Comparison of the effects of heparin 1000 and 5000 units on arterial blood gases

Abstract

Analysis of arterial blood gases is necessary for managing the respiratory and metabolic parameters of patients in the intensive care unit. The aim of this study was to compare the effects of heparin 1000 and heparin 5000 units on arterial blood gases in patients admitted to the intensive care unit. This study was a triple-blinded clinical trial. A total of 78 patients with head injury were randomly selected from the emergency department of a hospital in an urban area of Iran in 2017. Data was collected using a questionnaire and a checklist of laboratory parameters. Data was analyzed using descriptive and inferential statistical methods via the R software. Statistically significant differences in Na, SaO2, Ca, BEecf (p < 0.001), and HCO3, BEe and K were observed between the two groups (p < 0.01). No statistically significant difference between the values of PaCO2, PH and PaO2 in the two groups were reported (p > 0.05). The results of this study confirmed that heparin 1000 and heparin 5000 units had no effects on respiratory parameters in analyzing arterial blood gases. However, the concentration of heparin had a significant effect on metabolic parameters for the analysis of arterial blood gases and electrolytes.

The Effect of Heparin Concentration on Results of Venous Blood Gas of Patients admitted to Cardiac Intensive Care Unit: A double-blind clinical Trial

“…The heparin concentration and dilution in this study can be considered as a factor of insignificance of the statistical results of the hydrogen ion logarithm (PH), which was consistent with the previous studies [ 10 , 26 , 27 ], but inconsistent with studies by Coppola [ 28 ], Ashutosh Kumar [ 29 ], and Gholami [ 30 ] that suggested increasing heparin concentration had a significant effect on the results of hydrogen ion logarithm (PH). Despite the acidity of the heparin solution, the logarithm of the blood hydrogen ion (PH) is not affected by up to 40% heparin dilution due to the blood buffering capacity.…”

“…The results of this study show that increasing the heparin syringe concentration leads to a decrease in the parameters of PCO2, bicarbonate ion (HCO3), base excess (BE), which is consistent with the study by Gholami et al, Zokaei et al, Ashutosh Kumar et al, and Coppola et al[ 26 , 28 , 30 ] suggesting that increasing heparin concentration led to a decrease in bicarbonate ion (HCO3) and PCO2 parameters, but was not consistent with a study by Barabadi et al[ 10 ] suggesting that increasing heparin concentration had a significant effect on PCO2 parameter. Similarly, Gholami et al, Zokaie et al, and Barabadi et al showed that an increase in heparin concentration led to a decrease in BE parameter [ 10 , 26 , 30 ], which was consistent with the present study.…”

“…The effect of dilution and excess heparin concentration can reduce PCO2, which has the greatest effect. The concentration should be at least half the volume of different blood syringes, and all the heparin should be removed from the syringe [ 10 , 32 , 33 ]. In the present study, considering the control of dilution effects and confounding factors, the significance of the results of this parameter is probably due to higher heparin concentration in the heparin (5000 IU/mL) group.…”

“…In order to maintain the same condition, two blood samples were taken from the peripheral venous line in terms of all possible confounding factors and homogenization of the two groups. In this regard, after taking 1 cc (100 units) of blood sample using a 100-unit syringe, equal blood samples (0.5 cc or 50 units per syringe) were divided in two heparinized insulin syringes: A (heparin 1000 IU/ml) and B (heparin 5000 IU/ml) and then placed on ice and sent to the laboratory within 10 minutes [ 10 ] along with the test sheet, in which the necessary parameters (patient demographic characteristics, body temperature, hemoglobin level, oxygen intake) were recorded. It should be noted that only the researcher knew about the nature syringe codes and grouping.…”

“…The efficiency of this diagnostic tool depends on the sampling accuracy, the syringe volume, the amount of blood sample, the type and amount of heparin, storage, and timing of sending the sample to interpret the results correctly. Although previous studies have shown that heparin may lead to errors in the blood gas processing, it is still considered the only suitable anticoagulant in BG analysis [ 10 ].…”