Comparison of solid dispersions produced by supercritical antisolvent and spray-freezing technologies

Badens, Elisabeth; Majerik, Viktor; Horváth, Géza; Szokonya, László; Bosc, Nathalie; Teillaud, E.; Charbit, G.

doi:10.1016/j.ijpharm.2009.04.047

Cited by 52 publications

(11 citation statements)

References 36 publications

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“…These techniques have successfully been used in the production of microand nanoparticles as well as ASDs to achieve particle size control and solubility. The ability to produce narrow particle size distribution with desired morphology has been extensively used in designing drug products for inhalation (York 1999;Lobo et al 2005;Badens et al 2009;Ayad et al 2013). …”

Section: Discussionmentioning

confidence: 99%

Amorphous Solid Dispersions

Shah¹,

Sandhu²,

Choi³

et al. 2014

Advances in Delivery Science and Technology

112

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Section: Discussionmentioning

confidence: 99%

Amorphous Solid Dispersions

Shah¹,

Sandhu²,

Choi³

et al. 2014

Advances in Delivery Science and Technology

112

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“…Then, the solvent is removed by lyophilization. Badens et al [39] compared SFD with SC ant solvent method on Oxeglitazar. They investigated that SFD shown lower crystallinity and higher dissolution rate.…”

Section: Ultra Rapid Freezingmentioning

confidence: 99%

Recent Approaches of Solid Dispersion: A New Concept Toward Oral Bioavailability Sabitri Bindhani* , Snehamayee Mohapatra

Bindhani

Mohapatra

2018

Asian J Pharm Clin Res

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Solid dispersion (SD) has been a major advanced technology in overcoming dissolution and bioavailability problem of poorly soluble compounds. Formulation of SD in water-soluble carrier has becoming more researched over the past four decades for solubility and relative bioavailability enhancement. By reduction of the size of the drug particle to the minimum level which will enhance drug wettability and ultimately bioavailability will be definitely improved. This review article elaborates recent advanced technology and characterization of SDs and also discusses the problems and their solution for the development of better formulations.

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“…Gas antisolvent crystallization supercritical fluid technique has been employed to prepare solid dispersion [62,66,67,97,98]. Principally, the drug, carrier and/or additive are dissolved or dispersed in a mixture of organic solvent such as ethanol and methylene chloride [7].…”

Section: Supercritical Fluid Processingmentioning

confidence: 99%

Oral Fast-Release Solid Dispersion-Paradigm Shift to Nanoparticles

Wong

2011

DDF

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Design of oral fast-release solid dispersion of poorly water-soluble drugs has been a great challenge over past decades on issues of drug recrystallization, drug polymorphism, formulation limited to low drug-to-carrier ratio and drug particle aggregation in matrix. The complexity in solid dispersion design is envisaged to be resolvable by the use of nanoparticulate system as solid dosage form. This manuscript reviews several patented processing approaches of nanoparticulate solid dispersion that have been reported recently. Through drug nanoencapsulation, a higher content of drug may be delivered with less aggregation via placing the same drug mass in a greater number of tinier carriers. Nanoencapsulation, by its own process of formation, brings about submicron particles. Keeping drug in these nanoparticles, a remarkable rise in specific surface area of drug is realized for dissolution. The augmentation of drug dissolution can be sufficiently high to the extent that the influences of polymorphism and crystallization phenomenon on drug dissolution in a solid dispersion may be negligible.

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Comparison of solid dispersions produced by supercritical antisolvent and spray-freezing technologies

Cited by 52 publications

References 36 publications

Amorphous Solid Dispersions

Amorphous Solid Dispersions

Recent Approaches of Solid Dispersion: A New Concept Toward Oral Bioavailability Sabitri Bindhani* , Snehamayee Mohapatra

Oral Fast-Release Solid Dispersion-Paradigm Shift to Nanoparticles

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