Comparison of the effects of propofol and pentobarbital on hydrogen peroxide-stimulated hepatic SNU761 cells

Lee, Ji Yeon; Shin, Jin-Woo; Lee, Eun‐Ho; Baek, Seung-Hye; Ku, Seung Woo; Kim, Joung Uk

doi:10.4097/kjae.2010.58.3.277

Cited by 7 publications

(9 citation statements)

References 25 publications

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“…Although Shimono et al, [16], found no evidence for a beneficial effect of propofol against liver hypoxia/reoxygenation injury in rat liver slices, propofol was shown to protect suspensions of isolated rat hepatocytes from an oxidant insult [12]. Moreover, Lee et al, [34], found that propofol, but not pentobarbital, exerts a protective effect on hepatocytes exposed to H 2 O 2 oxidant stress in vitro. Reasons for these discrepancies may include the use of different experimental models.…”

Section: Discussionmentioning

confidence: 99%

“…Since it has shown that propofol increased hepatic blood flow in a dose dependent manner [35], the hepatoprotective effect of propofol may be also dose-dependent. Lee et al, [34], found that propofol has a protective effect on hepatocytes in a clinically relevant concentrations of 1-50 M, because peak plasma concentrations of propofol are reportedly 40-60 M (7.12-10.68 g/mL) at anesthesia induction and 10-25 M (1.78-4.45 g/mL) during anesthesia maintenance [42]. de la Cruz et al, [13], reported that 50-300 M, but not 10 M, propofol had significant effects on all the oxidative-stress variables they studied in rat brain slices.…”

Section: Discussionmentioning

confidence: 99%

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Propofol Protects against Ischemia/Reperfusion Injury Associated with Reduced Apoptosis in Rat Liver

Abdel-Wahab

Al-Harizy

2013

ISRN Anesthesiology

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Propofol is an intravenous anesthetic, reported to have a protective effect against ischemia/reperfusion (I/R) injury in heart and brain, but no definite data are available concerning its effect in hepatic I/R. This work investigated the effect of propofol anesthesia on hepatic I/R injury using in vivo rat model. Four groups of rats were included: sham operated, I/R (30 min ischemia and 2 h reperfusion), I/R treated with propofol (10 mg/kg/h), and I/R treated with propofol (20 mg/kg/h). Liver enzyme leakage, TNFand caspase-3 levels, and antiapoptotic Bcl-xL/apoptotic Bax gene expression, together with histopathological changes, were used to evaluate the extent of hepatic I/R injury. Compared with sham-operated group, I/R group showed significant increase in serum levels of liver enzymes (ALT, AST), TNF-, and caspase-3 and significant decrease in the Bcl-xL/Bax ratio, associated with histopathologic damage in liver. Propofol infusion significantly attenuated these changes with reduced hepatic histopathologic lesions compared with nonpreconditioned I/R group. However, no significant differences were found between two groups treated with different doses of propofol. In conclusion, propofol infusion reduced hepatic I/R injury with decreased markers of cellular apoptosis. Therefore, propofol anesthesia may provide a useful hepatic protection during liver surgery.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Propofol Protects against Ischemia/Reperfusion Injury Associated with Reduced Apoptosis in Rat Liver

Abdel-Wahab

Al-Harizy

2013

ISRN Anesthesiology

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“…Therefore, it is suggested that the benefits of nutrient interventions seen in oxidative stress resistance may extend from cancer prevention to therapeutic intervention [92,93]. A series of recent studies by Longo et al have shown that fasting can selectively protect healthy cells while sensitizing tumor cells to drug treatment.…”

