowest in NREM sleep, but similar in REM and wakefulness. Furthermore, we found an inverted U-shaped curve following different levels of ketamine doses in a subset of electrodes, primarily in prefrontal cortex. However, it is worth noting that the variability in the ketamine dose-response curve across cats and cortices was larger than that in the sleep-stage data, highlighting the differential local dynamics created by two different ways of modulating conscious state. These results replicate previous findings, both in humans and other species, demonstrating that neural complexity is highly sensitive to capture state changes between wake and sleep stages while adding a local cortical description. Finally, this study describes the differential effects of ketamine doses, replicating a rise in complexity for low doses, and further fall as doses approach anesthetic levels in a differential manner depending on the cortex.

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“…Rosemary (Rosmarinus officinalis L., Lamiaceae family) is a woody herb that grows wild in the Mediterranean region, but is also largely cultivated in many areas worldwide as a tasty culinary spice. It has also well-known medicinal uses, such as antimicrobial [1][2][3] or neuroprotective [4,5]. Rosemary's high medicinal interest is mainly due to its antioxidant potential brought by its high contents in terpenoids and phenolic derivatives [6][7][8][9].…”

Section: Introductionmentioning

confidence: 99%

HPLC-DAD-ESI+-MS phytochemical profiles of several Rosmarinus Officinalis accessions from spain as influenced by different environmental stress conditions

Boscaiu¹,

Spain²,

Vicente³

et al. 2019

Studia UBB Chemia

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Rosemary, a native Mediterranean plant is a well-known source of phytochemicals with antioxidant activity attributed mainly to diterpenoids and flavonoids. The aim of the study was to establish an accurate evaluation of the rosemary metabolite profiles from several accessions under changing environmental conditions (water stress and soil salinity) comparing two sampling seasons (summer vs. spring) from four different habitats in Eastern Spain. The methodology was based on the identification and the quantitative evaluation of phytochemicals (phenolic acid derivatives, flavonoids, diterpenes and triterpenes) by HPLC coupled with diode-array detection and electrospray ionization mass spectrometry (ESI +-MS). Phytochemical profiles were statistically compared by factorial ANOVA, cluster analysis, principal component analysis and univariate analysis (Pearson correlations), that allowed the discrimination between the extract composition in correlation to their habitat and stress conditions. Out of twenty-three compounds identified, the major ones were represented by diterpenoids (carnosic acid, carnosol and oxidized metabolites rosmanol, epirosmanol, rosmadial, rosmanol methyl ether) and flavonoids, which showed significant metabolic regulation induced by water stress. The main conclusion of the work is that the diterpene derivatives and their oxidized metabolites may be considered as optimal biomarkers of the environmental stress in Rosmarinus officinalis.

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Comparison of sedative effects of oral ketamine and Alprazolam in cat

Cited by 4 publications

References 0 publications

Ketamine and sleep modulate neural complexity dynamics in cats

Ketamine and sleep modulate neural complexity dynamics in cats

Ketamine and sleep modulate neural complexity dynamics in cats

HPLC-DAD-ESI+-MS phytochemical profiles of several Rosmarinus Officinalis accessions from spain as influenced by different environmental stress conditions

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