Comparison of the chemical and biochemical composition of thirteen muscles of the rat after dietary protein restriction

Spence, C. A.; Hansen-Smith, Fay M.

doi:10.1079/bjn19780080

Cited by 28 publications

(12 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Gastrocnemius muscle and BAT were excised, immediately frozen in liquid nitrogen and stored at −80°C until analysis. The gastrocnemius muscle was selected as being representative of the whole skeletal musculature for nutritional studies [27]. All experimental procedures were performed according to institutional guidelines for animal care and use at the University of Navarra.…”

Section: Methodsmentioning

confidence: 99%

Leptin, but not a β3-adrenergic agonist, upregulates muscle uncoupling protein-3 messenger RNA expression: short-term thermogenic interactions

Gómez-Ambrosi¹,

Frühbeck

Martínéz³

1999

CMLS, Cell. Mol. Life Sci.

View full text Add to dashboard Cite

UCP3 in both BAT and gastrocnemius muscle were Abstract. The short-term effects of leptin and a i 3 -adrenoceptor agonist on thermogenesis and expression unaffected. Leptin induced an upregulation of UCP3 mRNA in muscle, with no changes in BAT UCP1 of uncoupling proteins (UCPs) in brown adipose tissue mRNA. A statistical interaction was found between (BAT) and muscle and their possible interactions were leptin and Trecadrine in rectal temperature. The present assessed. One hour after administration of the i 3 -study provides evidence, for the first time, of the inducadrenoceptor agonist Trecadrine, a statistically significant increase in UCP1 messenger RNA (mRNA) tion of UCP3 mRNA expression in skeletal muscle by expression in BAT was observed, whereas UCP2 and leptin in nongenetically obese animals.

show abstract

Section: Methodsmentioning

confidence: 99%

Leptin, but not a β3-adrenergic agonist, upregulates muscle uncoupling protein-3 messenger RNA expression: short-term thermogenic interactions

Gómez-Ambrosi¹,

Frühbeck

Martínéz³

1999

CMLS, Cell. Mol. Life Sci.

View full text Add to dashboard Cite

show abstract

“…In adult rats, protein deficiency results in trunkal proteolysis to supply amino acid substrates (46), without an overall decrease in percent body fat (47). In contrast, limited dietary calories elicits both lipolysis and conservation of protein nitrogen.…”

Section: Discussionmentioning

confidence: 99%

Adaptation of the growth hormone and insulin-like growth factor-I axis to chronic and severe calorie or protein malnutrition.

Oster¹,

Fielder²,

Levin³

et al. 1995

J. Clin. Invest.

106

View full text Add to dashboard Cite

The hierarchy of diet components (e.g., protein, carbohydrate, vitamins, and minerals) influencing growth hormone (GH), insulin-like growth factor-I (IGF-I), and their binding proteins (BP) is not well defined. Young adult rats were fed diets for 1 mo that included low protein or 60% and 40% of carbohydrate calories. We hypothesized that levels of both hormones, their dominant BPs and liver IGF-I mRNA would fall, and that part of the mechanism for decreasing serum IGF-I would be enhanced IGFBP-3 protease activity. By day 30, caloric deprivation to 40% lowered serum GH, GHBP, IGF-I and IGFBP-3, and liver IGF-I mRNA. This was the only condition resulting in body weight loss (-15%) vs 39% gain in controls. Restriction to 60% calories had no impact on BP levels, slightly lowered IGF-I ( -12% ) in the face of a 95% inhibition of GH levels, while allowing a modest 9% body weight gain. Protein deprivation lowered serum GH, IGF-I and IGFBP-3, and liver IGF-I mRNA, while GHBP levels were normal. The reduced total IGF-I under these dietary conditions could not be explained by an increase in IGFBP-3 protease activity, or a decrease in the association of IGF-I with IGFBP-3 and the acid labile subunit. (J. Clin. Invest. 1995Invest. . 95:2258Invest. -2265

show abstract

“…Similarly, although MUAC is a relatively good indicator of total body fat in children, it is a poor indicator of fat-free tissue, mainly muscle [33], despite the assertions of the "muscle mass hypothesis" [34]. The various muscles lose different amounts of weight with malnutrition in animal studies [35] and clinically, muscle is mainly lost from the buttocks ("baggy pants") and shoulders, rather than from the arms. Whether different populations of children loose muscle disproportionately from various body muscles is unknown.…”

Section: Discussionmentioning

confidence: 99%

Weight-for-height and mid-upper-arm circumference should be used independently to diagnose acute malnutrition: policy implications

2016

View full text Add to dashboard Cite

Background: Anthropometric surveys of children are used to assess the nutritional status of a population. World Health Organization (WHO) recommends that either mid-upper-arm circumference (MUAC) or weight-for-height Z-scores (WHZ) are used to assess acute malnutrition prevalence. However, there are reports from several countries that the two criteria identify different children. In order to examine the external validity of these observations we have compared the direction and degree of discrepancy across countries. Methods: Anonymous data were collected from 1832 anthropometric surveys from 47 countries with measured children aged from 6 to 59 months and at least 75 malnourished subjects. The prevalence of total acute malnutrition and severe acute malnutrition was calculated using either absolute-MUAC or WHZ (WHO 2006 standards). For each country, the total number of children diagnosed as acutely malnourished by either criterion alone or by both criteria were summed from all the surveys conducted in that country. Results: In all countries a minority of children were diagnosed as malnourished by both criteria. Both the magnitude and direction of the discrepancy varied dramatically between countries with some having most children diagnosed as malnourished by MUAC and others where nearly all the children were diagnosed by WHZ alone. Eight additional countries with insufficient malnourished children were also analysed and they support the conclusions.

show abstract

Comparison of the chemical and biochemical composition of thirteen muscles of the rat after dietary protein restriction

Cited by 28 publications

References 36 publications

Leptin, but not a β3-adrenergic agonist, upregulates muscle uncoupling protein-3 messenger RNA expression: short-term thermogenic interactions

Leptin, but not a β3-adrenergic agonist, upregulates muscle uncoupling protein-3 messenger RNA expression: short-term thermogenic interactions

Adaptation of the growth hormone and insulin-like growth factor-I axis to chronic and severe calorie or protein malnutrition.

Weight-for-height and mid-upper-arm circumference should be used independently to diagnose acute malnutrition: policy implications

Contact Info

Product

Resources

About