Comparison of Serum HIF-1α Levels in Swimming Athletes Before and After Hypoxic Non-Hypoxic Exercise

Abstract

The situation of lack of oxygen supply to cells and tissues is often not realized by many people (hypoxia). Hypoxia can occur in various situations in life. One of them is swimming sports. The main effect of hypoxia is the effect on the brain, so the body will do everything it can to restore the state of homeostasis. HIF-1α protein is a marker of hypoxic conditions that regulate the synthesis of many genes to maintain and restore body homeostasis from hypoxia to normoxia. This study was a descriptive study with a crosssectional design. The sample of this study were six swimming athletes with a 12-19 year age range who met the inclusion and exclusion criteria. The HIF-1α protein is measured by the ELISA method. Data were analyzed statistically. The results showed higher levels of HIF-1α after anaerobic exercise than the levels of HIF-1α before and after aerobic exercise. It is greatly influenced by the intensity of the exercise carried out. It proves that cellular adaptation to hypoxia is more stable in aerobic exercise, where the body's metabolism is more stable during aerobic exercise.

Serum Protein Total Determination After Hypoxic Swimming Exercises in Trained and Untrained Swimmers Using The Nanophotometric Method

“…Pada saat latihan fisik terjadi berbagai respon sistemik dan seluler yang melibatkan perubahan metabolik, imunologi dan hormonal (Schild et al, 2016). Syahrastani, et al (2020) dan Farma et al (2020) melaporkan bahwa meningkatnya ekspresi HIF-1a pada level protein setelah latihan renang hypoxic. Selain itu M. Schild et al (2016) juga melaporkan peningkatan respon inflamasi setelah latihan fisik.…”

“…Respon adaptif yang telah dibangun oleh seseorang yang terlatih sehingga lebih mampu mengatasi respon seluler lainnya seperti respon inflamasi. Latihan hypoxic termasuk pada latihan anaerob yang bertujuan melatih kemampuan anaerobik (Syahrastani et al, 2020).…”