Comparison of the Biological Properties of ProRoot MTA, OrthoMTA, and Endocem MTA Cements

Kim, Miri; Yang, Wenjun; Kim, Hee-Sun; Ko, Hyunjung

doi:10.1016/j.joen.2014.04.013

Cited by 52 publications

(47 citation statements)

References 28 publications

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“…Therefore, extended Ca release from calcium silicate-based cements can influence the osteogenic potential of bone marrow stem cells and osteoblast progenitors [39,40]. In the present study, all tested calcium silicate-based cements were associated with an alkaline pH ( Table 2), consistent with the findings of previous studies [23,41,42]. The high alkalinity of the materials contributes to their osteogenic potential as a suitable condition for matrix formation and antimicrobial ability is created.…”

Section: Discussionsupporting

confidence: 91%

Cytotoxicity and Mineralization Potential of Four Calcium Silicate-Based Cements on Human Gingiva-Derived Stem Cells

et al. 2020

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The aim of this study was to evaluate the cytotoxicity and mineralization potential of four calcium silicate-based cements on human gingiva-derived stem cells (GDSCs). The materials evaluated in the present study were ProRoot MTA (Dentsply Tulsa Dental Specialties), Biodentine (Septodont), Endocem Zr (Maruchi), and RetroMTA (BioMTA). Experimental disks of 6 mm in diameter and 3 mm in height were produced and placed in a 100% humidified atmosphere for 48 h to set. We evaluated the cytotoxic effects of the cements using methyl-thiazoldiphenyl-tetrazolium (MTT) and live/dead staining assays. We used a scratch wound healing assay to evaluate cell migratory ability. Mineralization potential was determined with an Alizarin red S (ARS) staining assay. In the MTT assay, no significant differences were found among the ProRoot MTA, Biodentine, and control groups during the test period (p > 0.05). The Endocem Zr and RetroMTA groups showed relatively lower cell viability than the control group at day 7 (p < 0.05). In the wound healing assay, no significant differences were found among the ProRoot MTA, Biodentine, Endocem Zr, and control groups during the test period (p > 0.05). The RetroMTA group had slower cell migration compared to the control group at days 3 and 4 (p < 0.05). In the ARS assay, the ProRoot MTA, Biodentine, and RetroMTA groups exhibited a significant increase in the formation of mineralized nodules compared to the Endocem Zr and control groups on day 21 (p < 0.05). In conclusion, the four calcium silicate-based cements evaluated in the present study exhibited good biological properties on GDSCs. ProRoot MTA, Biodentine, and RetroMTA showed higher mineralization potential than the Endocem Zr and control groups.

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Section: Discussionsupporting

confidence: 91%

Cytotoxicity and Mineralization Potential of Four Calcium Silicate-Based Cements on Human Gingiva-Derived Stem Cells

et al. 2020

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“…All the three MTA materials tested inhibited the growth of caries-associated bacteria, with MTA-Angelus having the greatest effect, followed by ProRoot MTA, and finally Endocem MTA. Despite the fact that ProRoot MTA was also very effective in inhibiting the growth of caries-associated bacteria, either MTA-Angelus or Endocem MTA seem to be the materials of choice for pulp capping in one-visit deep caries treatment, because the shorter setting time of MTA-Angelus (14 (Santos, Araujo, Yukimitu, Barbosa, & Moraes, 2008)-15 min (Angelus, 2015)) and Endocem MTA (4 (Choi et al, 2013)-15 min (Kim, Yang, Kim, & Ko, 2014)) compared to that of ProRoot MTA (140 (Islam, Chng, & Yap, 2006)-318 min (Kim et al, 2014)) enables the placement of permanent restoration in a single visit. This would not only save chair time but also help minimize possible contamination of the cavity, which may occur during the temporization period in a conventional two-visit treatment wherein a permanent restoration is placed over the set MTA in the next visit.…”

Section: Discussionmentioning

confidence: 99%

An in vitro evaluation of the antibacterial properties of three mineral trioxide aggregate (MTA) against five oral bacteria

Kim

Lee

et al. 2015

Archives of Oral Biology

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“…Endocem is also an improved calcium silicate-based cements, composed of calcium oxide, aluminum oxide, silicate oxide, magnesium oxide, and bismuth trioxide (28). It sets in approximately 4 min, because it contains small-particle pozzolan cement.…”

Section: Endocemmentioning

confidence: 99%

Long-term clinical and radiographic evaluation of the effectiveness of direct pulp-capping materials

2019

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The aim of this review was to assess the effectiveness of different direct pulp-capping (DPC) materials for human pulp-exposed teeth. An electronic search was performed on 20 February 2018. Long-term clinical and radiographic evaluations of the effectiveness of different DPC materials for use on human pulp-exposed teeth were included. Risk-ofbias assessment and data extraction were performed. From the 496 identified articles, 15 met the eligibility criteria. Among the studies included in those articles, a total of 1,322 teeth were treated with 12 types of DPC materials, and 1,136 teeth were evaluated at a final follow-up examination. For mineral trioxide aggregate (MTA) and calcium hydroxide (CH), the number of included studies, the number of treated teeth, and the mean follow-up period of studies were almost equal, and the success rates of MTA was superior to CH. Therefore, MTA is likely to be a more effective and predictable material for DPC compared to CH. However, the results were based on the included studies, which were all judged to have a high risk of bias. Therefore, more long-term clinical and radiographic studies designed with lower risk of bias are needed. Moreover, the other 10 materials were only investigated by a small number of studies; therefore, further studies are required.

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Comparison of the Biological Properties of ProRoot MTA, OrthoMTA, and Endocem MTA Cements

Cited by 52 publications

References 28 publications

Cytotoxicity and Mineralization Potential of Four Calcium Silicate-Based Cements on Human Gingiva-Derived Stem Cells

Cytotoxicity and Mineralization Potential of Four Calcium Silicate-Based Cements on Human Gingiva-Derived Stem Cells

An in vitro evaluation of the antibacterial properties of three mineral trioxide aggregate (MTA) against five oral bacteria

Long-term clinical and radiographic evaluation of the effectiveness of direct pulp-capping materials

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