Comparison of Tanapox virus and Yaba-like viruses causing epidemic disease in monkeys

Downie, A. W.; Espana, Carlos

doi:10.1017/s0022172400022051

Cited by 44 publications

(25 citation statements)

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“…73,2009 POXVIRUS PROTEOMICS AND VIRUS-HOST PROTEIN INTERACTION 741 direct binding partner that links M-T5 to the host SCF complex. Yaba monkey tumor virus (YMTV) is a member of the genus Yatapoxvirus and can cause distinct epidermal histiocytomas (cutaneous benign skin tumors) of the head and limbs in nonhuman primates (49). YMTV 12L is an ortholog of VACV K3L, which has been studied extensively not only for its interaction with PKR (152) but also for the significance of its biological functions in evolution (52).…”

Section: Virus-host-interacting Partnersmentioning

confidence: 99%

Poxvirus Proteomics and Virus-Host Protein Interactions

Vliet

Mohamed

Zhang

et al. 2009

Microbiol Mol Biol Rev

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SUMMARY Studies of the functional proteins encoded by the poxvirus genome provide information about the composition of the virus as well as individual virus-virus protein and virus-host protein interactions, which provides insight into viral pathogenesis and drug discovery. Widely used proteomic techniques to identify and characterize specific protein-protein interactions include yeast two-hybrid studies and coimmunoprecipitations. Recently, various mass spectrometry techniques have been employed to identify viral protein components of larger complexes. These methods, combined with structural studies, can provide new information about the putative functions of viral proteins as well as insights into virus-host interaction dynamics. For viral proteins of unknown function, identification of either viral or host binding partners provides clues about their putative function. In this review, we discuss poxvirus proteomics, including the use of proteomic methodologies to identify viral components and virus-host protein interactions. High-throughput global protein expression studies using protein chip technology as well as new methods for validating putative protein-protein interactions are also discussed.

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Section: Virus-host-interacting Partnersmentioning

confidence: 99%

Poxvirus Proteomics and Virus-Host Protein Interactions

Vliet

Mohamed

Zhang

et al. 2009

Microbiol Mol Biol Rev

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“…This virus produces a very distinct disease in primates that is characterized by epidermal histiocytomas of the head and limbs (7,12). Although the exact host reservoir of YMTV is not established, it is presumed that the immunomodulatory proteins expressed by this virus can at least partially cope with the primate/human immune system.…”

mentioning

confidence: 99%

Yaba Monkey Tumor Virus Encodes a Functional Inhibitor of Interleukin-18

Nazarian

Rahman

Werden

et al. 2008

J Virol

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Interleukin-18 (IL-18) is a critical proinflammatory cytokine whose extracellular bioactivity is regulated by a cellular IL-18 binding protein (IL-18BP). Many poxviruses have acquired variants of this IL-18BP gene, some of which have been shown to act as viral virulence factors. Yaba monkey tumor virus (YMTV) encodes a related family member, 14L, which is similar to the orthopoxvirus IL-18BPs. YMTV 14L was expressed from a baculovirus system and tested for its ability to bind and inhibit IL-18. We found that YMTV 14L bound both human IL-18 (hIL-18) and murine IL-18 with high affinity, at 4.1 nM and 6.5 nM, respectively. YMTV 14L was able to fully sequester hIL-18 but could only partially inhibit the biological activity of hIL-18 as measured by gamma interferon secretion from KG-1 cells. Additionally, 17 hIL-18 point mutants were tested by surface plasmon resonance for their ability to bind to YMTV 14L. Two clusters of hIL-18 surface residues were found to be important for the hIL-18-YMTV 14L interaction, in contrast to results for the Variola virus IL-18BP, which has been shown to primarily interact with a single cluster of three amino acids. The altered binding specificity of YMTV 14L most likely represents an adaptation resulting in increased fitness of the virus and affirms the plasticity of poxviral inhibitor domains that target cytokines like IL-18.

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“…A previously sequenced poxvirus, Yaba-like disease virus (YLDV) (Lee et al, 2001), is a TPV from an infected non-human primate Espana et al, 1971;Esposito and Fenner, 2001;McNulty et al, 1968). TPV and YLDV are suspected to be transmitted by arthropod vectors and both produce a similar rash illness, fever with prodromal symptoms that is followed by the development of few nodular skin lesions (Downie and Espana, 1972;Damon, 2007;Knight et al, 1989). In contrast, YMTV produces a very distinct disease, primarily in non-human primates, which is characterized by epidermal histiocytomas of the head and limbs (Downie and Espana, 1972;Knight et al, 1989).…”

mentioning

confidence: 99%

“…TPV and YLDV are suspected to be transmitted by arthropod vectors and both produce a similar rash illness, fever with prodromal symptoms that is followed by the development of few nodular skin lesions (Downie and Espana, 1972;Damon, 2007;Knight et al, 1989). In contrast, YMTV produces a very distinct disease, primarily in non-human primates, which is characterized by epidermal histiocytomas of the head and limbs (Downie and Espana, 1972;Knight et al, 1989). The observed biological differences between YMTV and YLDV are likely explained by the 82% nucleotide identity and an approximately 10 kbp deletion from YMTV compared to YLDV Downie and Espana, 1972;Espana et al, 1971;Knight et al, 1989;Lee et al, 2001).…”

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confidence: 99%

Comparative genetic analysis of genomic DNA sequences of two human isolates of Tanapox virus

et al. 2007

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Members of the genus Yatapoxvirus, which include Tanapox virus (TPV) and Yaba monkey tumor virus, infect primates including humans. Two strains of TPV isolated 50 years apart from patients infected from the equatorial region of Africa have been sequenced. The original isolate from a human case in the Tana River Valley, Kenya, in 1957 (TPV-Kenya) and an isolate from an infected traveler in the Republic of Congo in 2004 (TPV-RoC). Although isolated 50 years apart the genomes were highly conserved. The genomes differed at only 35 of 144,565 nucleotide positions (99.98% identical). We predict that TPV-RoC encodes 155 ORFs, however a single transversion (at nucleotide 10241) in TPV-Kenya resulted in the coding capacity for two predicted ORFs (11.1L and 11.2L) in comparison to a single ORF (11L) in TPV-RoC. The genomes of TPV are A + T rich (73%) and 96% of the sequence encodes predicted ORFs. Comparative genomic analysis identified several features shared with other chordopoxviruses. A conserved sequence within the terminal inverted repeat region that is also present in the other members of the Yatapoxviruses as well as members of the Capripoxviruses, Swinepox virus and an unclassified Deerpox virus suggests the existence of a conserved near-terminal sequence secondary structure. Two previously unidentified gene families were annotated that are represented by ORF TPV28L, which matched homologues in certain other chordopoxviruses, and TPV42.5L, which is highly conserved among currently reported chordopoxvirus sequences.

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Comparison of Tanapox virus and Yaba-like viruses causing epidemic disease in monkeys

Cited by 44 publications

References 10 publications

Poxvirus Proteomics and Virus-Host Protein Interactions

Poxvirus Proteomics and Virus-Host Protein Interactions

Yaba Monkey Tumor Virus Encodes a Functional Inhibitor of Interleukin-18

Comparative genetic analysis of genomic DNA sequences of two human isolates of Tanapox virus

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