Comparison of the effects of morphine administered by constant-rate intravenous infusion or intermittent intramuscular injection in dogs

Lucas, Anthony N.; Firth, Ava; Anderson, Garry A.; Vine, John; Edwards, Glenn A.

doi:10.2460/javma.2001.218.884

Cited by 68 publications

(92 citation statements)

References 10 publications

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“…Previous authors reported reduction in heart rate with use of morphine (LUCAS et al, 2001;WIESE;MARCH, 2003) and fentanyl (STEAGALL et al, 2006;BUFALARI et al, 2007;UEYAMA et al, 2009) CRIs. Steagall et al (2006) showed that hypertension spikes were avoided by fentanyl CRI administration in dogs, compared with a control group.…”

Section: Discussionmentioning

confidence: 99%

“…The doses and drugs evaluated in the records are already indicated for use in CRI and were in accordance with low doses described in the literature. These protocols are known to reduce the isoflurane requirement without adversely affecting hemodynamics or obvious adverse effects (LUCAS et al, 2001;WIESE;MARCH, 2003).…”

Section: Discussionmentioning

confidence: 99%

“…Depending on the procedure and drug combination, perioperative CRI can provide analgesia (LUCAS et al, 2001;WAGNER et al, 2002;BUFALARI et al, 2007;ORTEGA;CRUZ, 2011) and significantly decrease the minimum alveolar concentration (MAC) of inhaled anesthetics WIESE;MARCH, 2003;MATSUBARA et al, 2009;UEYAMA et al, 2009;AGUADO;BENITO;SEGURA, 2011), with minimal adverse effects.…”

Section: Introductionmentioning

confidence: 99%

“…The drugs most commonly administered by CRI are ketamine (SOLANO et al, 2006), lidocaine (ORTEGA;CRUZ, 2011), and opioid analgesics such as morphine (LUCAS et al, 2001) and fentanyl (UEYAMA et al, 2009). Ketamine is a noncompetitive antagonist of the N-methyl D-aspartate (NMDA) receptor and potentially has significant anti-hyperalgesic effects when administered by CRI.…”

Section: Introductionmentioning

confidence: 99%

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Effects of constant rate infusion of anesthetic or analgesic drugs on general anesthesia with isoflurane: A retrospective study in 200 dogs

et al. 2013

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Constant rate infusion (CRI) shows several advantages in balanced anesthesia, such as reduction of requirement for inhaled anesthetics and control of pain. The most commonly used drugs in these protocols are local anesthetics, dissociative, and opioids, which may be administered alone or in combinations. We evaluated the records of 200 dogs that underwent various surgical procedures with anesthetic or analgesic CRI in the perioperative period during 2011 and 2012 at the Veterinary Hospital of Franca University (Unifran), and identified possible complications during the transoperative period. Records evaluated included clinical state, laboratory tests, drugs used in premedication and induction, and CRI protocol. Acepromazine and morphine were the main drugs used in premedication. Propofol was used to induce anesthesia alone or in combination with other agents. We evaluated records of the 25 different CRI protocols. Fentanyl was the main drug employed in CRI, either alone or in combination. There were 128 episodes of anesthetic complications during CRI;the most common were hypotension, hypertension, and tachycardia, which occurred in 43 (32%), 35 (26.3%), and 19 (14.2%) dogs, respectively. Cardiac arrhythmia was reported in only 4 dogs. Signs of respiratory depression were present in dogs treated with 6 different CRI protocols. The consumption of isoflurane (vol %) reduced between 15.7% and 21.05% after 30minutes of the CRI in the fentanyl and fentanyl-lidocaine-ketamine CRI groups (p<0.05). In conclusion, CRI is a valid component of balanced anesthesia in dogs, safe, and has a low incidence of adverse effects. However, future studies are warranted to describe the results of the clinical use of CRI to better characterize and refine this technique. Key words: Continuous intravenous infusion, fentanyl, ketamine, lidocaine, morphine ResumoO uso de técnicas de infusão contínua (IC) possui inúmeras vantagens na anestesia balanceada, como a redução do requerimento de anestésicos inalatórios e controle da dor. Os fármacos mais comumente utilizados nestes protocolos são os anestésicos locais, dissociativos e opioides, que podem ser administrados isoladamente ou em associações. Foram avaliados os prontuários de 200 cães que foram submetidos a diversos procedimentos cirúrgicos com IC de anestésicos ou analgésicos no período perioperatório durante 2011 e 2012 no Hospital Veterinário da Universidade de Franca (Unifran). Foram identificadas possíveis complicações durante o período trans-operatório. Os registros avaliados incluíram estado clínico, exames laboratoriais, fármacos utilizados na pré-medicação e indução, e protocolos de IC. Acepromazina e morfina foram os principais fármacos usados na pré-medicação. O propofol foi utilizado para induzir a anestesia, isolado ou em associação com outros agentes. Foram avaliados os registros de 25 protocolos diferentes de IC. O fentanil foi o principal fármaco utilizado na IC, isoladamente ou em associação. Houve 128 episódios de complicações anestésicas durante a IC; os mais ...

