Comparison of serum, salivary, and rapid whole blood diagnostic tests for Helicobacter pylori and their validation against endoscopy based tests.

Diagnosis ofHelicobacter pyloriInfection in Children: Comparison of a Salivary Immunoglobulin G Antibody Test with the [13C]Urea Breath Test

“…Noninvasive diagnosis of H. pylori infection can be done by measuring specific anti-H. pylori immunoglobulin G (IgG) antibodies in serum or saliva with an enzyme-linked immunosorbent assay (IgG-ELISA), with the [ 13 C]urea breath test ([ 13 C]UBT), and with an enzyme immunoassay (HpSA) for antigens in stools (3, 12-14, 16-18, 21-25). Whole saliva as a test sample is easily accessible, and despite some less encouraging results with H. pylori testing (9,19,23), some studies seem to be promising (1,6,10,11,15).…”

Valor Diagnóstico da Saliva em Doenças Orais e Sistêmicas: Uma Revisão de Literatura

“…O método da reação em cadeia da polimerase (PCR) pode ser utilizado em fluidos bucais como fonte de DNA microbiano para detectar viroses (ex. vírus herpes associado com sarcoma de Kaposi) e bactérias, como por exemplo, Helicobacter pylori que é associado com gastrites, úlceras pépticas e possível câncer de estômago (KOELLE et al, 1997;REILLY et al, 1997).…”

“…Na pesquisa das proteínas presentes na saliva, em virtude da mistura que ocorre na cavidade oral entre produtos do hospedeiro e patógenos, podem-se identificar agentes biológicos específicos causadores de doenças virais, bacterianas e fúngicas, através do estudo de imunoglobulinas específicas pelo método ELISA ou por métodos de identificação direta desses microorganismos. Além disso, a saliva serve para identificação de marcadores biológicos importantes no diagnóstico e prognóstico de neoplasias malignas (AZEN, 1989;KOELLE et al, 1997;REILLY et al, 1997;SPICHER et al, 2001;FRANZMANN et al, 2005).…”

Salivary Diagnostics, Current Reality and Future Prospects

“…Today, it is possible to identify, for example, the herpes virus associated with Kaposi's sarcoma and the presence of bacteria such as Helicobacter pylori, which is associated with gastritis, peptic ulcers and possible stomach cancer [11,12]. Studies conducted in order to detect immunoglobulin M (IgM) against rubella showed 96% specificity when compared to standard considered as ideal test blood serum, which means that the use of saliva for epidemiological surveillance and control of this virus can be valid [24,25].…”

“…Saliva was used for a long time as a method to monitor the caries risk, being used as biological environment extremely useful as buffering capacity and microbiological evaluation. Today, it is an object of detailed study for the diagnosis of systemic diseases that affect the function of the salivary glands and saliva composition, for example, Sjögren's syndrome, alcoholic cirrhosis, cystic fibrosis, sarcoidosis, diabetes mellitus and adrenal cortex diseases [11,12]). …”