Section: Introdcutionmentioning

confidence: 99%

Metabolic regulation of Sirtuins upon fasting and the implication for cancer

Zhu¹,

Yan²,

Gius³

et al. 2013

Current Opinion in Oncology

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Purpose of review The purpose of this review is to highlight recent studies on mammalian sirtuins that coordinately regulate cellular metabolic homeostasis upon fasting and to summarize the beneficial effects of fasting on carcinogenesis and cancer therapy. Recent findings Recent studies have demonstrated that fasting may protect normal cells and mice from the metabolic conditions that are harmful as well as decrease the incidence of carcinogenesis. Fasting could also slow the tumor growth and augment the efficacy of certain systemic agents/chemotherapy drugs in various cancers. The mechanism behind this proposed idea may be due to, at least in some part, the metabolic regulation by sirtuin family proteins whose functions are involved in specific aspects of longevity, stress response and metabolism. Sirtuins, particularly SIRT1 and SIRT3, can be activated by fasting and further exhibit their effects in insulin response, antioxidant defense, and glycolysis. Therefore, sirtuins may have anticancer effects by shifting metabolism to a less proliferative cell phenotype as well as less prone to oxidative stress attack. Summary The in-depth understanding of the essential role of sirtuins in the fasting process may have significant implications in developing a new metabolic diagram of cancer prevention or treatment.

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“…[26] Moreover, previous studies confirmed that propofol has a hepatoprotective effect through its role in reduction of free radical generation and free radical scavenging, dumping of inflammatory reactions. [32,33] It has inhibitory effects on calcium channels and diminution of intracellular calcium overload , improved microcirculation through reported induced nitric oxide (NO) and vasodilatory prostanoid production. [33,34] ROC curves revealed that miR-122 had the highest efficiency in prediction of ischemia/reperfusion injury followed by miR-223.…”

Section: Discussionmentioning

confidence: 99%

“…[32,33] It has inhibitory effects on calcium channels and diminution of intracellular calcium overload , improved microcirculation through reported induced nitric oxide (NO) and vasodilatory prostanoid production. [33,34] ROC curves revealed that miR-122 had the highest efficiency in prediction of ischemia/reperfusion injury followed by miR-223. These findings suggested that estimation of plasma miR-122 and miR-223 in CHC undertaking anesthesia could be an early, and reliable biomarker for predicting I/R liver injury.…”

Section: Discussionmentioning

confidence: 99%

MicroRNAs versus traditional biomarkers in predicting reperfusion injury in Hepatitis C Patients after major surgery

Demerdash

Arida

Zanaty

et al. 2018

APALM

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Background: Exposure to anesthesia in patients with chronic hepatitis C (CHC) may induce hepatic ischemia / reperfusion (I/R) with subsequent biochemical changes, provoked by alteration in molecular processes. This study explored miR-122 and miR-223 expression changes induced by anesthesia in CHC patients and their role in predicting hepatic I/R injury. Methods:This study included two hundered ASA II -III adult patients, scheduled for major surgery under general anesthesia. Patients were divided into 2 main groups; CHC patients group and non-hepatitis patients group. Each group was further divided into 2 equal subgroups (50 patients each) according to type of anesthesia received either Sevoflurane SC /S or Propofol PC/P ). Blood samples were analyzed for liver enzymes, prothrombin time, and serum lactate at several intervals; preoperative, 12 and 48 hours postoperative. Also, plasma miR-122 and miR-223 were estimated by Reverse Transcription PCR preoperative and 12 hours postoperative.Results: CHC groups showed significantly increased preoperative expression of both miR-122 and miR-223 compared to non-hepatitis groups (P<0.05). Moreover, postoperative samples revealed more exaggerated expression miR-122 and miR-223. Receiver operating characteristic curve (ROC) results revealed;values for area under the ROC for miR-122, miR-223, ALT and serum Lactate were 0.991, 0.965, 0.746 and 0.732 respectively. Based on the ROC finding, for prediction IR in CHC patients receiving anesthesia miR-122 had best Accuracy, sensitivity, and specificity. Conclusion:Our results suggested that both miR-122 and miR-223 could be regarded as more sensitive and specific biomarkers for predicting hepatic I/R injury than traditional biomarkers particularly in CHC patients undergoing major surgery.

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Comparison of the effects of propofol and pentobarbital on hydrogen peroxide-stimulated hepatic SNU761 cells

Cited by 7 publications

References 25 publications

Propofol Protects against Ischemia/Reperfusion Injury Associated with Reduced Apoptosis in Rat Liver

Propofol Protects against Ischemia/Reperfusion Injury Associated with Reduced Apoptosis in Rat Liver

Metabolic regulation of Sirtuins upon fasting and the implication for cancer

MicroRNAs versus traditional biomarkers in predicting reperfusion injury in Hepatitis C Patients after major surgery

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