Comparison of some salivary characteristics between children with and without early childhood caries

Bagherian, Ali; Asadikaram, Gholamreza

doi:10.4103/0970-9290.107380

Cited by 41 publications

(52 citation statements)

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“…20 Furthermore, various studies have shown that altered salivary pH, BC and ALP levels are associated with the formation or development of dental caries, gingivitis, periodontitis, human immunodeficiency virus (HIV) infection, diabetes, orthodontic tooth movements, cancer, abdominal inflammatory diseases and the early onset of menopause. 3,4,12,13,[21][22][23][24][25][26][27][28][29] In the current study, salivary pH was lower among smokers in comparison to non-smokers; although the mean values found seem to reflect a minimal difference between the two groups (7.42 versus 7.52, respectively), even very small alterations in pH can influence salivary enzyme activity. 6 Additionally, BC was significant lower among smokers in the current study.…”

Section: Discussionmentioning

confidence: 98%

“…12 Bagherian et al reported lower pH and BC values among children without caries. 13 In contrast, another study indicated lower resting salivary pH values among individuals with dental caries.…”

mentioning

confidence: 92%

“…After this, the pH of each saliva sample was determined using a pH meter (Hanna Instruments Inc., Ann Arbor, Michigan, USA). 13 The salivary BC was then evaluated by the addition of 1 mL of 0.1 N of hydrochloric acid to 1 mL of saliva. The BC was calculated according to changes in pH and ranked via the Ericsson method as high (pH >5.5), moderate (pH 4.5-5.5) or low (pH <4.5).…”

Section: Methodsmentioning

confidence: 99%

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Comparison of Salivary pH, Buffering Capacity and Alkaline Phosphatase in Smokers and Healthy Non-Smokers: Retrospective cohort study

Ahmadi‐Motamayel¹,

Falsafi²,

Goodarzi³

et al. 2016

SQUMJ

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abstract:Objectives: Saliva contains alkaline phosphatase (ALP)-a key intracellular enzyme related to destructive processes and cellular damage-and has buffering capacity (BC) against acids due to the presence of bicarbonate and phosphate ions. Smoking may have deleterious effects on the oral environment due to pH changes which can affect ALP activity. This study aimed to evaluate the salivary pH, BC and ALP activity of male smokers and healthy non-smokers. Methods: This retrospective cohort study took place between August 2012 and December 2013. A total of 251 healthy male non-smokers and 259 male smokers from Hamadan, Iran, were selected. Unstimulated whole saliva was collected from each participant and pH and BC were determined using a pH meter. Salivary enzymes were measured by spectrophotometric assay. Results: Mean salivary pH (7.42 ± 0.48 and 7.52 ± 0.43, respectively; P = 0.018) and BC (3.41 ± 0.54 and 4.17 ± 0.71; P = 0.001) was significantly lower in smokers compared to non-smokers. Mean ALP levels were 49.58 ± 23.33 IU/L among smokers and 55.11 ± 27.85 IU/L among non-smokers (P = 0.015). Conclusion: Significantly lower pH, BC and ALP levels were observed among smokers in comparison to a healthy control group. These salivary alterations could potentially be utilised as biochemical markers for the evaluation of oral tissue function and side-effects among smokers. Further longitudinal studies are recommended to evaluate the effects of smoking on salivary components.

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Section: Discussionmentioning

confidence: 98%

mentioning

confidence: 92%

Section: Methodsmentioning

confidence: 99%

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Comparison of Salivary pH, Buffering Capacity and Alkaline Phosphatase in Smokers and Healthy Non-Smokers: Retrospective cohort study

Ahmadi‐Motamayel¹,

Falsafi²,

Goodarzi³

et al. 2016

SQUMJ

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“…Different results reported that there was no difference in total sIgA concentrations in caries-free children with children having caries experience≥ 5 [27]. Bagherian & Asadikaram [34] reported the opposite results that the highest total sIgA concentration was owned by ECC children (196.14 ± 100.07 mg/dl) than in caries-free children (148.45 ± 81.26 mg/dl; p=0.015).…”

Section: Literature Review a Secretory Immunoglobulin A And The mentioning

confidence: 95%

“…From several studies, it can be concluded that there was a relationship between sIgA concentration and caries incidence [21,33,34], therefore sIgA concentrations could be developed as an ECC risk assessment biomarker.…”

Section: Literature Review a Secretory Immunoglobulin A And The mentioning

confidence: 99%

sIgA and Lisozim as Biomarker of Early Childhood Caries Risk

Octiara¹,

Sutadi²,

Siregar³

et al. 2018

Proceedings of the International Dental Conference of Sumatera Utara 2017 (IDCSU 2017)

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Abstract-Caries in children under 6 years old (Early Childhood Caries) is still a major oral health problems in many countries. The high prevalence of ECC should be prevented immediately based on the cause of caries. Saliva is one of the factors that play role in dental caries process, also play a role as caries prevention. This article describes the relationship between sIgA and salivary lysozyme to the incidence of ECC and the development of that protein as one of the caries biomarkers. Several studies reported that sIgA in caries-free children had higher concentrations than in ECC children. Lysozyme concentrations in unstimulated saliva are also significantly higher in the caries-free group compared with the ECC group. Determination of lysozyme and sIgA level in saliva may be helpful in diagnosing caries diseases and infections. It is concluded that the development of sIgA and salivary lysozyme can be used as one of the biomarkers for dental caries detection, risk assessment, diagnosis, prognosis and disease monitoring, and evaluation in ECC.

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Mass spectrometry‐based proteomic approaches for salivary protein biomarkers discovery and dental caries diagnosis: A critical review

Ahmad

Hussain

Siqueira

2022

Mass Spectrometry Reviews

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Dental caries is a multifactorial chronic disease resulting from the intricate interplay among acid‐generating bacteria, fermentable carbohydrates, and several host factors such as saliva. Saliva comprises several proteins which could be utilized as biomarkers for caries prevention, diagnosis, and prognosis. Mass spectrometry‐based salivary proteomics approaches, owing to their sensitivity, provide the opportunity to investigate and unveil crucial cariogenic pathogen activity and host indicators and may demonstrate clinically relevant biomarkers to improve caries diagnosis and management. The present review outlines the published literature of human clinical proteomics investigations on caries and extensively elucidates frequently reported salivary proteins as biomarkers. This review also discusses important aspects while designing an experimental proteomics workflow. The protein–protein interactions and the clinical relevance of salivary proteins as biomarkers for caries, together with uninvestigated domains of the discipline are also discussed critically.

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Comparison of some salivary characteristics between children with and without early childhood caries

Abstract: The higher mean resting salivary pH and better buffering capacity found in children without ECC are probably the contributing factors that protect against caries development; but further studies are needed to understand the effects of saliva and its characteristics and components on ECC.

Cited by 41 publications

References 1 publication

Comparison of Salivary pH, Buffering Capacity and Alkaline Phosphatase in Smokers and Healthy Non-Smokers: Retrospective cohort study

Comparison of Salivary pH, Buffering Capacity and Alkaline Phosphatase in Smokers and Healthy Non-Smokers: Retrospective cohort study

sIgA and Lisozim as Biomarker of Early Childhood Caries Risk

Mass spectrometry‐based proteomic approaches for salivary protein biomarkers discovery and dental caries diagnosis: A critical review

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