Comparison of serum uric acid levels between Japanese with and without metabolic syndrome

Numata, Takeyuki; Miyatake, Nobuyuki; Wada, Jun; Makino, Hírofumi

doi:10.1016/j.diabres.2007.10.031

Cited by 31 publications

(33 citation statements)

References 16 publications

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“…The current study found an independent association between hyperuricemia and MetS. This is consistent with previous studies [51] [52]. The underlying mechanisms of the association between serum uric acid level and MetS remain poorly understood.…”

Section: Discussionsupporting

confidence: 82%

Prevalence of Hyperuricemia among Hospitalized Elderly Patients and Its Association with Metabolic Syndrome

Rahman¹

2014

AAR

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There are few data available on the prevalence of hyperuricemia among elderly and its possible association with metabolic syndrome (MetS) so the aim of this study was to assess prevalence of hyperuricemia among hospitalized elderly patients as well as to assess its association with MetS. Cross sectional data from 200 hospitalized elderly patients were analyzed and the results were as follows: the prevalence of hyperuricemia was 21.0% in elderly men and 15.1% in elderly women. Multivariate logistic regression analysis revealed that BMI ≥ 30 (p = 0.031, OR = 1.1), hypertension (p = 0.019, OR = 1.8), high triglycerides level (p = 0.018, OR = 2.9) and hyperuricemia (p = 0.023, OR = 3.7) were independently associated with MetS. The study concluded that the prevalence of hyperuricemia among hospitalized elderly patients was 21.0% in elderly men and 15.1% in elderly women. There was an independent association between hyperuricemia and metabolic syndrome.

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Section: Discussionsupporting

confidence: 82%

Prevalence of Hyperuricemia among Hospitalized Elderly Patients and Its Association with Metabolic Syndrome

Rahman¹

2014

AAR

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“…Furthermore, hyperuricemia could, in turn, worsen insulin resistance via effects on endothelial NO [22,23] and potentially create a vicious cycle.…”

Section: Discussionmentioning

confidence: 99%

“…This finding of a relationship between hyperuricemia and MetS (with some of its main components) is probably due to the unifying underlying pathogenetic mechanism of insulin resistance, which with its associated hyperinsulinemia increases circulating uric acid levels possibly through one or more of: enhanced insulin action with decreased renal excretion of uric acid and increased whole-body uric acid production [20]; enhanced activity of the hexose monophosphate shunt with increased purine biosynthesis and turnover [21]; presence of hypertension and possibly decreased renal blood flow and microischemia, increased renal lactate secretion, and reduced renal uric acid excretion [22]. Furthermore, hyperuricemia could, in turn, worsen insulin resistance via effects on endothelial NO [22,23] and potentially create a vicious cycle.…”

Section: Discussionmentioning

confidence: 99%

Determinants of Blood Uric Acid Levels in a Dyslipidemic Arab Population

Al-Meshaweh

Jafar²,

Asem³

et al. 2011

Med Princ Pract

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Objectives: The objective of this study was to explore the relationships between circulating uric acid and lipid levels and components of the metabolic syndrome (MetS) in Arab dyslipidemic patients, a group already at high coronary artery disease risk. Subjects and Methods: The medical records of 1,229 subjects (632 men, 597 women) referred for treatment of dyslipidemia and followed up for at least 12 months were reviewed. Serum levels of uric acid and lipids (total cholesterol, triglycerides, low-density lipoprotein, high-density lipoprotein) and other variables in the National Cholesterol Education Program ATP III criteria definition of MetS were assessed at initial presentation and every 4– 6 months, under specific lipid-lowering treatment (statins and/or fibrates), in each of the subjects. Their respective associations were explored by appropriate logistic regression techniques with control for confounding risk factors, including age, gender and body mass index. Results: 306 subjects (24.9%) of the study population were hyperuricemic; they were more likely to be men, obese and diabetic. Also the serum uric acid level (mean ± SD) was greater in men with MetS compared with men without (377.0 ± 98.0 vs. 361.6 ± 83.1 µmol/l, p < 0.05), an observation not reproduced in women. Uric acid levels had significant associations with the presence of fasting hyperglycemia, hypertension and large waist circumference (WC) in men, but only with large WC in women. With statin treatment, uric acid levels decreased by 10% within 1 year of treatment; with fibrates, uric acid levels remained unchanged or slightly increased. Conclusion: The data showed that hyperuricemia is common in dyslipidemic patients in Kuwait, where its important determinants are male sex, obesity, diabetes and statin treatment.

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“…Therefore, it has been proposed that uric acid itself ,except from renal functions, is an indicator of endothelial injury (20,21). Researches conducted revealed significantly high uric acid levels in metabolic syndrome patients (22,23).…”

Section: Discussionmentioning

confidence: 99%

Relationship between Metabolic Syndrome and Inflammation in Peritoneal Dialysis Patients

Borazan¹,

Uçar

Gürsu

et al. 2012

Eur J Inflamm

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We aimed to investigate the relationship between inflammation and metabolic syndrome as defined by the National Cholesterol Education Program Adults Treatment Panel III (NCEP-ATP III) diagnostic criteria in peritoneal dialysis patients. Ninety-four patients treated with peritoneal dialysis were included in the study. Patients' age, sex, weight, waist circumference, arterial blood pressure, fasting blood glucose, total cholesterol, LDL-cholesterol, HDL-cholesterol, triglycerides, C-reactive protein, albumin, uric acid and fibrinogen levels were recorded. Fourty-one patients diagnosed with metabolic syndrome and 53 peritoneal dialysis patients without metabolic syndrome were identified. In the metabolic syndrome group mean decrease in serum albumin and mean increase in C-reactive protein and fibrinogen was significantly different from the other group (p 0.05). Peritoneal dialysis patients with metabolic syndrome should also be assessed for inflammation.

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Comparison of serum uric acid levels between Japanese with and without metabolic syndrome

Cited by 31 publications

References 16 publications

Prevalence of Hyperuricemia among Hospitalized Elderly Patients and Its Association with Metabolic Syndrome

Prevalence of Hyperuricemia among Hospitalized Elderly Patients and Its Association with Metabolic Syndrome

Determinants of Blood Uric Acid Levels in a Dyslipidemic Arab Population

Relationship between Metabolic Syndrome and Inflammation in Peritoneal Dialysis Patients

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