Prevalence of Hyperuricemia among Hospitalized Elderly Patients and Its Association with Metabolic Syndrome

Rahman, Tomader Taha Abdel

doi:10.4236/aar.2014.34043

Cited by 4 publications

(1 citation statement)

References 59 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…В одном из относительно недавних исследований с участием более 5 тысяч лиц пожилого возраста гиперурикемия обнаружена у 9,5 % пациентов 60 лет и старше, а в группе больных старше 80 лет этот показатель достигал уже 22 % [10]. В египетском исследовании распространенность гиперурикемии у больных в возрасте от 60 до 70 лет составила 11,1 %, в то время как у пациентов старше 80 лет -48 % [12].…”

Section: Discussionunclassified

Features of metabolic disorders in centenarians

Topolyanskaya

Елисеева²,

Turna³

et al. 2022

Medicinskij alfavit

View full text Add to dashboard Cite

Aim: to study the features of purine, lipid and carbohydrate metabolic disorders in patients with coronary artery disease over 90 years old (centenarians).Materials and methods. The study enrolled 225 patients over 90 years, hospitalized with coronary artery disease. The majority of patients (67.6%) were women. The mean age of the patients reached 92.5+2.2 years (from 90 to 106 years).The blood levels of uric acid, lipids, glucose and body mass index were determined.Results. Obesity was registered in 31.5% of patients, grade III obesity – in 1 patient. Overweight was observed in 39.1% of patients, normal body mass index (BMI) – in 28.9%. An increase in the blood concentration of triglycerides was determined in 11.2% of patients. A decrease in the level of high-density lipoprotein (HDL) cholesterol was registered in 12.7% of patients. The blood concentration of low-density lipoprotein cholesterol (LDL) less than 2.0 mmol/l was observed in 23.3% of cases. Dyslipidemia was registered more often in women (p=0.02). Hyperuricemia was found in 37.3% of patients – in 41.4% of women and 28.8% of men (p=0.04). Elevated fasting blood glucose levels were determined in 23.1% of patients, but only 0.9% of patients had glucose levels above 14 mmol/l.Conclusion. The study results indicate some features of metabolic disorders in centenarians with coronary artery disease. Most of the patients were obese or overweight. Frequent hyperuricemia was registered, but relatively low levels of atherogenic lipids and glucose.

show abstract

Section: Discussionunclassified

Features of metabolic disorders in centenarians

Topolyanskaya

Елисеева²,

Turna³

et al. 2022

Medicinskij alfavit

View full text Add to dashboard Cite

show abstract

Hyperuricemia and Cardiovascular Diseases in Very Elderly Patients with Coronary Artery Disease

Topolyanskaya

Vakulenko

Semashkova

et al. 2019

SN Compr. Clin. Med.

View full text Add to dashboard Cite

There are few data available on the prevalence of hyperuricemia and its possible association with cardiovascular diseases among the very elderly population. The main part of this study enrolled 320 very elderly hospitalized patients (aged 86.4 ± 5.0 years; females, 78.1%; males, 21.9%) with coronary artery disease (CAD) and arterial hypertension (AH). The second part of the study involved 48 patients younger than 60 years, who were hospitalized with CAD diagnosis for coronary angiography study. Patients with gout were excluded from analysis. Hyperuricemia was defined as serum uric acid (SUA) more than 340 μmol/l in women and 420 μmol/l in men. Elevated serum uric acid (SUA) levels were detected in 37.4% of 320 elderly patients. Hyperuricemia was significantly more common in women (in 41.5% of cases) than in men (in 25%) (p = 0.02). In the group of very elderly patients, there was a clear correlation between hyperuricemia and clinically significant chronic heart failure (OR = 5.0; 95% CI = 2.4-10.7; p < 0.0001), as well as with stroke in history (OR = 1.9; 95% CI = 1.0-3.4; p = 0.03). Hyperuricemia remained significant risk factor of heart failure in the multiple regression analysis (p < 0.001). Atrial fibrillation was significantly more frequently diagnosed in patients with hyperuricemia compared with patients with normal levels of uric acid (OR = 2.2; 95% CI = 1.3-3.6; p = 0.001). A pronounced positive correlation was found between the SUA levels and the diameter of the left atrium (r = 0.3; p = 0.000003). In the group of 48 CAD patients under 60 years of age, hyperuricemia was significantly associated with myocardial infarction (OR = 8.8; 95% CI = 2.0-38.9; p = 0.002) and chronic heart failure (OR = 6.9; 95% CI = 1.8-26.3; p = 0.003). In general, the obtained results indicate a significant prevalence of hyperuricemia in people with CAD. A significant relationship between the increased SUA levels and the development of some cardiovascular diseases was found.

show abstract

Egyptian consensus on treat-to-target approach of gout: evidence-based clinical practice guidelines for the management of gout

Miedany

Gadallah

Mansour

et al. 2022

Egypt Rheumatol Rehabil

View full text Add to dashboard Cite

Introduction New therapies, management approaches, and evidence regarding the management of gout have become available over the past years. This triggered the need for an updated recommendation for gout management. Through an up-to-date consensus evidence-based clinical practice guideline for the management of gout including recommendations for management of gout flares, optimum usage of urate lowering therapy for chronic gout, as well as patient education and lifestyle guidance. A wide systematic literature review was performed, and evidence-based recommendations were extrapolated, based on 16-key questions identified according to population, intervention, comparator, and outcomes (PICO) approach. These were evaluated by a panel consisted of 17 rheumatology experts via online surveys over a 2-round Delphi process. The purpose of this study is to offer an updated, consensus-evidence-based, and in the meantime patient-focused, expert recommendations for the treat-to-target approach of gout management. Results Results revealed that after round 2 ended, a total of 30-recommendation items, categorized into 10 domains, were obtained. Agreement with the recommendations (rank 7–9) ranged from 90 to 100%. Consensus was reached (i.e., ≥ 75% of respondents strongly agreed or agreed) on the wording, the grade of recommendation, and level of evidence of all the 30 clinical standards identified by the scientific committee. Conclusions This guideline provides updated evidence-based recommendations for the prevention and treatment of acute as well as chronic gout. This guideline provides an approach for physicians and patients making decisions on the management of gout. It will also facilitate improvement and uniformity of care.

show abstract

Prevalence of Hyperuricemia among Hospitalized Elderly Patients and Its Association with Metabolic Syndrome

Cited by 4 publications

References 59 publications

Features of metabolic disorders in centenarians

Features of metabolic disorders in centenarians

Hyperuricemia and Cardiovascular Diseases in Very Elderly Patients with Coronary Artery Disease

Egyptian consensus on treat-to-target approach of gout: evidence-based clinical practice guidelines for the management of gout

Contact Info

Product

Resources

About