Comparison of the bioavailability of nano- and micro-sized copper oxide particles in copper-deficient mice

The effect of copper nanoparticles and copper (II) salt on redox reactions and epigenetic changes in a rat model

“…Prohaska and Lukasewycz () found that a copper deficiency in the diet of mice led to hypoceruloplasminaemia. Seol et al () also found a decrease in serum Cp activity in mice fed a Cu‐poor diet (0.93 mg Cu/kg) for 7 weeks. In the same study, in which Seol et al () administered the recommended level of CuO in the form of NP (50 nm) or MP (≤10 µm) to mice per os, they found that the dosage of Cu plays a greater role in maintaining normal Cp activity in the blood than the form of Cu.…”

“…Seol et al () also found a decrease in serum Cp activity in mice fed a Cu‐poor diet (0.93 mg Cu/kg) for 7 weeks. In the same study, in which Seol et al () administered the recommended level of CuO in the form of NP (50 nm) or MP (≤10 µm) to mice per os, they found that the dosage of Cu plays a greater role in maintaining normal Cp activity in the blood than the form of Cu. Our study showed that both the dose and the form affected Cp activity, as CuNP increased plasma Cp activity in the rats more than CuCO 3 .…”

Comparison of the effect of dietary copper nanoparticles and one copper (II) salt on the copper biodistribution and gastrointestinal and hepatic morphology and function in a rat model

“…Hence it can be assumed that copper metabolism was not impaired in the rats from any of the experimental treatments. Seol et al [ 40 ] observed no effect of 11-week dietary supplementation with copper carbonate at doses of 6.36 mg Cu/kg or 0.93 mg Cu/kg in the diet of rats. According to other authors [ 34 , 43 ], Cu added (in the form of sulphate or carbonate) to the diet of rats improves their growth performance and reduces feed intake.…”

The effect of copper level in the diet on the distribution, and biological and immunological responses in a rat model

“…Numerous studies indicate that the liver, kidneys and brain are the organs in which the most Cu is accumulated (Ozkul et al, 2011;Arnal et al, 2014;Kumar et al, 2015;Seol et al, 2015). Seol et al (2015) reported a decrease in Cu content in the liver of mice fed a Cu-deficient diet (0.93 mg Cu/kg) for 11 weeks in relation to controls receiving the recommended dose of Cu (6.36 mg Cu/kg) in the diet. In a study by Lee et al (2016) it was also shown lower Cu content in the liver, kidneys, spleen, brain, lungs and heart of rats fed a Cu-deficient diet for 28 days as compared to animals receiving 100, 200 or 400 mg Cu/kg by gavage.…”

“…In recent years there were few studies showing that the lack of supplementation of Cu in the diet is not as harmful as previously assumed. The organism can adapt perfectly to these seemingly unfavourable eating conditions (Seol et al, 2015;Shukla et al, 2015). Therefore, the aim of our study was to assess the effect of a Cu deficiency in the diet on the absorption and biodistribution of this element and on haematological, immune and biochemical parameters in rats.…”