“…Chewing gum was the most common form among studies and may have been chosen due to its greater acceptance by the general population. The more recent studies exhibited a positive effect of xylitol gums for antimicrobial activity [22,23,25,26,30,82], dental caries [30,82], dental biofilm [23,31,82], periodontal condition [23,30,31], salivary parameters [26,30,67], and gastric emptying [12]. The presentation forms less common are aerosol, tested for treat acute rhinopharyngitis in children, but without positive effect [83]; cream to treat atopic dermatitis and Staphylococcus aureus in the skin of adults [84], and milk to control S. mutans in children's biofilm and saliva [18,85].…”