Comparison of the Effect of Viral Paramunity Inducers PIND‐AVI and PIND‐ORF with that of BCG, <i>Corynebacterium parvum</i> and Levamisole on the Growth of Radiation‐Induced Murine Osteosarcoma

Müller-Brunecker, G.; Erfle, V.; Mayr, Anton

doi:10.1111/j.1439-0450.1986.tb00022.x

Cited by 6 publications

(2 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Cell-mediated immunity accompanies chemotherapy-associated regression in CTVT (33). Immunostimulators (paramunity activators) have been tried in several tumours and some of them have produced positive results (9,62).…”

Section: Evaluation Of Ctvt Stagementioning

confidence: 99%

Canine transmissible venereal tumour: Cytogenetic origin, immunophenotype, and immunobiology. A review

Mukaratirwa¹,

Gruys

2003

Veterinary Quarterly

View full text Add to dashboard Cite

Canine transmissible venereal tumour (CTVT) is the only known naturally occurring tumour that can be transplanted as an allograft across major histocompatibility (MHC) barriers within the same species, and even to other members of the canine family, such as foxes, coyotes and wolves. The progression of this tumour is unique in that, it follows a predictable growth pattern. In natural and experimental cases, the growth pattern includes progressive growth phase, static phase and regression phase, and this is followed by transplantation immunity in immunocompetent adults, while metastasis occurs in puppies and immunosuppressed dogs. Because of the uniqueness of CTVT transmission and progression, experimental investigations of various aspects of the biology of CTVT have been used to provide clues to the immunobiology of both animal and human tumours. This review examines the current state of knowledge of the aspects of the cytogenetic origin, immunophenotype, immunobiology and immunotherapy of CTVT.

show abstract

Section: Evaluation Of Ctvt Stagementioning

confidence: 99%

Canine transmissible venereal tumour: Cytogenetic origin, immunophenotype, and immunobiology. A review

Mukaratirwa¹,

Gruys

2003

Veterinary Quarterly

View full text Add to dashboard Cite

show abstract

“…Speziell betrifft dies Herpesviruserkrankungen, Papillome, chronische Hautkrankheiten, Erkran-U.S. Copyright Clearance Center Code Statement: 0931 -1793/89/3602 -0081$02.50/0 kungen des Hals-, Nasen-und Ohrenbereiches und andere progredierende Krankheiten bis hin zu Tumoren (1,3,7,30). Es gibt eine Fulle von nicht veroffentlichten Protokollen der verschiedensten Impfarzte, die hieriiber berichten.…”

Section: Einfiihrungunclassified

Experimenteller Nachweis paraspezifischer Wirkungen von gereinigten und inaktivierten Pockenviren

Mayr

Büttner

Wolf

et al. 1989

Journal of Veterinary Medicine, Series B

Self Cite

View full text Add to dashboard Cite

Experimental proof of paraspecific effects of purified and inactivated pox virusThe paraspecific effect of pox viruses i. e. stimulation of the nonspecific part of the complex immune system, was demonstrated in vitro and in vivo for 3 different types of virus (vaccinia virus, avipox virus, parapox virus). By means of purification, concentration and inactivation, it was possible to prove that the paraspecific effect is brought about by the pox virus particle per se. The effect is induced by certain epitopes in the complex structure of the virus and is independent of virus multiplication.Both purified pox viruses and inactivated, purified pox viruses stimulate NK cell activity, the CSA and the formation of interferon, and reach higher efficacy indices in a challenge test with baby mice using stomatitis vesicularis virus than non-purified and non-inactivated cell culture material.The degree of purity of the pox V~N S preparations was established using the electron microscope and monoclonal antibodies. The purified and concentrated pox virus preparations proved to be pyrogen-free; they were not toxic to baby mice in vivo. An endotoxin-induced effect could be ruledThe broad paraspecific effect of pox viruses and their structural components lends itself to use as out.paramunity inducers in prophylaxis and therapy.

show abstract

Vergleichende Untersuchungen über die immunstimulierende (paramunisierende) Wirksamkeit von BCG, Levamisol, Corynebacterium parvum und Präparaten aus Pockenviren in verschiedenen “in vivo”‐und “in vitro”‐Testen

