Comparison of the Effects of Different Intravenous Fat Emulsions in Patients With Systemic Inflammatory Response Syndrome and Sepsis

Sungurtekin, Hülya; Değirmenci, Sezai; Sungurtekin, Uğur; Oguz, Berna Elibol; Sabir, Nuran; Kaptanoǧlu, Bünyamin

doi:10.1177/0884533611418783

Cited by 39 publications

(33 citation statements)

References 29 publications

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“…Most of the studies were focused on middle-aged surgical or critically ill patients. Seven (44%) of the 16 studies found some positive results for LETs or liver ultrasound tests in patients receiving IVLEs containing FO (8,11,12,15,16,19,21). Studies using FO in doses of ≥ 0.150 mg/kg/day presented more positive results than those with lower doses.…”

Section: Potential Benefits Prevention Of Alterations In Liver Enzymementioning

confidence: 99%

“…Several prospective studies have been published assessing the preventive effect of IVLEs containing FO on alterations in LETs or PNALD (6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21). Characteristics of these studies are shown in table I.…”

Section: Potential Benefits Prevention Of Alterations In Liver Enzymementioning

confidence: 99%

“…Two (40%) of the five studies with this IVLE rendered some positive results (15,19). Only one study tested an IVLE containing exclusively FO 100% administered in high doses, which lead to improved liver ultrasound test and better lactate dehydrogenase (LDH) in septic patients (12). Two additional studies tested a combination of an IVLE exclusively composed of FO 100% and an already marketed IVLE without FO.…”

Section: Potential Benefits Prevention Of Alterations In Liver Enzymementioning

confidence: 99%

“…Prospective studies collecting data on plasma clearance of IVLEs containing FO are presented in table II (6)(7)(8)(12)(13)(14)16,17,(19)(20)(21)(30)(31)(32)(33)(34).…”

Section: Plasma Lipid Clearancementioning

confidence: 99%

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Effects unrelated to anti-inflammation of lipid emulsions containing fish oil in parenteral nutrition for adult patients

Joaquín¹,

Florit-Sureda²

2017

Nutr Hosp

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Mateu-de-Antonio J, Florit-Sureda M. Effects unrelated to anti-infl ammation of lipid emulsions containing fi sh oil in parenteral nutrition for adult patients. Nutr Hosp 2017;34:193-203 ResumenSe han publicado varias revisiones y metaanálisis sobre la modulación de las respuestas infl amatorias e inmunológicas por la administración de ácidos grasos poliinsaturados (AGPI) omega-3. Sin embargo, los AGPI omega-3 ejercen otras acciones no directamente relacionadas con estas respuestas. El objetivo de este trabajo es revisar los efectos de las emulsiones lipídicas intravenosas (ELIV) que contienen aceite de pescado (AP) en la nutrición parenteral (NP) de pacientes adultos. Estas emulsiones pueden tener un papel importante en la prevención de las alteraciones del perfi l hepático o de la enfermedad hepática asociada a la NP (EHANP) en comparación con las ELIV sin AP. Los estudios que usaron dosis ≥ 0,150 mg/kg/día presentaron resultados más positivos que aquellos con dosis menores. Una vez se ha presentado la EHANP, el uso de una ELIV compuesta exclusivamente de AP, a dosis de 0,25-1 g de AP/kg/día durante varias semanas, podría atenuar o incluso revertir la alteración hepática y la colestasis cuando la administración de la NP es crónica. Las ELIV con AP parecen tener un aclaramiento plasmático más rápido, lo que podría suponer una ventaja en ciertos pacientes. Algunos estudios también sugieren que estas emulsiones podrían mejorar la función respiratoria. En general, estas ELIV que contienen AP son muy seguras, no aumentan el estrés oxidativo e incluso incrementan el nivel de alfa-tocoferol plasmático. Asimismo, no alteran la sensibilidad a la insulina o el control glicémico y tampoco se ha demostrado que afecten clínicamente a la agregación plaquetaria o a la hemostasia. En conclusión, el uso de ELIV con AP en la NP podría suponer algunas ventajas frente a la ELIV sin AP, además de la modulación de la respuesta infl amatoria sistémica. AbstractSeveral reviews and meta-analyses on modulated infl ammatory and immunologic responses after the administration of omega-3 polyunsaturated fatty acids (PUFAs) in different diseases and conditions have been published. However, omega-3 PUFAs exert several other actions which are not directly related to immunologic or infl ammatory responses. The aim of this paper was to review the effects which are not directly related to immunologic and infl ammatory responses of intravenous lipid emulsions (IVLEs) containing fi sh oil (FO) in parenteral nutrition (PN) for adult patients. IVLEs containing FO could have a role in the prevention of alterations in liver enzyme tests (LETs) or PN-associated liver disease (PNALD). Studies using FO doses of ≥ 0.150 mg/kg/day or IVLEs with high FO concentration reported more positive results than those with lower doses. Once PNALD was developed, the use of IVLEs exclusively composed of FO at doses of 0.25-1 g of FO/kg/day for several weeks could attenuate or even eradicate cholestasis and liver alteration. IVLEs containing FO seemed to have faster...

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Section: Potential Benefits Prevention Of Alterations In Liver Enzymementioning

confidence: 99%

Section: Potential Benefits Prevention Of Alterations In Liver Enzymementioning

confidence: 99%

Section: Potential Benefits Prevention Of Alterations In Liver Enzymementioning

confidence: 99%

“…Prospective studies collecting data on plasma clearance of IVLEs containing FO are presented in table II (6)(7)(8)(12)(13)(14)16,17,(19)(20)(21)(30)(31)(32)(33)(34).…”

Section: Plasma Lipid Clearancementioning

confidence: 99%

See 2 more Smart Citations

Effects unrelated to anti-inflammation of lipid emulsions containing fish oil in parenteral nutrition for adult patients

Joaquín¹,

Florit-Sureda²

2017

Nutr Hosp

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“…A third-generation lipid emulsion containing soybean, medium-chain triglyceride, olive and fish oils (SMOFlipid) resulted in favorable FA profiles (a desirable reduction in the ω-6/ω-3-FA ratio) 95 and retained hepatocellular integrity. 96 Small trials showed that fish oil-(ω-3) supplemented PN had anti-inflammatory and hepatoprotective effects in hyperinflammatory disease such as sepsis, 97 a beneficial effect on PN-associated liver disease, 98 reduced the Acute Physiology and Chronic Health Evaluation (APACHE) II and Simplified Acute Physiology Score II, as well as procalcitonin in sepsis. 92 However, clearly larger trials are required to confirm the findings or form the basis for recommendations in practice.…”

Section: Omega-3 Fatty Acids (Anti-inflammatory Nutrients)mentioning

confidence: 99%

Immunonutrition: a South African perspective

Prins

Visser

2012

South African Journal of Clinical Nutrition

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Lipid intensive drug therapy for sepsis pilot: A Bayesian phase I clinical trial

et al. 2020

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Comparison of the Effects of Different Intravenous Fat Emulsions in Patients With Systemic Inflammatory Response Syndrome and Sepsis

Abstract: Fish oil-based fat emulsions might have anti-inflammatory and hepatoprotective effects in hyperinflammatory disease such as sepsis.

Cited by 39 publications

References 29 publications

Effects unrelated to anti-inflammation of lipid emulsions containing fish oil in parenteral nutrition for adult patients

Effects unrelated to anti-inflammation of lipid emulsions containing fish oil in parenteral nutrition for adult patients

Immunonutrition: a South African perspective

Lipid intensive drug therapy for sepsis pilot: A Bayesian phase I clinical trial

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