Comparison of the content of tobacco alkaloids and tobacco-specific nitrosamines in ‘heat-not-burn’ tobacco products before and after aerosol generation

Jeong, Won Tae; Cho, Hyun Ki; Lee, Hyung Ryeol; Song, Ki Hoon; Lim, Heung Bin

doi:10.1080/08958378.2019.1572840

Cited by 3 publications

(2 citation statements)

References 27 publications

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“…Nicotine-related alkaloids (nornicotine, anatabine, anabasine and myosmine) have been demonstrated to be present in both the tobacco filler and aerosol produced from three different heated tobacco products, none of which were identified by their commercial names (Jeong et al, 2018). Cotinine, whilst detected in the tobacco filler of the 3R4F reference cigarette and CORESTA Monitor (CM7) test piece, was not detected in either the tobacco filler or aerosol produced from the heated tobacco products (the presence or otherwise of cotinine in the mainstream smoke of the two reference cigarettes was not determined) (Jeong et al, 2018).…”

Section: Nicotinementioning

confidence: 99%

“…Tobacco-specific nitrosamines (TSNAs) Several articles have identified the presence of four TSNAs (NNN, NAT, NAB and NNK) both in the tobacco filler (Bekki et al, 2017;Jaccard et al, 2018;Jeong et al, 2018) and in the aerosols generated from heated tobacco products [only NNN and NNK are included in the 2012 US FDA HPHC list] (Bekki et al, 2017;Jaccard et al, 2018;Jeong et al, 2018;Leigh et al, 2018a;Ishizaki and Kataoka, 2019;Li et al, 2019). When compared on the basis of the sum of the four main TSNAs investigated (NNN, NAT, NAB and NNK), levels observed in the aerosols of the IQOS heated tobacco product were significantly lower than those observed in conventional cigarette smoke (Bekki et al, 2017;Li et al, 2019).…”

Section: Nicotinementioning

confidence: 99%

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The product science of electrically heated tobacco products: a narrative review of the scientific literature

Malt

Thompson²,

Mason

et al. 2022

F1000Res

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Heated tobacco products represent a novel category of tobacco products in which a tobacco consumable is heated to a temperature that releases nicotine from the tobacco leaf but not to a temperature sufficient to cause combustion. Heated tobacco products may therefore have the potential to be a less harmful alternative for adult smokers that would otherwise continue to smoke conventional cigarettes. Given the rapid development of this product category, the aim of this review was to examine the available peer-reviewed scientific evidence related to heated tobacco products and highlight any research gaps. In recent years, manufacturers of heated tobacco products have published a number of studies on their respective heated tobacco products. Whilst there is limited research that is independent of commercial interests, the available scientific evidence indicates that heated tobacco products produce a much simpler aerosol than conventional cigarette smoke, with fewer and substantially lower levels of harmful toxicants. Toxicology assessments indicate these reductions in aerosol toxicants translate to reduced biological effects. Biomarker and clinical data from studies in which product use is controlled within a clinical setting, indicate changes in biomarker levels and clinical end-points similar to observations in cessation studies, indicating the potential for reduced harm. The scientific evidence also indicates that exposure of non-users to emissions from heated tobacco products in indoor environments is significantly reduced compared to exposure resulting from smoking conventional cigarettes. Overall, the available scientific evidence indicates that heated tobacco products hold promise as a less harmful alternative to conventional cigarettes, but more independent data is required to validate industry findings. As a growing product category, epidemiological studies and independent population modelling studies are outstanding, and empirical data on how dual tobacco product category use by consumers affects their risk profile is lacking.

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Section: Nicotinementioning

confidence: 99%