Mayr

Büttner

Pawlas

et al. 1986

Journal of Veterinary Medicine, Series B

View full text Add to dashboard Cite

Summary Comparative studies on the immunostimulating (paramunizing) effectiveness of BCG, levamisole, Corynebacterium parvum and preparations of pock viruses in various in vitro and in vivo tests There are 3 classical immunostimulants: BCG, levamisole and C. parvum. For some years in veterinary medicine two immunostimulants from pock or parapock viruses have been employed as paramunity inducers with success (PIND‐AVI, PIND‐ORF). In order to explore in detail the functional bases of the above preparations, they were compared by the following tests: 1. In 2 infection models (vesicular stomatitis and Aujesky virus; 2. In a tumour model (radiation induced osteosarcoma in the mouse); 3. The chromium 51 test to demonstrate spontaneous (natural) cytotoxicity; 4. An indirect plaque reduction test to detect stimulation from interferon; and 5. The lymphocyte transformation test. The results showed that the effect of the individual immunostimulants can vary very widely. Both paramunity inducers were effective in all the 5 tests and were harmless. PIND‐AVI, however, activated above all the lymphocyte, whereas PIND‐ORF had NK (natural mouse spleen killer cells) activity and was the only one of the 5 immunostimulants which also stimulated interferon production. C. parvum, BCG and levamisole were significantly less effective and they were also pyrogenic and in some cases also toxic. The main point arising from the study is that when using immunostimulants it is essential to know precisely how they act and also the damaging effects of the individual agents if the desired effects are to be achieved without harm to the patients. The 5 test systems which we used seem to be the ones of choice for the purpose. Special attention is directed to preparations of pock viruses which act as harmless but effective immunostimulants. Zusammenfassung Es gibt drei klassische Immunstimulantien: BCG, Levamisol und C. parvum. In der Tiermedizin werden seit Jahren 2 Immunstimulantien, die aus Pocken‐ bzw. Parapockenviren hergestellt werden, als sog. Paramunitätsinducer mit Erfolg verwendet (PIND‐AVI, PIND‐ORF). Um die funktionellen Grundlagen obiger Präparate detailliert erfassen zu können, sind sie in folgenden Testen vergleichend untersucht worden: 1. in 2 Infektionsmodellen (Stomatitis vesicularis‐, Aujeszky‐Virus), 2. in einem Tumormodell (strahleninduziertes Osteosarkom der Maus), 3. im Chromium 51‐Test zum Nachweis der spontanen, natürlichen Zytotoxizität, 4. im indirekten Plaque‐Reduktions‐Test zum Nachweis der Stimulierung von Interferon und 5. im Lymphozyten‐Transformationstest. Die Untersuchungsergebnisse weisen darauf hin, daß die Wirkung der einzelnen Immunstimulantien sehr unterschiedlich sein kann. Die beiden Paramunitätsinducer waren in allen Testen wirksam und unschädlich. Trotzdem unterschieden sie sich. PIND‐AVI aktivierte vor allem die Lymphozyten, während PIND‐ORF besonders die NK‐Aktivität und, als einziges der 5 Präparate, auch die Interferonbildung stimulierte. C. parvum, BCG und Levamisol schnitten wesentlich schlechter ab, w...

show abstract

Comparison of the Effect of Viral Paramunity Inducers PIND‐AVI and PIND‐ORF with that of BCG, Corynebacterium parvum and Levamisole on the Growth of Radiation‐Induced Murine Osteosarcoma

Cited by 6 publications

References 9 publications

Canine transmissible venereal tumour: Cytogenetic origin, immunophenotype, and immunobiology. A review

Canine transmissible venereal tumour: Cytogenetic origin, immunophenotype, and immunobiology. A review

Experimenteller Nachweis paraspezifischer Wirkungen von gereinigten und inaktivierten Pockenviren

Vergleichende Untersuchungen über die immunstimulierende (paramunisierende) Wirksamkeit von BCG, Levamisol, Corynebacterium parvum und Präparaten aus Pockenviren in verschiedenen “in vivo”‐und “in vitro”‐Testen

Contact Info

Product

Resources

About