Comparison of the effect of baclofen and transcutaneous electrical nerve stimulation for the treatment of spasticity in multiple sclerosis

Shaygannejad, Vahid; Janghorbani, Mohsen; Vaezi, Atefeh; Haghighi, Sepehr; Golabchi, Khodayar; Heshmatipour, Mojtaba

doi:10.1179/1743132813y.0000000200

Cited by 21 publications

(21 citation statements)

References 26 publications

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“…SBS might also be beneficial in rehabilitation techniques where peripheral electrical nerve stimulation has been proposed as a method to enhance motor or tactile sensation deficits (7,22) as well as in combination with standard rehabilitation programmes (23,24). Support for TENS over Baclofen was also noted previously with similar marginal decrease in MAS (25), although decrease of about 1 unit maybe of only minor clinical significance. This study investigated only the short-term effects of stimulation.…”

Section: Discussionsupporting

confidence: 59%

Sensory Barrage Stimulation in the Treatment of Elbow Spasticity: A Crossover Double Blind Randomized Pilot Trial

Slovak

Chindo

Nair

et al. 2016

Neuromodulation: Technology at the Neural Interface

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Section: Discussionsupporting

confidence: 59%

Sensory Barrage Stimulation in the Treatment of Elbow Spasticity: A Crossover Double Blind Randomized Pilot Trial

Slovak

Chindo

Nair

et al. 2016

Neuromodulation: Technology at the Neural Interface

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“…Studies using oral baclofen have reported significant improvement in flexion of the quadriceps in patients with MS when compared to a placebo (using the Ashworth scale 20 ) and subjective improvements in general function. 21,22 Furthermore, one study showed the protective effects of oral baclofen on the deterioration in body musculature and metabolic profile that normally accompany spastic individuals with SCI. 11 While there is a breadth of studies demonstrating the effectiveness of baclofen, most studies adhere to testing the drug in the setting of a specific condition, such as MS or SCI.…”

Section: Treatmentsmentioning

confidence: 99%

A Review of Spasticity Treatments: Pharmacological and Interventional Approaches

Chang

Ghosh

Yanni

et al. 2013

Crit Rev Phys Rehabil Med

175

134

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Spasticity is a velocity-dependent increase in muscle tone and uncontrolled, repetitive, involuntary contractions of skeletal muscles. Spasticity presents as upper motor neuron symptoms in patients with central nervous system pathology such as stroke, spinal cord injury, brain injury, or multiple sclerosis. As a result, a patient can have significant pain and limited mobility, which can lead to decreased quality of life and difficulty maintaining personal care. In this article we discuss mechanisms, indications, efficacy, and side effects of the most accepted current treatments. Currently available treatment options include oral medications and interventional procedures. Oral medications comprise centrally acting agents, such as baclofen, clonidine, and tizanidine, as well as anticonvulsants such as benzodiazepines and gabapentin and peripherally acting dantrolene. Interventional procedures include focal injections of botulinum toxin, phenol or alcohol, and an intrathecal baclofen pump. Surgical treatments include selective dorsal rhizotomy and neurectomy. We found that there are several treatments available with data to support their use, but many still need further research to prove their efficacy and develop optimal utilization.

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“…The results of this study showed that the application of TENS reduced spasticity in stroke patients. In previous studies, spasticity was significantly improved compared to the control group with baclofen when the high-frequency TENS was applied to the triceps surae and lateral malleolus of multiple sclerosis patients [32]. Another study reported that the low-frequency TENS applied on gastrocnemius muscle and achilles tendon of CVA patients had a lower MAS score than the sham therapy [33].…”

Section: Discussionmentioning

confidence: 94%

The Effects of High Frequency Transcutaneous Nerve Stimulation on Spasticity, Proprioception, Strength, and Balance in Patients with Stroke : A Randomized Controlled Trial

Lee¹,

Cha²

2019

JMAG

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This study was conducted to compare the effects of high frequency and low frequency transcutaneous electrical nerve stimulation applied to gastrocnemius muscle on proprioception, spasticity, and dynamic balance of stroke patients. Twenty subjects were randomly assigned to each of 10 experimental and control groups. High frequency transcutaneous electrical nerve stimulation was applied to the experimental group and low frequency transcutaneous electrical nerve stimulation was applied to the control group for 20 minutes per day, 5 times a week for a total of 4 weeks. The subjects were assessed for proprioception by joint position sense in ankle plantarflexion and dorsiflexion, spasticity was assessed using Modified Ashworth Scale (MAS) and amount of resistance, and dynamic balance was assessed using the Timed Up and Go (TUG) test. A significant improvement in joint position sense (plantarflexion, dorsiflexion), MAS, amount of resistance, and TUG was observed after intervention in the experimental group (p < 0.05), and there was a significant improvement in all evaluation items compared to the control group (p < 0.05). The results of this study suggest that application of high frequency transcutaneous electrical nerve stimulation to the bilateral gastrocnemius muscles of patients with stroke has a positive effect on proprioception, spasticity and dynamic balance.

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Comparison of the effect of baclofen and transcutaneous electrical nerve stimulation for the treatment of spasticity in multiple sclerosis

Abstract: This study demonstrates that both baclofen and TENS can be effective in reducing MS-related spasticity. The mean MAS score was significantly lower in the TENS group. However given the side-effect profile of baclofen, TENS may have some benefits over baclofen.

Cited by 21 publications

References 26 publications

Sensory Barrage Stimulation in the Treatment of Elbow Spasticity: A Crossover Double Blind Randomized Pilot Trial

Sensory Barrage Stimulation in the Treatment of Elbow Spasticity: A Crossover Double Blind Randomized Pilot Trial

A Review of Spasticity Treatments: Pharmacological and Interventional Approaches

The Effects of High Frequency Transcutaneous Nerve Stimulation on Spasticity, Proprioception, Strength, and Balance in Patients with Stroke : A Randomized Controlled Trial

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