Comparison of serum oestrogen concentrations in post-menopausal women taking oestrone sulphate and oestradiol.

Anderson, Anne B. M.; Sklovsky, Edson; Sayers, Linda; Steele, Penelope A.; Turnbull, A. C.

doi:10.1136/bmj.1.6106.140

Cited by 39 publications

(6 citation statements)

References 13 publications

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“…The recent studies of Anderson et al (1978) have confirmed our own observations (Jacobs et al 1977) that there is no difference in plasma oestrone and oestradiol concentrations during treatment with piperazine oestrone sulphate or oestradiol valerate. In both studies any increase in plasma oestradiol levels after ingestion of either oestrogen preparation was always associated with a much greater increase of plasma oestrone levels.…”

Section: Endocrine Effectsof Postmenopausal Oestrogen Therapysupporting

confidence: 72%

Steroid Endocrinology after the Menopause: A Review

1979

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Section: Endocrine Effectsof Postmenopausal Oestrogen Therapysupporting

confidence: 72%

Steroid Endocrinology after the Menopause: A Review

1979

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“…Since Premarin does not contain any unconjugated equilin or estrone, our results indicate that equilin sulfate and estrone sulfate are absorbed from the gut and converted to circulating equilin and estrone, respectively. These results agree with earlier reports (12,20,21) that estrone sulfate is rapidly absorbed from the gut and converted to estrone and estradiol.…”

Section: Discussionsupporting

confidence: 95%

“…It has been shown previously (21) that after the oral administration of estrone sulfate (1.5 mg) to postmenopausal women, the serum levels of estrone sulfate were over 30 times the concentration of estrone in the same serum samples. Similarly, the pretreatment levels of estrone (30-50 pg/ml) were between 30-50 times lower than the level of estrone sulfate (1-2 ng/ml) in these postmenopausal women (21). It has also been reported (24) that in normal postmenopausal women, 85% of the total estrone present in the serum is estrone sulfate.…”

Section: Discussionmentioning

confidence: 89%

Radioimmunoassay of Plasma Equilin and Estrone in Postmenopausal Women after the Administration of Premarin*

Bhavnani

Sarda

Chung

et al. 1981

The Journal of Clinical Endocrinology & Metabolism

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A RIA for the measurement of plasma equilin (3-hydroxy-1,3,5-(10)7-estratetraen-17-one) and estrone in postmenopausal women and other estrogen-deficient women on exogenous equine estrogen replacement therapy is described. Antiserum against estriol-3,16,17-trihemisuccinate-HSA and high specific activity [2,4-3H]equilin and [6,7-3H]estrone were used in the assay procedure. Specificity of the assay was achieved by separation of equilin from estrone by chromatography on micro-Celite partition columns using silver nitrate as the stationary phase. The sensitivity of the standard curves for both equilin and estrone was 10-20 pg, and the smallest amount of estrone and equilin that could be measured accurately in the plasma was 250 pg/ml for both steroids. The coefficient of variation for both steroids ranged from 1-8%, over a range of 250-5000 pg/ml plasma. The interassay coefficients of variation for equilin and estrone were 4.6% and 2.4%, respectively. After the administration of 10 mg Premarin iv, maximum concentrations of 4 and 11.2 ng/ml for equilin and estrone, respectively, were obtained after 20 min. Thereafter, both steroids disappeared from the plasma gradually. When 10 mg Premarin were administered orally, equilin and estrone appeared in the blood gradually, and maximum levels of 560 and 1400 pg/ml were reached after 3 and 5 h for equilin and estrone, respectively. Equilin gradually disappeared, and by 24 h, only small amounts (125 pg/ml) were detectable. The levels of estrone declined more rapidly, though it was still detectable after 24 h. These preliminary results indicate that equilin sulfate is converted to circulating unconjugated equilin in a manner similar to the conversion of circulating estrone sulfate to estrone.

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“…Oestrone and oestriol are metabolites of 17p-oestradiol. High levels of oestrone and oestrone sulphate have been found after the administration of 17P-oestradiol valerate (Anderson et al, 1978) or micronized 17Poestradiol (Dada et al, 1978). But 17P-oestradiol also has a higher affinity for oestrogen receptor sites than oestrone (Siiteri, 1975) and thus the value of adding oestriol is questionable.…”

Section: Table I Main Reasons For Drop-out For All Patients and Monthmentioning

confidence: 99%

CLINICAL TRIAL OF a NEW ORAL CONTRACEPTIVE PILL CONTAINING THE NATURAL OESTROGEN 17β‐OESTRADIOL

ÅTedt¹,

Jeppsson²,

Liedholm³

et al. 1979

BJOG

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The natural oestrogen, 17P-oestradiol, has been shown not to depress fibrinolysis and apparently has less influence on liver function and lipid metabolism than ethinyl oestradiol, the synthetic oestrogen in conventional 'combined' oral contraceptive tablets. A triple-blind study was therefore made of 21 5 women during 2051 treatment cycles with oral contraceptives containing either (i) 4 mg of micronized 17p-oestradiol and 3 mg norethisterone (Netagen 403), (ii) 4 mg 17P-oestradiol plus 2 mg of oestriol and 3 mg norethisterone (Netagen 423) or (iii) 50 pg ethinyl oestradiol and 3 mg norethisterone (Netasyn). There were no pregnancies or thrombotic incidents. The numbers discontinuing treatment were about the same in the three groups, the main reasons being intermenstrual spotting in those on Netagen 423, amenorrhoea and weight gain in those on Netagen 403 and nausea and weight gain in those on Netasyn. The natural oestrogen showed promise as a new and safe component of the 'combined' pill.

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Comparison of serum oestrogen concentrations in post-menopausal women taking oestrone sulphate and oestradiol.

Cited by 39 publications

References 13 publications

Steroid Endocrinology after the Menopause: A Review

Steroid Endocrinology after the Menopause: A Review

Radioimmunoassay of Plasma Equilin and Estrone in Postmenopausal Women after the Administration of Premarin*

CLINICAL TRIAL OF a NEW ORAL CONTRACEPTIVE PILL CONTAINING THE NATURAL OESTROGEN 17β‐OESTRADIOL

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