Comparison of the effects of amikacin and kanamycins A and B on dimyristoylphosphatidylglycerol bilayers

FTIR Study of the Monosialoganglioside GM1 in Perdeuterated Dimyristoylglycerophosphocholine (DMPCd54) Multilamellar Bilayers: Spectroscopic Evidence of a Significant Interaction between Ca2+ Ions and the Sialic Acid Moiety of GM1

“…1230 cm -1 for DMPC d54 / GM 1 bilayers (Figure 5, panel B) in the presence of the divalent cation. These Ca 2+ -induced changes of the phosphate band of DMPC d54 (Figure 5) are not as significant as the previously reported ones for dimyristoylglycerophosphoglycerol (DMPG): the asymmetric phosphate stretching band of DMPG shifted to lower frequencies by 2-8 cm -1 in the presence of cationic molecules(47,48).…”

Functional Properties of Maillard Reaction Products in Food: Antimicrobial Activity of Aminoreductone against Pathogenic Bacteria

“…In this study, PA and EC BL 21 showed resistance to three kinds of antibiotics (LVX, CIP, IPM) and MRSA demonstrated resistance to (Darville, 1999) or AN (Carrier et al, 1997) are widely used alone or in combination with other antimicrobial agents for the treatment of several serious infections caused by Gramnegative and -positive bacteria. Combined antibiotic therapy has been shown to delay the emergence of bacterial resistance and may also produce desirable synergistic effects in clinical settings (Adwan and Mhanna, 2008).…”

“…Thus, AR could be used either as an alternative antimicrobial agent or as an adjuvant therapy for infectious diseases. AN (amikacin), an aminoglycoside, inhibits protein synthesis by "irreversibly" binding to the 30S ribosomal subunit, thus preventing the formation of an initiation complex with messenger RNA (Carrier et al, 1997). Of the four antibiotics used, AN showed the highest inhibitory effect, similar to the effect of AR (except for MDRP), suggesting that AN could be used as a reliable reference during investigation of AR antimicrobial activity.…”

“…Of the four antibiotics used, AN showed the highest inhibitory effect, similar to the effect of AR (except for MDRP), suggesting that AN could be used as a reliable reference during investigation of AR antimicrobial activity. AN has been generally recognized to have some serious adverse effects, such as nephrotoxicity and permanent vestibular and/or auditory ototoxicity (Carrier et al, 1997); hence, the use of AR could be an appropriate alternative to AN. The fluoroquinolone antibacterial agents LVX and CIP (Mori et al, 2000), β-lactam antibiotics (IPM) function of AR might be due to the thickness of the bacterial cell wall, as well as the outer membrane-related components.…”

Membrane Interactions of Synthetic Peptides with Antimicrobial Potential: Effect of Electrostatic Interactions and Amphiphilicity

“…More specifically, increases of 11 and 16°C are observed with K5K10 and E5E10, respectively. There are other examples in the literature of molecules in interaction with anionic phospholipids that lead to an increase of the phase transition temperature of anionic phospholipids [28,29]. Stabilization of the charged phospholipids by charged peptides decreases the repulsion between phospholipids, thus stabilizing the gel phase.…”