Comparison of the Effects of T-1815, Yohimbine and Naloxone on Mouse Colonic Propulsion.

Yamada, Kenji; Onoda, Yuichi

doi:10.1540/jsmr.29.47

Cited by 35 publications

(36 citation statements)

References 9 publications

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“…and clonidine (mini mum effective dose=0.3 mg/kg, p.o.) induced constipa tion in mice (5). In the present study, T-1815 showed im proving effects in both the constipation models; however, the minimum effective doses for the loperamide and the clonidine-induced constipation were 100 mg/kg (p.o.)…”

contrasting

confidence: 49%

“…Colonic transport activ ity can be estimated by measuring the time required to ex crete a small ball inserted into the colon of mice or rats (2 5). A lag in the evacuation of the ball is known to be caused by the opioid agonist loperamide (5) and by the a2 adrenergic receptor agonist clonidine (4). In the present study, we examined whether administration of KW-5092 can restore the delayed colonic propulsion induced by loperamide or clonidine in rats by determining the evacu ation time of a teflon ball.…”

mentioning

confidence: 98%

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Effects of KW-5092, a Novel Gastroprokinetic Agent, on the Delayed Colonic Propulsion in Rats.

et al. 1994

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ABSTRACT-The effects of [1][2]fumarate, on the loperamide or clonidine-induced delayed propulsion were determined in rats and compared with those of other gastroprokinetic agents. Administration of loperamide (0.3 mg/kg, s.c.) or clonidine (0.01 mg/kg, s.c.) induced delay of the evacuation time of the teflon ball, which had been inserted into the distal colon. The delayed evacuation was improved dose dependently by KW-5092 at 3 to 10 mg/kg (p.o.) or higher. Neostigmine at 0.3 to 3 mg/kg (p.o.) and T-1815 at 1 to 100 mg/kg (p.o.) also improved the delayed ball evacuation. These results suggest that KW-5092 stimulates the delayed colonic propulsion.

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contrasting

confidence: 49%

mentioning

confidence: 98%

Effects of KW-5092, a Novel Gastroprokinetic Agent, on the Delayed Colonic Propulsion in Rats.

et al. 1994

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“…It causes constipation in animals by inhibiting intestinal water secretion (Hughes et al, 1984) and colonic peristalsis (Sohji et al, 1978) which consequentially affects the flow entering the colon (Lawrence et al 1986). These inhibitory activities extend fecal evacuation time and consequently delays intestinal luminal transit (Yamada and Onoda, 1993).…”

Section: Discussionmentioning

confidence: 99%

Effect of ethanolic seed extract of Croton penduliflorous Hutch. on loperamide-induced constipated male rats

Ashafa

Yakubu

Ogbe

et al. 2012

Bangladesh J Pharmacol

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“…Loperamide-induced constipation is a known and well-established model of spastic constipation (Yamada & Onoda 1993). It inhibits intestinal water secretion and colonic peristalsis which consequently delays faecal evacuation time and intestinal luminal transit (Schiller et al 1984).…”

Section: Laxative Activitymentioning

confidence: 99%

Toxicological implications and laxative potential of ethanol root extract ofMorella serratain loperamide-induced constipated Wistar rats

Sabiu

Ashafa

2016

Pharmaceutical Biology

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Context: Morella serrata L. (Myricaceae) is commonly used in South Africa to treat several diseases including constipation. Objectives: This study investigated toxicological implications and laxative potential of the ethanol root extract of the plant. Materials and methods: While normal control animals were placed on sterile placebo, the loperamideconstipated rats were treated with the extract at 75, 150 and 300 mg/kg doses for 7 days, and their feeding patterns and faecal properties were monitored. Gastrointestinal transit ratio and the toxicity profile of the tested doses were thereafter evaluated. Results: The significantly increased faecal volume (192.08%), feed (63.63%), water intake (55.97%) and improved intestinal motility (95.05%) in the constipated rats following treatment with the extract (at 300 mg/kg) suggested laxative potential of the extract. The 1.5-2.0-fold normalization of the platelets, erythrocytes and leukocytes counts in the extract-treated constipated rats suggests its non-haematotoxic tendency. Furthermore, the extract (at the highest investigated dose) reversed the attenuation in the concentrations of the electrolytes (0.5-2-fold), total protein (62.12%) and albumin (55.88%) in the constipated animals as well as attenuated activities of hepatic enzymes (0.5-3.0-fold) and levels of urea (126.67%), creatinine (40.32%), cholesterol (3-fold) and triglycerides (9-fold). These further support its non-toxic and therapeutic attributes against constipation. Conclusion: Overall, the effect exhibited by M. serrata in this study competed well with Senokot (standard drug) and proved that it may be relatively safe and with excellent laxative potential, thus, supporting its pharmacological applications in South Africa. ARTICLE HISTORY

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Comparison of the Effects of T-1815, Yohimbine and Naloxone on Mouse Colonic Propulsion.

Abstract: The colonic prokinetic activity of a newly synthesized compound,

Cited by 35 publications

References 9 publications

Effects of KW-5092, a Novel Gastroprokinetic Agent, on the Delayed Colonic Propulsion in Rats.

Effects of KW-5092, a Novel Gastroprokinetic Agent, on the Delayed Colonic Propulsion in Rats.

Effect of ethanolic seed extract of Croton penduliflorous Hutch. on loperamide-induced constipated male rats

Toxicological implications and laxative potential of ethanol root extract ofMorella serratain loperamide-induced constipated Wistar rats

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