Comparison of the effects of letrozole and clomiphene citrate on ovarian follicles, endometrium, and hormone levels in the rat

Kilic-Okman, Tulay; Küçük, Mustafa; Altaner, Semsi

doi:10.1016/j.fertnstert.2003.05.002

Cited by 40 publications

(32 citation statements)

References 18 publications

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“…Letrozole produces an estrogen-deficient environment by blocking the conversion of androgen to estrogen. The estrogen-deficient environment does not persist for long because these aromatase inhibitors have a short half-life (45 h) and are cleared from the body mainly by the liver (10).…”

mentioning

confidence: 99%

Effects of letrozole on bone biomarkers and femur fracture in female rats

et al. 2009

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We aimed to investigate the effects of the aromatase inhibitor letrozole on femur fracture and serum levels of alkaline phosphatase (ALP), calcium and phosphate in female rats. Intact 32 Sprague-Dawley female rats were divided into four groups (n=8): control, letrozole 0.2 , letrozole 1 (treatment of 0.2 and 1 mg/kg for six weeks) and recovery (letrozole-treated 1 mg/kg for six weeks then allowed to recover for two weeks). Besides, 24 ovariectomized rats were divided into three groups (n=8): ovariectomized+control, ovariectomized+letrozole and ovariectomized+letrozole+ estradiol (10 microg/rat). After experimental period, rats' femur bones were removed for biomechanical studies following decapitation. Serum ALP, calcium and phosphate were measured. Biomechanical values, ALP and phosphate significantly increased by letrozole in a dose-dependent manner (p<0.05) while calcium levels and net bone area decreased (p<0.05). Ultimate strength was positively correlated with ALP and phosphate and negatively correlated with calcium. The results indicate that letrozole may increase risk of bone fracture and affect bone biomarkers such as ALP, calcium and phosphate in both intact and ovariectomized rats.

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confidence: 99%

Effects of letrozole on bone biomarkers and femur fracture in female rats

et al. 2009

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“…Also, letrozole has a short half-life (45 h), so rapidly eliminated from the body (Mitwally and Casper, 2003;Kilic-Okman et al, 2003). In a study, it has concluded that letrozole gave a pregnancy rate of 20-27% per cycle in PCOS women resistant to CC.…”

Section: Discussionmentioning

confidence: 99%

A Clomiphene Citrate and Letrozol Varsus Tamoxifen and Letrozole as an Infertility Treatment in Women with Polycystic Ovary Syndrome

Athar¹,

Maalhagh²,

Hosseinpoor³

et al. 2015

Pakistan J. of Biological Sciences

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“…31 (4) In the Tulay Kilic-Okman et al 13 investigation, the effects of letrozole were compared to that caused by clomiphene citrate in rat ovarian follicles, endometrium and hormonal levels.…”

Section: Effect Of Letrozole In Carcinogen-plus-estrogen-induced Endomentioning

confidence: 99%

“…Aromatase inhibitors were developed as therapeutic effectors for estrogen-dependent cancers and are being used in malignant breast tumors in post-menopausal patients 13 .…”

Section: Introductionmentioning

confidence: 99%

Effect of letrozole in carcinogen-plus-estrogen-induced endometrial hyperplasia in mice

et al. 2016

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PURPOSE:To evaluate the effects of letrozole (Ltz) in carcinogen+estrogen-induced endometrial hyperplasia. METHODS:BALB/c female mice were divided into four groups of 12 animals each receiving an intrauterine dose of N-ethyl-Nnitrosourea (ENU) and weekly subcutaneous injections of estradiol hexaidrobenzoate (EHB), except for group I(control). The groups were divided in I (control), II (ENU+EHB), III (ENU+EHB+MPA) and IV (ENU+EHB+Ltz). Group III also received intramuscular injections of MPA (medroxy progesterone acetate) every four weeks, while group IV received oral doses of Ltz daily. At the end of 16 weeks, the animals were sacrificed, and blood samples were collected for the measurement of serum estradiol and progesterone levels.Uterine histological sections were made to evaluate the presence of endometrial proliferative lesions. Differences between groups were evaluated with student's t test, ANOVA and chi-square test. RESULTS:Groups ENU+EHB, ENU+EHB+MPA and ENU+EHB+Ltz showed varying degrees of endometrial hyperplasia. The incidence of hyperplasia in groups ENU+EHB and ENU+EHB+Ltz was higher and more severe than in group ENU+EHB+MPA.Control group showed lower levels of serum estradiol than the other groups. CONCLUSION:There was no evidence that letrozole could act as an antiestrogenic drug in the development of endometrial proliferative lesions.

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Comparison of the effects of letrozole and clomiphene citrate on ovarian follicles, endometrium, and hormone levels in the rat

Cited by 40 publications

References 18 publications

Effects of letrozole on bone biomarkers and femur fracture in female rats

Effects of letrozole on bone biomarkers and femur fracture in female rats

A Clomiphene Citrate and Letrozol Varsus Tamoxifen and Letrozole as an Infertility Treatment in Women with Polycystic Ovary Syndrome

Effect of letrozole in carcinogen-plus-estrogen-induced endometrial hyperplasia in mice

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