Comparison of serum lipid management between elderly and non-elderly patients with and without coronary heart disease (CHD)

Abstract

Serum lipid management in patients aged ≥ 75 has not been precisely explored. We, therefore, compared the serum lipid management between the two age groups with and without coronary heart disease (CHD).We, therefore, retrospectively reviewed medical charts of patients who were hospitalized in the departments of internal medicine during a period of 14 months. Serum lipid goal attainment was explored by applying the lipid goals for patients aged < 75 to those aged ≥ 75.In 1988 enrolled patients, 717 subjects (36.1%) were aged ≥ 75. Among them, 41.3% and 32.4% of the patients had CHD, 44.2% and 41.0% were primary prevention at high-risk, and 14.5% and 14.6% were primary prevention at moderate-risk in patients aged ≥ 75 and aged < 75, respectively. Serum LDL-C goal achievement rates in CHD were 66.9% and 65.0% in patients aged ≥ 75 and < 75, respectively (p = 0.334). In the primary prevention at high-risk, these rates were 73.5% and 63.3%, in patients aged ≥ 75 and < 75, respectively (p = 0.001). They were 77.9% and 58.1% in primary prevention at moderate-risk aged ≥ 75 and < 75, respectively (p < 0.001). In CHD, lipid-lowering medication subscription rates were significantly lower in patients aged ≥ 75 (60.1%) than those aged < 75 (73.8%, p < 0.001).In conclusion, in CHD, serum lipid goal attainment was comparable between the two age groups although the lipid-lowering drugs were less frequently prescribed in patients aged ≥ 75. Without CHD, it was significantly better in patients aged ≥ 75 than those aged < 75 although the lipid-lowering drug subscription rates were comparable between the two age groups.

Human cytomegalovirus infection and coronary heart disease: a systematic review

“…Clinically, it is divided into stable CHD and acute coronary syndrome. Although epidemiological studies have shown that classical risk factors such as high blood lipids [ 13 – 15 ], high blood pressure [ 16 , 17 ], smoking [ 18 – 23 ], obesity [ 24 – 29 ], and diabetes [ 30 – 33 ] lead to CHD, its etiology is not fully understood. In recent years, these traditional risk factors have been effectively reduced, but the incidence of AS is still high [ 33 – 35 ].…”

Deficiency of Nardilysin in the Liver Reduces Serum Cholesterol Levels

“…Reduction in serum cholesterol levels have been shown to be effective to prevent ASCVD 1,2) ; however, serum LDL-C goal attainment was not necessarily desirable. 3,4) Serum LDL-C levels are mostly regulated by endocytosis of LDL via hepatic LDL receptors (LDLR). 5,6) Cell-surface expression of LDLR depends upon transcriptional activation by sterol responsible element binding protein 2 (SREBP2), as well as post-translational regulation (protein degradation) by pro-protein convertase subtilisinkexin type 9 (PCSK9) and inducible degrader of LDL receptor (IDOL), an E3-ubiquitin ligase, which are activated by SREBP2 and liver X receptor (LXR), respectively.…”