Comparison of the ease of tolerance induction in thymus and bone marrow of three strains of mice

Blackstock, Rebecca; Hyde, Richard M.

doi:10.1016/0008-8749(73)90168-8

Cited by 13 publications

(4 citation statements)

References 104 publications

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“…Cellmediated responses were not specifically evaluated. The classic model of tolerance induction in the HGG system with the dose of antigen used here is well-known to produce tolerance of T cells before the onset of tolerance of B cells (5,10). In addition, T-cell tolerance is longer-lasting than B-cell tolerance, which also requires higher doses of antigen for induction (10).…”

Section: Discussionmentioning

confidence: 99%

Induction of a macrophage-suppressive lymphokine by soluble cryptococcal antigens and its association with models of immunologic tolerance

Blackstock¹,

McCormack²,

Hall³

1987

Infect Immun

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Soluble extracts of Cryptococcus neoformans were examined for their ability to induce a macrophageregulatory T-suppressor cell known to appear in the spleens of mice infected with cryptococci. Suppressor cells were induced by injection of extracts of encapsulated or thinly encapsulated strains of cryptococci, Dose-response analysis showed that as little as 25 ,ug of soluble capsular polysaccharide antigen could induce significant suppressor cell activity, with maximum suppression occurring at a dose of 100 ,ug. The suppressor * Corresponding author.

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Section: Discussionmentioning

confidence: 99%

Induction of a macrophage-suppressive lymphokine by soluble cryptococcal antigens and its association with models of immunologic tolerance

Blackstock¹,

McCormack²,

Hall³

1987

Infect Immun

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“…Immunogenicity of ultracentrifugated proteins has already been reported in Balb/c (LukiE et al, 1975a), in adult SJL (Fujiwara & Cinader, 1974a) and ascribed to functional peculiarity of macrophages. In these strains resistance to tolerance induction is therefore, at least partially related to macrophage function (Blackstock & Hyde, 1973;Fujiwara & Cinader, 1974b). H mice are also resistant to high zone tolerance induction, though they are unresponsive to the two t-BSA doses used.…”

Section: Discussionmentioning

confidence: 99%

Tolerance Induction in Mice Selected for High or Low Antibody Responsiveness

Heumann

Stiffel

1980

Int J Immunogenetics

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Summary Induction of tolerance to bovine serum albumin was studied in mice selected for high (H) or low (L) antibody responsiveness and in their F1 hybrids. No high or low zone tolerances were obtained in H mice whereas L mice were susceptible to tolerance induction by the two schedules. H mice were immunized by repeated injections of tolerogenic BSA for low zone tolerance induction but not after the administration of a single high dose of tolerogenic BSA. Resistance to tolerance induction is dominant in F1 hybrids.

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“…BALB/c mice have been recognised to generally produce hyperreactive immune responses; tolerance induction is difficult to achieve in this strain, while it is easily achieved in C57BL/6 [3]. New Zealand Black mice are well known to be highly susceptible to autoimmunity [15,26].…”

Section: Discussionmentioning

confidence: 99%

Comparison of the immune response to sheep erythrocytes, tetanus toxoid and endotoxin in different strains of mice

Borel¹

1974

Agents and Actions

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The primary immune response in 7 inbred and 2 outbred mouse strains to SRBC, tetanus toxin and 'E. coli' endotoxin is compared. Significant variations are found in the different strains concerning their antibody response to these antigens.The differences in antibody production reached with SRBC (direct and indirect PFC) and tetanus toxin are on a quantitative level, those with endotoxin also on a qualitative level.The kinetic studies further indicate that course of antibody formation as well as peak of response may considerably vary between different strains.

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Comparison of the ease of tolerance induction in thymus and bone marrow of three strains of mice

Cited by 13 publications

References 104 publications

Induction of a macrophage-suppressive lymphokine by soluble cryptococcal antigens and its association with models of immunologic tolerance

Induction of a macrophage-suppressive lymphokine by soluble cryptococcal antigens and its association with models of immunologic tolerance

Tolerance Induction in Mice Selected for High or Low Antibody Responsiveness

Comparison of the immune response to sheep erythrocytes, tetanus toxoid and endotoxin in different strains of mice

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