Comparison of the effects of levocetirizine and losartan on diabetic nephropathy and vascular dysfunction in streptozotocin-induced diabetic rats

Anbar, Hanan S.; Shehatou, George S.G.; Suddеk, Ghada M.; Gameil, Nariman M.

doi:10.1016/j.ejphar.2016.03.035

Cited by 22 publications

(37 citation statements)

References 76 publications

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“…Only two studies have investigated the effect of an antihistaminergic approach on DN, both in recent years. These studies suggest that histamine is involved in renal injury and both the selective histamine antagonism, at H 1 R by levocetirizine (56), and at H 4 R by JNJ39758979 (19), were able to prevent/reduce renal damage.…”

Section: Resultsmentioning

confidence: 88%

“…Nevertheless, H 1 R can also modulate the fibrotic response. Indeed, levocetirizine-treated diabetic rats have shown a reduction in renal TGF-β1 (56). Whether this is a direct consequence of H 1 R antagonism, or rather an indirect event is still to be established.…”

Section: Histamine and Glomerular Hyper-filtrationmentioning

confidence: 99%

“…Whether this is a direct consequence of H 1 R antagonism, or rather an indirect event is still to be established. However, the anti-inflammatory effect, evaluated in terms of the restoration of TNF-α levels and nitric oxide (NO) bioavailability (56), may be a possible mechanistic interpretation of the anti-fibrotic result. Moreover, the presence of the H 1 R on kidney fibroblasts, whose activation promotes proliferation, TGF-β synthesis and collagen production (Silver -2013), further support the involvement of this receptor in fibrosis development.…”

Section: Histamine and Glomerular Hyper-filtrationmentioning

confidence: 99%

“…It is therefore possible that histamine may also modulate AQP expression, via H 1 R and/or other HRs, in other epithelial cells, such as renal epithelial cells, according to their differential distribution. A deeper investigation of this issue would contribute to better understanding the mechanism that underlies the anti-polyuric effect that is exerted by both levocetirizine (56), and JNJ39758979 (19).…”

Section: Histamine and Glomerular Hyper-filtrationmentioning

confidence: 99%

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Histamine and diabetic nephropathy: an up-to-date overview

et al. 2019

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The classification of diabetic nephropathy (DN) as a vascular complication of diabetes makes the possible involvement of histamine, an endogenous amine that is well known for its vasoactive properties, an interesting topic for study. The aim of the present review is to provide an extensive overview of the possible involvement of histamine in the onset and progression of DN. The evidence collected on the role of histamine in kidney function together with its well-known pleiotropic action suggest that this amine may act simultaneously on glomerular hyperfiltration, tubular inflammation, fibrosis development and tubular hypertrophy.

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Section: Resultsmentioning

confidence: 88%

Section: Histamine and Glomerular Hyper-filtrationmentioning

confidence: 99%

Section: Histamine and Glomerular Hyper-filtrationmentioning

confidence: 99%

Section: Histamine and Glomerular Hyper-filtrationmentioning

confidence: 99%

See 2 more Smart Citations

Histamine and diabetic nephropathy: an up-to-date overview

et al. 2019

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“…27 SD rats were randomly divided into 3 groups: normal control group (NC group), vascular calcification group (MC group) and resveratrol treated vascular calcification group (Treatment group). MC group: warfarin (150 mg/kg) combined with vitamin K1 (15 mg/kg) subcutaneous injection at 8 a.m.; warfarin was re injected once again at 8 p.m., continued for 2 weeks (13,14). Treatment group: Rats were given subcutaneous injections of warfarin for first weekends and treated with resveratrol (100 mg/kg) for 1 week (15,16).…”

Section: Establishment Of Rat Model Of Vascular Calcificationmentioning

confidence: 99%

白藜芦醇改善动脉粥样硬化的体内研究

朱玲俐¹,

官宗华²,

张世亮³

et al. 2019

Advances in Biology and Medicine

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Aim:The aim of this study is to explain the effects and mechanism of resveratrol to improve atherosclerosis in vivo study.Methods: SD rats were divided randomly into control group, vascular calcification model group and treatment group. Vascular calcification models were made by subcutaneous injection of warfarin plus vitamin K1 for two weeks. Rats in the treatment group were subcutaneously injected with resveratrol ( 10 mg/kg) at the end of the first week and consecutively for two weeks．We observed the morphological changes by HE staining and the calcium deposition by Alizarin red staining in the artery vascular wall．The AT1R, RUNX2 and BMP2 proteins expressions were evaluated by WB assay. The apoptosis of smooth muscle cells (SMCs) were detected by TUNEL. Results:The aortic vascular calcification was induced by warfarin and vitamin K1. Compared with the vascular calcification model group，the protein expressions of AT1R, BMP2 and RUNX2 were significantly downregulated in the aorta in the resveratrol treatment group． Furthermore, the apoptosis of SMCs was obviously decreased in resveratrol treatment group． Conclusion: Resveratrol inhibited apoptosis of SMCs via regulation AT1R; It downregulates the BMP2 and RUNX2 expressions in the vascular calcification process． advbiomed.0005.

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Tetrahydrocurcumin Add‐On therapy to losartan in a rat model of diabetic nephropathy decreases blood pressure and markers of kidney injury

Khazaeli

Nunes

Zhao

et al. 2023

Pharmacology Res & Perspec

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Tetrahydrocurcumin (THC), a principal metabolite of curcumin, was tested in a rat model of type 2 diabetes mellitus. THC was administered via daily oral gavage with the lipid carrier polyenylphosphatidylcholine (PPC) as add‐on therapy to losartan (angiotensin receptor blocker) to examine effects on kidney oxidative stress and fibrosis. A combination of unilateral nephrectomy, high‐fat diet and low‐dose streptozotocin was used to induce diabetic nephropathy in male Sprague–Dawley rats. Animals with fasting blood glucose >200 mg/dL were randomized to PPC, losartan, THC + PPC or THC + PPC + losartan. Untreated chronic kidney disease (CKD) animals had proteinuria, decreased creatinine clearance, and evidence of kidney fibrosis on histology. THC + PPC + losartan treatment significantly lowered blood pressure concurrent with increased messenger RNA levels of antioxidant copper‐zinc‐superoxide dismutase and decreased protein kinase C‐α, kidney injury molecule‐1 and type I collagen in the kidneys; there was decreased albuminuria and a trend for increased creatinine clearance compared to untreated CKD rats. There was decreased fibrosis on kidney histology in PPC‐only and THC‐treated CKD rats. Plasma levels of kidney injury molecule‐1 were decreased in THC + PPC + losartan animals. In summary, add‐on THC to losartan therapy improved antioxidant levels and decreased fibrosis in the kidneys, and lowered blood pressure in diabetic CKD rats.

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Comparison of the effects of levocetirizine and losartan on diabetic nephropathy and vascular dysfunction in streptozotocin-induced diabetic rats

Cited by 22 publications

References 76 publications

Histamine and diabetic nephropathy: an up-to-date overview

Histamine and diabetic nephropathy: an up-to-date overview

白藜芦醇改善动脉粥样硬化的体内研究

Tetrahydrocurcumin Add‐On therapy to losartan in a rat model of diabetic nephropathy decreases blood pressure and markers of kidney injury

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