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Effects of constant rate infusion of anesthetic or analgesic drugs on general anesthesia with isoflurane: A retrospective study in 200 dogs

et al. 2013

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“…It can contribute for minimizing hyperglycemia as well as the release of cortisol and catecholamines that happen in response to pain. This effect has been demonstrated in bitches premedicated with morphine and undergoing ovariohysterectomy or laparotomy (Lucas et al, 2001). The combination of morphine and local anesthetics through the epidural route can increase the duration of the block, as well as its analgesic efficacy.…”

Section: Introductionmentioning

confidence: 92%

Epidural levobupivacaine alone or combined with different morphine doses in bitches under continuous propofol infusion

Albuquerque¹,

Araújo²,

Ferreira³

et al. 2015

Arq. Bras. Med. Vet. Zootec.

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The aim of this study was to assess the cardiopulmonary, analgesic, adverse effects, serum concentration of cortisol and plasma levels of levobupivacaine and morphine in bitches undergoing propofol anesthesia and epidural analgesia with levobupivacaine alone or combined with morphine. This was a randomized 'blinded' prospective clinical study using 32 adult bitches weighing 9.8±4.1kg that were admitted for elective ovariohysterectomy. Twenty minutes after administration of acepromazine and midazolam, anesthesia was induced with propofol (4mg kg -1 ) and maintained by a continuous rate infusion (CRI). Each animal was randomly assigned to one of four epidural groups: GL = levobupivacaine alone (0.33mg kg -1 ); GLM0.1 = levobupivacaine and morphine (0.1mg kg -1 ); GLM0.15 = levobupivacaine and morphine (0.15mg kg -1 ); and GLM0.2 = levobupivacaine and morphine (0.2mg kg -1 ). Variables obtained during anesthesia were heart rate, respiratory rate, systolic, mean and diastolic arterial blood pressures, oxyhemoglobin saturation, inspired oxygen fraction, end-tidal carbon dioxide tension, blood gases, serum cortisol, and plasma levels of levobupivacaine and morphine. The onset and duration times of the blockade were recorded. Arterial pressures were significantly increased in all groups at the times of ovarian pedicle clamping. There was a decrease in pH, together with an increase in both PaO 2 and PaCO 2 over time. Serum cortisol levels were increased in TESu compared to TB, T30 and TR. Limb spasticity, muscle tremors, opisthotonos and diarrhea were observed in some animals during propofol infusion and ceased with the end of CRI. Reactions happened at different moments and lasted for different periods of time in each individual. Epidural with levobupivacaine alone or combined with morphine allowed for ovariohysterectomy to be performed under low propofol infusion rates, with minimal changes in cardiovascular variables and in serum cortisol levels. Adverse effects were observed in very few animals in each group. Keywords: dog, opioid, ovariohysterectomy, blood gas, regional anaesthesia (0,33mg/kg); GLM0,1 = levobupivacaína + morfina (0,1mg/kg); GLM0,15 = levobupivacaína + morfina (0,15mg/kg) e GLM0,2 = levobupivacaína + morfina (0,2mg/kg RESUMO Objetivou-se avaliar os efeitos cardiovasculares, analgésico, adversos, a concentração sérica de cortisol e os níveis plasmáticos de levobupivacaína e morfina em cadelas submetidas à infusão contínua de propofol e analgesia peridural com levobupivacaína isolada ou associada à morfina. Para tanto, realizou-se um estudo clínico prospectivo randomizado com 32 cadelas adultas pesando 9,8 ± 4,1kg, que foram submetidas à ovário-histerectomia eletiva. Vinte minutos após a administração de acepromazina e midazolam, os animais foram induzidos com propofol (4mg/kg) e mantidos por uma infusão contínua (CRI) do mesmo fármaco. Cada animal foi alocado aleatoriamente em um dos quatro grupos: GL = levobupivacaína isolada

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Pain Management in the Dental Patient

Steagall

Pascoe

2021

The Veterinary Dental Patient

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Comparison of the effects of morphine administered by constant-rate intravenous infusion or intermittent intramuscular injection in dogs

Cited by 68 publications

References 10 publications

Effects of constant rate infusion of anesthetic or analgesic drugs on general anesthesia with isoflurane: A retrospective study in 200 dogs

Effects of constant rate infusion of anesthetic or analgesic drugs on general anesthesia with isoflurane: A retrospective study in 200 dogs

Epidural levobupivacaine alone or combined with different morphine doses in bitches under continuous propofol infusion

Pain Management in the Dental Patient

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