Comparison of the disposition kinetics of lidocaine and ± prilocaine in 20 patients undergoing intravenous regional anaesthesia during day case surgery

Abstract

Results:The mean onset time of surgical analgesia of lidocaine was 11-2 ± 5*1 min and that of prilo caine was 10*9 ± 6 * 0 min. After releasing the tourniquet, lidocaine is bi-exponentially elim i nated with a tlj2a of 4*3 ± 2*1 min and a tlf2/} of 79*1 ± 31*2 min. Total body clearance was 0*86 dt 0*39 litres/min. Prilocaine is rapidly and bi-exponentially eliminated with a of 3*0 ± 1*6 min and a tll2^ o f 29-9 ± 1 5 * 7 min. The total body clearance of prilocaine is higher than that of lidocaine, 4*15 ± 1-31 vs. 0*86 ± 0*39 litres/min, respectively (P = 0*0007). Both compounds show comparable volum es of distribution (Fd, Vsa and Vp) and a comparable

Effect of articaine on mental nerve anterior portion: Histological analysis in rats

“…In addition, very few or no reports were attributed to lidocaine. Other followup studies have observed similar results [22][23][24][25][26]. So, it was suggested that an important cause of paresthesia could be related to the local anesthetic dosedependent neurotoxicity.…”

Effect of carticaine on the sarcoplasmic reticulum Ca 2+ -dependent adenosine triphosphatase

“…This local anesthetic of frequent use in dentistry is now slowly entering other fields (Van Oss et al 1989;Simon et al 1998). Carticaine was reported to be administered in over 37% of dental anesthesias in Canada (Haas and Lennon 1995) and 90% in Germany (Daublander et al 1997), and it is also widely used in Italy and The Netherlands (Oertel et al 1997).…”

Pharmacokinetics of Articaine Hydrochloride in Tumescent Local Anesthesia for Liposuction

“…12 Following infusion into the abdominal area and the hips, saturation of the esterases can be assumed, but not for infusion under the chin. Low systemic concentrations and rapid metabolization of articaine HCl also have been observed in a study comparing the effects of articaine and lidocaine in intravenous regional anesthesia, 18 in which large amounts of the drug are infused into the blood-drained extremities.…”