Comparison of the effects of BPA and BPAF on oocyte spindle assembly and polar body release in mice

Nakano, Kaori; Nishio, Manami; Kobayashi, Norio; Hiradate, Yuuki; Hoshino, Yumi; Sato, Eimei; Tanemura, Kentaro

doi:10.1017/s0967199415000027

Cited by 33 publications

(30 citation statements)

References 47 publications

(63 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…However, it was only possible to determine whether these effects were attributable to a slowing of the cell cycle or meiotic maturation blockade after culture was prolonged beyond 48 h. Significantly, a proportion of oocytes exposed to BPS remained in the MI or anaphase I/telophase I stages. Therefore, BPS not only causes a slowing of pig oocyte maturation in vitro , similar to that observed during the maturation of mouse oocytes in the presence of BPA 26 or bisphenol AF 27 , but BPS also permanently blocks the course of maturation in a significant portion of oocytes. Similar effects have been observed for the maturation of pig oocytes in BPA presence 24 .…”

Section: Discussionmentioning

confidence: 53%

Bisphenol S negatively affects the meotic maturation of pig oocytes

Žalmanová¹,

Hošková²,

Nevoral³

et al. 2017

Sci Rep

View full text Add to dashboard Cite

Bisphenol A (BPA), a chemical component of plastics, is a widely distributed environmental pollutant and contaminant of water, air, and food that negatively impacts human health. Concerns regarding BPA have led to the use of BPA-free alternatives, one of which is bisphenol S (BPS). However, the effects of BPS are not well characterized, and its specific effects on reproduction and fertility remain unknown. It is therefore necessary to evaluate any effects of BPS on mammalian oocytes. The present study is the first to demonstrate the markedly negative effects of BPS on pig oocyte maturation in vitro, even at doses lower than those humans are exposed to in the environment. Our results demonstrate (1) an effect of BPS on the course of the meiotic cell cycle; (2) the failure of tubulin fibre formation, which controls proper chromosome movement; (3) changes in the supply of maternal mRNA; (4) changes in the protein amounts and distribution of oestrogen receptors α and β and of aromatase; and (5) disrupted cumulus cell expansion. Thus, these results confirm that BPS is an example of regrettable substitution because this substance exerts similar or even worse negative effects than those of the material it replaced.

show abstract

Section: Discussionmentioning

confidence: 53%

Bisphenol S negatively affects the meotic maturation of pig oocytes

Žalmanová¹,

Hošková²,

Nevoral³

et al. 2017

Sci Rep

View full text Add to dashboard Cite

show abstract

“…BPA exposure suppressed polar body release in mice [31], and exposure to BPA during in vitro oocyte maturation could decrease oocyte quality in Bos taurus [32]. In addition, there was a dose-response association of BPA exposure as for altering the maturation of human oocytes in vitro [22].…”

Section: Discussionmentioning

confidence: 99%

“…Our results indicated that similar with other models, BPA had directly toxic effects on porcine oocytes in vitro , but not DEHP. In mice, oocytes exposed to high doses of BPA experienced a cell cycle delay, and managed to progress to MII when the culture period was prolonged [31]. And short exposure to BPA during the final stages of oocyte maturation is associated with cell cycle delays and spindle abnormalities [17, 22, 33].…”

Section: Discussionmentioning

confidence: 99%

The toxic effects and possible mechanisms of Bisphenol A on oocyte maturation of porcine in vitro

