Comparison of the cellular cytotoxic activities of colostral lymphocytes and maternal peripheral blood lymphocytes

Nair, Madhavan; Schwartz, Stanley A.; Slade, Herbert B.; Johnson, Mary Z.; Quebbeman, James F.; Beer, Alan E.

doi:10.1016/0165-0378(85)90051-8

Cited by 9 publications

(5 citation statements)

References 66 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These reports are consistent with reports that neutrophils recovered from human mammary secretions showed a reduction in functionality, e.g. motility, phagocytosis, respiratory burst, and PMN (polymorphonuclear) cell-mediated cytotoxicity, compared with serum-derived cells (Kohl and Loo, 1980; Nair et al , 1985; Schollenberger et al , 1986; Özkaragöz et al , 1988).…”

Section: Immunological Functions Of Mammary Secretionssupporting

confidence: 90%

Historical and contemporary aspects of maternal immunity in swine

Poonsuk

Zimmerman

2017

Anim. Health. Res. Rev.

View full text Add to dashboard Cite

Maternal immunity plays a pivotal role in swine health and production because piglets are born agammaglobulinemic and with limited cell-mediated immunity, i.e. few peripheral lymphoid cells, immature lymphoid tissues, and no effector and memory T-lymphocytes. Swine do not become fully immunologically competent until about 4 weeks of age, which means that their compromised ability to respond to infectious agents during the first month of life must be supplemented by maternal immune components: (1) circulating antibodies derived from colostrum; (2) mucosal antibodies from colostrum and milk; and (3) immune cells provided in mammary secretions. Because maternal immunity is highly effective at protecting piglets against specific pathogens, strengthening sow herd immunity against certain diseases through exposure or vaccination is a useful management tool for ameliorating clinical effects in piglets and delaying infection until the piglets' immune system is better prepared to respond. In this review, we discuss the anatomy and physiology of lactation, the immune functions of components provided to neonatal swine in mammary secretion, the importance of maternal immunity in the prevention and control of significant pathogens.

show abstract

Section: Immunological Functions Of Mammary Secretionssupporting

confidence: 90%

Historical and contemporary aspects of maternal immunity in swine

Poonsuk

Zimmerman

2017

Anim. Health. Res. Rev.

View full text Add to dashboard Cite

show abstract

“…Cumulatively, these studies suggested that phagocytic cells in swine mammary secretion are capable of phagocytosis, but may lack some intracellular functions. This reports are consistent with reports that neutrophils recovered from human mammary secretions showed a reduction in functionality, e.g., motility, phagocytosis, respiratory burst, and polymorphonuclear (PMN)-mediated cytotoxicity, compared to serum-derived cells Nair et al, 1985;Ozkaragoz et al, 1988;Schollenberger et al, 1986).…”

Section: Phagocytic Cellssupporting

confidence: 90%

An investigation of passive antibody and its effects on porcine epidemic diarrhea virus infection

Poonsuk¹

View full text Add to dashboard Cite

Maternal immunity plays a pivotal role in swine health and production because piglets are born agammaglobulinemic and with limited cell-mediated immunity, i.e., few peripheral lymphoid cells, immature lymphoid tissues, and no effector and memory T-lymphocytes. Swine do not become fully immunologically competent until about four weeks of age, which means that their compromised ability to respond to infectious agents during the first month of life must be supplemented by maternal immune components: 1) circulating antibodies derived from colostrum; 2) mucosal antibodies from colostrum and milk; and 3) immune cells provided in mammary secretions. Since maternal immunity is highly effective at protecting piglets against specific pathogens, strengthening sow herd immunity against certain diseases through exposure or vaccination is a useful management tool for ameliorating clinical effects in piglets and/or delaying infection until the piglets' immune system is better prepared to respond. In this review we discuss the anatomy and physiology of lactation, the immune functions of components provided to neonatal swine in mammary secretion, the importance of maternal immunity in the prevention and control of significant pathogens.

show abstract

“…Separation of lymphocytes from other milk cells is a difficult task, and the use of unseparated cells risks the release from accessory cells of preformed IgA, and possibly suppressive substances (22), into the culture system. Early work from our lab suggests that BM B-cells may be regulated in a unique fashion by the products they elaborate (23).…”

Section: Resultsmentioning

confidence: 99%

Antigen-Driven Immunoglobulin Production by Human Colostral Lymphocytes

Slade

Schwartz

1989

Pediatr Res

View full text Add to dashboard Cite

ABSTRACT. It has long been recognized that human milk contains substantial quantities of secretory IgA which is elaborated by plasma cells located proximal to the ductal epithelium. The presence of lymphocytes, granulocytes and macrophages in the milk itself raises the question of whether these "shed" milk cells might potentially serve a function with regard to protecting the suckling neonate from infection. The functionality of milk B-lymphocytes has remained particularly controversial. In this report, we describe the use of a novel technique of milk cell separation prior to cell culture and demonstrate the ability of colostral B-lymphocytes to elaborated immunoglobulin in response to antigenic stimulation using vaccine strain polio virus. (Pediatv Res 25:295-299, 1989Abbreviations BM, breast milk PBMC, peripheral blood mononuclear cells LeuOME, leucine 0-methyl ester PWM, pokeweed mitogen Although it is well established that human milk secretory IgA is produced locally in the lactating mammary gland, the ability of "shed" colostral B-lymphocytes to produce immunoglobulin in vitro has remained a topic of debate (I). Various groups of 'investigators have reported evidence that these cells will produce IgA under appropriate conditions (2-5), but others have failed to demonstrate functionality using similar methodologies (6-8). It might be hypothesized that these B-cells would not be fully functional on the basis of studies showing that colostral T-cells, natural killer cells, macrophages, and polymorphonuclear cells are generally hyporesponsive when studied in vitro. Reversing the argument, if the majority of colostral cell types exhibit some degree of functionality, then it is hypothetically probable that colostral B-cells retain activity. One difficulty encountered in the study of these cells is the abundance of IgA found within milk phagocytic cells, which easily obscures the relatively smaller amount of IgA that might be synthesized de novo. We have, therefore, used a novel method for the preparation of reasonably pure colostral lymphocytes and have tested the hypothesis of functionality by determining the ability of colostral B-cells to elaborate Ig in vitro in response to inactivated polio virus.

show abstract

Comparison of the cellular cytotoxic activities of colostral lymphocytes and maternal peripheral blood lymphocytes

Cited by 9 publications

References 66 publications

Historical and contemporary aspects of maternal immunity in swine

Historical and contemporary aspects of maternal immunity in swine

An investigation of passive antibody and its effects on porcine epidemic diarrhea virus infection

Antigen-Driven Immunoglobulin Production by Human Colostral Lymphocytes

Contact Info

Product

Resources

About