sIgA and Lisozim as Biomarker of Early Childhood  Caries Risk

Octiara, Essie; Sutadi, Heriandi; Siregar, Yahwardiah; Primasari, Ameta

doi:10.2991/idcsu-17.2018.26

Cited by 3 publications

(2 citation statements)

References 37 publications

(57 reference statements)

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“…Protein concentration in each person's saliva varies with age, as the amount will increase with age. Alterations in salivary secretion with age are associated with a higher risk of carious lesion and caries incidence (Octiara et al, 2018). In general, this result can be seen in Table 2.…”

Section: Relationship Between Lysozyme Activity With Ecc and Caries C...mentioning

confidence: 77%

Lysozyme quantity and quality in relation with early childhood caries: A longitudinal study

Octiara¹,

Sutadi²,

Siregar³

et al. 2022

J Pharm Pharmacogn Res

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Context: Several studies have reported the relationship between lysozyme quantity (concentration) and quality (activity) with early childhood caries (ECC), but the results remain controversial. These are controversial, probably due to the cross-sectional design used in previous studies. Aims: To analyze the relation between lysozyme quantity and quality with ECC in two years old children. Methods: An observational analytic with a cohort study for nine months, with a total sample of 68 caries-free children aged 9-24 months old, selected by purposive sampling from Integrated Healthcare Center in Medan, Indonesia. The subject must have at least two primary upper incisors that have erupted. Lysozyme examination was carried out three times, at the beginning of the month, the third and the ninth month. ECC examination was assessed using the American Association of Pediatric Dentistry criteria. Lysozyme concentration was measured using a competitive ELISA method with human lysozyme C (Fine Test). Then lysozyme reading was done at an absorbance of 450 nm using a microplate reader. Lysozyme activity was assessed using the Lysozyme Detection Kit (Sigma-Aldrich and ready by spectrophotometer. Data analysis was processed with an unpaired t-test, Mann-Whitney test, and longitudinal analysis using a generalized estimating equation (linear) test with a significant value, p<0.05. Results: This showed that there was not any relationship found between lysozyme concentration and ECC (p>0.05). However, there was a relationship between lysozyme activity and ECC (p=o.oo8). Conclusions: ECC children had higher lysozyme activity when compared to caries-free children.

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Section: Relationship Between Lysozyme Activity With Ecc and Caries C...mentioning

confidence: 77%

Lysozyme quantity and quality in relation with early childhood caries: A longitudinal study

Octiara¹,

Sutadi²,

Siregar³

et al. 2022

J Pharm Pharmacogn Res

Self Cite

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“…Salivary proteins that can serve as biomarkers for dental caries are classified by their function as immune or nonimmune factors. The primary immune factor in saliva is sIgA, while nonimmune factors include lysozyme, lactoferrin, salivary peroxidase, and others [12,13]. sIgA is the predominant immunological protein in saliva, constituting 60% of the total proteins, and is crucial for the initial defense of immune system against microbial invasion [14].…”

Section: Introductionmentioning

confidence: 99%

The Influence of Black Tea on Secretory IgA from Saliva in Caries and Caries-Free Subjects

Fitri,

Yendriwati,

Astari

et al. 2024

JBBBE

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The crucial role of saliva in the prevention of dental caries is associated with the regulation of its flow rate as well as salivary protein. Black tea, derived from the plant Camellia sinensis, contains catechins and has been shown to have a beneficial effect on saliva in preventing tooth decay. Nevertheless, research on the oral health benefits of black tea is still limited. This study aimed to investigate the effects of black tea (Camellia sinensis) on salivary pH (potential hydrogen), salivary flow rate, lysozyme, and sIgA levels in caries and caries-free patients. The study used a quasi-experimental design with a pre-test and a post-test. Twenty six subjects (male or female) were selected and divided into two groups (caries and caries free), thirteen subjects for each. Saliva samples were obtained before and thirty minutes after tea consumption. The flow rate of saliva was measured by dividing the weight of saliva collected by the time. At the same time, secretory immunoglobulin A (sIgA) levels were analyzed by enzyme-linked immunosorbent assay (ELISA). The t-dependent and t-independent tests and Mann-Whitney tests were selected to evaluate the effect of drinking black tea on salivary flow rate and sIgA value. The results showed that black tea significantly increased salivary flow rate but did not significantly affect the concentration of sIgA. No statistically significant differences in salivary flow rate and sIgA were observed between patients with and without caries after tea consumption. Although the concentration of sIgA did not demonstrate a significant change, however, the salivary flow rate was significantly enhanced. Therefore, drinking black tea did not negatively affect the saliva in the oral cavity, suggesting it can be a good option for daily consumption due to its protective role against dental caries.

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Innate Immunity Signatures of Early Childhood Caries (ECC) and Severe Early Childhood Caries

Astuti

Sukrama

Mahendra

2019

Biomed. Pharmacol. J.

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Caries that affects children under the age of 6 is known as early childhood caries (ECC). According to the American Academy of Pediatric Dentistry (AAPD), ECC is defined as the presence of one or more teeth with caries (cavities or no cavities), missing teeth due to caries or the presence of restoration deciduous teeth in children under 71 months. If it occurred on the smooth surface of the tooth in children under 3 years of age, the disease is classified as severe early childhood caries (S-ECC). Streptococcus mutans plays important role in the etiology of caries of preschool children, which is a contagious pathological entity. The pathogen is an acidogenic and aciduric bacteria. The occurrence of caries is a complex process of interaction between host factors (teeth), microorganisms, substrates (carbohydrates) and the environment, including saliva. This mini review aims to summarize current findings on several markers of innate immune system related to ECC and S-ECC namely lysozyme, salivary lactoferrin, IL-8, CD36 of salivary neutrophils, and sCD14

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sIgA and Lisozim as Biomarker of Early Childhood Caries Risk

Cited by 3 publications

References 37 publications

Lysozyme quantity and quality in relation with early childhood caries: A longitudinal study

Lysozyme quantity and quality in relation with early childhood caries: A longitudinal study

The Influence of Black Tea on Secretory IgA from Saliva in Caries and Caries-Free Subjects

Innate Immunity Signatures of Early Childhood Caries (ECC) and Severe Early Childhood Caries

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