et al. 2016

View full text Add to dashboard Cite

Bisphenol A (BPA) and Di-(2-ethylhexyl) phthalate (DEHP) are widely used in the plastic industry such as water bottles, containers, packaging and toys. BPA and DEHP are shown to be the endocrine disruptors which disturb the endocrine system and are linked to several diseases including infertility. In this study, we investigated the effects of BPA exposure on porcine oocyte maturation and its possible reasons. Our results showed that: (i) the rates of oocyte maturation significantly decreased with 250 μM BPA treatment in vitro, but not DEHP. This might be due to the delayed cell cycle progression of oocyte maturation. (ii) BPA treatment resulted in abnormal cytoskeletons on porcine oocytes, showing with aberrant actin distribution, spindle morphology and chromosome alignment, which was further confirmed by the reduced p-MAPK level. (iii) The fluorescence intensity of histone methylation (H3K4me2) and DNA methylation (5 mC) levels were altered after BPA treatment, indicating that epigenetic modification was disturbed. (iv) BPA-exposed oocytes had higher rates of early stage apoptosis/autophagy, and this may be resulted from the increased level of oxidative stress. Collectively, our results indicated that porcine oocytes maturation was disrupted after BPA treatment through disrupting cytoskeletal dynamics, epigenetic modifications and inducing apoptosis/autophagy.

show abstract

“…However, the limited data from reproductive and other tissues provide preliminary evidence that, like BPA, other bisphenols induce developmental effects ([73–75]; reviewed in Rochester and Bolden [76]). For example, BPS and BPF exposure exert effects similar to those reported for BPA on testis gene expression and steroidogenesis in male rats (77); BPAF exposure disrupts mouse oocyte maturation to a similar or greater extent than BPA (42); studies in zebrafish show that the effects of BPS on the reproductive neuroendocrine pathway are similar to BPA (78). However, as with BPA, the nature of the specific effects of exposure undoubtedly depends on the developmental timing of exposure and the tissue examined.…”

Section: Bpa-free: New Problems Not Solutionsmentioning

confidence: 89%

“…The first reported effect of BPA on the oocyte was of an exposure to the periovulatory follicle and an effect on meiotic chromosome alignment and segregation that increased the incidence of chromosomally abnormal eggs in mice (7). Numerous subsequent studies (reviewed in Peretz et al [16] and see [42–44]) have provided support for the detrimental effects of BPA on oocyte maturation. Thus, there is ample evidence that the periovulatory oocyte in a range of species—including humans—is vulnerable to the effects of BPA exposure.…”

Section: The Ovary: Vulnerability At Multiple Stagesmentioning

confidence: 99%

An old culprit but a new story: bisphenol A and “NextGen” bisphenols

Sartain

Hunt

2016

Fertility and Sterility

View full text Add to dashboard Cite

The concept that developmental events shape adult health and disease was sparked by the recognition of a link between maternal undernutrition and coronary disease in adults. From that beginning, a new field—the developmental origins of health and disease—emerged, and attention has focused on the effects of a wide array of developmental perturbations. Exposure to endocrine-disrupting chemicals has been of particular interest, and a ubiquitous environmental contaminant bisphenol A (BPA) has become the endocrine-disrupting chemical poster child. Bisphenol A has been the subject of intense investigation for nearly two decades, and exposure effects have been described in hundreds of experimental, epidemiological, and clinical studies. From the standpoint of reproductive health, the findings are particularly important, as they suggest that the ovary, testis, and reproductive tract in both sexes are targets of BPA action. The findings and the media and regulatory attention garnered by them have generated increasing public concern and resulted in legislative bans on BPA in some countries. The subsequent introduction of BPA-free products, although a masterful marketing strategy, is in reality only the beginning of a new and complex chapter of the BPA story. In this review we attempt to summarize what we have learned about the reproductive effects of BPA, present the reasons why studying the effects of this chemical in humans is no longer sufficient, and outline the challenges that the growing array of next generation bisphenols represents to clinicians, researchers, federal agencies, and the general public.

show abstract

Comparison of the effects of BPA and BPAF on oocyte spindle assembly and polar body release in mice

Cited by 33 publications

References 47 publications

Bisphenol S negatively affects the meotic maturation of pig oocytes

Bisphenol S negatively affects the meotic maturation of pig oocytes

The toxic effects and possible mechanisms of Bisphenol A on oocyte maturation of porcine in vitro

An old culprit but a new story: bisphenol A and “NextGen” bisphenols

Contact Info

Product

Resources

About