Comparison of serum Lp‐PLA2 levels in ischemic stroke patients with H‐type hypertension or non‐H‐type hypertension

Qiao, Jie; Zhou, KuiChen; Huang, Chao; Fu, Siwen; Xing, Yonghong; Zhang, Biao

doi:10.1002/jcla.23068

Cited by 11 publications

(5 citation statements)

References 31 publications

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“…As a high-risk factor for atherosclerotic vascular disease and cardiovascular disease, Lp-PLA2 has received more and more attention. Recent studies have found that the level of Lp-PLA2 is not only related to the formation of lipid atherosclerotic plaques, ischemic stroke and vascular inflammation, but also to the occurrence of coronary heart disease (Bonnefont-Rousselot, 2016;Qiao et al, 2020;Qin et al, 2020). Lipid metabolism plays an important regulatory role in the occurrence and development of cardiovascular and cerebrovascular diseases (Esenwa and Elkind, 2016;Zhang et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

Lipoprotein-Associated Phospholipase A2 Is a Risk Factor for Patients With Parkinson’s Disease

Liang

et al. 2021

Front. Neurosci.

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ObjectiveTo explore the association between lipoprotein-related phospholipase A2 (Lp-PLA2) and the risk of Parkinson’s disease (PD).MethodsA case-control study involving 58 hospitalized PD patients and 60 healthy controls was carried out. Serum Lp-PLA2 level was detected. According to the disease course and severity, PD patients were subdivided to analyze the clinical value of Lp-PLA2. Relationship between Lp-PLA2 and PD risk was analyzed by logistic regression. Diagnostic value of Lp-PLA2 in PD patients was investigated using receiver’s operator characteristic curves.ResultsLp-PLA2 level was significantly higher in the PD patients compared with the controls, and was significantly and positively correlated with the Hoehn-Yahr (H&Y) stage. The serum Lp-PLA2 level and H&Y stage of PD patients with a longer disease course were significantly higher than those with a shorter disease course. PD patients with milder conditions had significantly lower serum Lp-PLA2 levels than patients with severe conditions. Multivariable logistic regression analysis indicated higher Lp-PLA2 level was an independent risk factor of PD patients. Moreover, the area under the curve for Lp-PLA2 was 0.703, which was between those of homocysteine and serum amylase A.ConclusionTo our knowledge, this is the first study to show that increased level of Lp-PLA2 is associated with the risk of PD. Lp-PLA2 may be used for early detection of PD, and provides an effective intervention target for clinical treatment of PD.

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Section: Introductionmentioning

confidence: 99%

Lipoprotein-Associated Phospholipase A2 Is a Risk Factor for Patients With Parkinson’s Disease

Liang

et al. 2021

Front. Neurosci.

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“…By activating cytokines and adhesion factors, vascular endothelial cells become dysfunctional, thereby increasing blood pressure. ③ Lp-PLA2 promotes the release of inflammatory mediators, collagen deposition and fibroblast proliferation in inflammatory reaction sites, and platelet aggregation, which plays an anti-inflammatory and anti-atherosclerosis role and promotes the progress of HDP (16)(17)(18). As a marker of inflammatory reaction in the body, CRP can activate platelet activity, inhibit platelet activating factor, promote platelet release of arachidonic acid and platelet aggregation, and inhibit the binding of platelet activating factor and neutrophils, which plays a role in regulating inflammatory reaction (19).…”

Section: Discussionmentioning

confidence: 99%

Correlation of Blood Lipid and Serum Inflammatory Factor Levels With Hypertensive Disorder Complicating Pregnancy

et al. 2022

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PurposeTo explore the changes of blood lipid and serum inflammatory factors in pregnant women with hypertensive disorder complicating pregnancy (HDP) and the relationship with disease development.Methods107 pregnant women with HDP who had regular prenatal examination in our hospital from July 2018 to July 2021 were selected as the research objects. According to the severity of the disease, they were divided into gestational hypertension group, mild preeclampsia group and severe preeclampsia group. 30 healthy pregnant women who underwent prenatal examination in the same period were selected as the healthy group. Serum total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), lipoprotein-associated phospholipaseA2 (Lp-PLA2), C- reactive protein (CRP), interleukin -6 (IL-6), tumor necrosis factor-α (TNF-α) were measured. Receiver operating characteristic curve (ROC) was used to analyze the predictive value of blood lipid and serum inflammatory factors in pregnant women with HDP.ResultsThe levels of serum TC, TG and LDL-C increased with the progression of HDP, the level of serum HDL-C decreased with the progression of HDP (P < 0.05). The levels of serum Lp-PLA2, CRP, IL-6 and TNF-α increased with the progression of HDP (P < 0.05). The AUC of serum TC, TG, HDL-C and LDL-C levels for predicting HDP were 0.759, 0.854, 0.770 and 0.785, respectively. The AUC of serum Lp-PLA2, CRP, IL-6 and TNF-α levels for predicting HDP were 0.873, 0.991, 0.966 and 0.999, respectively.ConclusionThe levels of blood lipid and serum inflammatory factor are closely related to HDP, which has certain value in predicting the occurrence and development of HDP.

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“…Increased circulating LP-PLA2 levels can help predict increased risks of MI, stroke, and cardiovascular death. 26 Elevated serum Lp-PLA2 levels have been reported in patients with ischemic stroke, 27 , 28 and is an independent risk factor for AIS. 29 , 30 The Lp-PLA2 G994T gene polymorphism may be an independent risk factor for ischemic stroke in a Chinese population.…”

Section: Discussionmentioning

confidence: 99%

Negative correlation between early recovery and lipoprotein-associated phospholipase A2 levels after intravenous thrombolysis

Wang

Guo

et al. 2022

J Int Med Res

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Objective Lipoprotein-associated phospholipase A2 (Lp-PLA2) is considered a biomarker for systemic inflammation and the risk of myocardial infarction and stroke. However, little is known about the effect of acute vascular events on marker levels. The purpose of this study was to assess the potential association of early recovery with Lp-PLA2 levels in patients with acute ischemic stroke (AIS) after intravenous thrombolysis (IVT). Methods Forty-three consecutive AIS patients who had their first stroke and were hospitalized within 5 hours of the onset of stroke were enrolled. All patients were treated with IVT using alteplase or urokinase. Plasma Lp-PLA2 levels were measured within 24 hours after IVT. Variables that showed a significant association with Lp-PLA2 in univariate analysis were included in the multivariate ordered logistic regression model. Results Early recovery was associated with Lp-PLA2 levels after IVT, and Lp-PLA2 levels tended to decrease with increased probability of early recovery. This study is the first to report a negative correlation between early recovery and Lp-PLA2 levels after IVT. Conclusion Early recovery after IVT was negatively correlated with Lp-PLA2 A2 levels.

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Comparison of serum Lp‐PLA2 levels in ischemic stroke patients with H‐type hypertension or non‐H‐type hypertension

Cited by 11 publications

References 31 publications

Lipoprotein-Associated Phospholipase A2 Is a Risk Factor for Patients With Parkinson’s Disease

Lipoprotein-Associated Phospholipase A2 Is a Risk Factor for Patients With Parkinson’s Disease

Correlation of Blood Lipid and Serum Inflammatory Factor Levels With Hypertensive Disorder Complicating Pregnancy

Negative correlation between early recovery and lipoprotein-associated phospholipase A2 levels after intravenous thrombolysis

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