Comparison of serum and urinary calcium profile of immobilized and ambulant trauma patients

Yusuf, Moruf Babatunde; Ikem, IC; Oginni, LM; Akinyoola, AL; Badmus, Tajudeen A.; Idowu, Ademola A.; Orimolade, Ayodele Elkanah

doi:10.1016/j.bone.2013.09.001

Cited by 10 publications

(5 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…First, higher doses of GCs were given in the initiating stage of GC therapy in patients with MG. A previous study reported that 24‐hours urinary calcium excretion was significantly increased at day 7 and at days 30‐60 of initiating at least 10 mg/day of methylprednisolone or equivalent . Second, reduced activity would also contribute to hypercalciuria . As hypercalciuria was the most common identifiable metabolic risk factor for renal calcification and kidney stones, intensive monitoring of urinary calcium excretion was important in patients with MG receiving treatment with GCs.…”

Section: Discussionmentioning

confidence: 99%

Effects of alendronate and alfacalcidol on bone in patients with myasthenia gravis initiating glucocorticoids treatment

Guan

et al. 2018

Clinical Endocrinology

View full text Add to dashboard Cite

We demonstrated for the first time that treatment with alendronate combined with alfacalcidol significantly increased BMD, decreased bone turnover biomarker levels and reduced the occurrence of hypercalciuria in a large cohort of Chinese patients with MG who initiated treatment with glucocorticoids. However, treatment with alfacalcidol alone failed to prevent bone loss in patients with MG receiving glucocorticoid therapy.

show abstract

Section: Discussionmentioning

confidence: 99%

Effects of alendronate and alfacalcidol on bone in patients with myasthenia gravis initiating glucocorticoids treatment

Guan

et al. 2018

Clinical Endocrinology

View full text Add to dashboard Cite

show abstract

“…In a previous study, the content of urine calcium increased in patients with pelvic fracture that underwent skin traction within 3 weeks of fracture [ 20 ]. Yusuf et al showed that the level of calcium in blood and urine of trauma patients is significantly greater than baseline [ 6 ]. Similarly, the level of urine calcium in group A significantly increased at different time points during this study period, compared with group B.…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, there was a significant difference in the changes in urine calcium levels based on fracture location, fracture type and age, but not gender, in the present study. In a previous study, immobilised trauma patients had higher calcium content in serum during the 4 weeks under study, compared to ambulant trauma patients [ 6 ]. In this study, upper limb fracture patients seemed to be like immobilised trauma patients, and lower limb fracture patients seemed to be like ambulant trauma patients.…”

Section: Discussionmentioning

confidence: 99%

“…Additionally, a previous study showed that higher dietary calcium intake reduced the risk of fracture in older men and women [ 5 ]. However, other studies indicated that higher dietary calcium intakes increase the risk of urinary stones (2–13%) in fracture patients or long-term bedridden patients, compared with healthy populations [ 6 – 8 ]. In other words, the consequences of increased calcium intakes for patients with a fracture are uncertain.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The variation in urinary calcium levels in adult patients with fracture and surgical intervention

et al. 2017

View full text Add to dashboard Cite

BackgroundGenerally, a higher calcium diet is fed to fracture patients after surgery. However, recent studies have indicated that higher dietary calcium intakes increase the risk of urinary stones for fracture patients. Therefore, this study aimed to observe the variation in urinary calcium levels among fracture patients who underwent surgery, based on fracture type, fracture location, age and gender.MethodsA total of 768 subjects were enrolled in this study from 2012 to 2015 and were divided into 2 groups: group A (fracture patients who underwent surgery) and group B (normal patients without fracture). Urine samples were collected for a 24-h period (24-h urine), at multiple specific time points before and after surgery for group A, or after hospitalisation for group B. Subsequently, urine calcium was detected and the changes were evaluated according to fracture location, fracture type, age and gender, as well as the distribution of hypercalciuria.ResultsCompared with group B, the level of urine calcium in group A significantly increased at different time points during the study period (P < 0.05). There were significant differences in the changes in urine calcium levels according to fracture location, fracture type and age, but not gender. Further, there were more patients with hypercalciuria in group A at the different time points, compared with group B.ConclusionVariation in urinary calcium among fracture patients that underwent surgery was of a regular pattern and hypercalciuria was also found in these patients. Therefore, a high-calcium diet and calcium supplements should be used with caution in this patient population.

show abstract

“…Bone loss happens already during the first 4–6 weeks of immobilization (40,41). In addition, immobilization leads to hypercalcemia and subsequent hypercalciuria that strongly increased from week 1 to week 4 (42). The fact that immobilization-related bone loss happens within 4–6 weeks is another good indication of an adaptive program because it well fits into the time window of 6 weeks given by the total consumption time (see above).…”

Section: Other Pathways Of Inflammation-stimulated Bone Lossmentioning

confidence: 99%

Evolutionary medicine and bone loss in chronic inflammatory diseases—A theory of inflammation-related osteopenia

Straub

Cutolo

Pacifici

2015

Seminars in Arthritis and Rheumatism

View full text Add to dashboard Cite

Objective Bone loss is typical in chronic inflammatory diseases such as rheumatoid arthritis, psoriasis, ankylosing spondylitis, systemic lupus erythematosus, multiple sclerosis, inflammatory bowel diseases, pemphigus vulgaris, and others. It is also typical in transplantation-related inflammation and during the process of aging. While we recognized that bone loss is tightly linked to immune system activation or inflammaging in the form of acute, chronic active, or chronic smoldering inflammation, bone loss is typically discussed to be an “accident of inflammation”. Methods Extensive literature search in PubMed central. Results Using elements of evolutionary medicine, energy regulation, and neuroendocrine regulation of homeostasis and immune function, we work out that bone waste is an adaptive, evolutionarily positively selected program that is absolutely necessary during acute inflammation. However, when acute inflammation enters a chronic state due to the inability to terminate inflammation (e.g., in autoimmunity or in continuous immunity against microbes), the acute program of bone loss is a misguided adaptive program. Conclusions The article highlights the complexity of interwoven pathways of osteopenia.

show abstract

Comparison of serum and urinary calcium profile of immobilized and ambulant trauma patients

Cited by 10 publications

References 21 publications

Effects of alendronate and alfacalcidol on bone in patients with myasthenia gravis initiating glucocorticoids treatment

Effects of alendronate and alfacalcidol on bone in patients with myasthenia gravis initiating glucocorticoids treatment

The variation in urinary calcium levels in adult patients with fracture and surgical intervention

Evolutionary medicine and bone loss in chronic inflammatory diseases—A theory of inflammation-related osteopenia

Contact Info

Product

Resources

About