Comparison of the effects of intravenous, enteral and enteral + intravenous supply of glutamine on malnutrition in sepsis

Koksal, GM; Karaören, Gülşah; Akarcay, H; Karabulut, E.; Tunalı, Yusuf; Vehid, Suphi; Öz, Hüseyin

doi:10.1186/cc9805

Cited by 3 publications

(3 citation statements)

References 1 publication

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“…In this recent study, lower age, higher PRISM-III and PELOD-II scores, higher dosages of vasopressor/inotropic support during the first 24 hours, prolonged MV duration, greater requirement of blood product transfusion, presence of trauma, nosocomial infection, VAP, thrombocytopenia, lower MAP and haemoglobin values, and leuko- cytosis during the first 24 hours were to be found mortality risk factors. Similar to other studies, in the present study, the mean age of the patients cared for in the aICU was (7.4 ± 5.4) years (10)(11)(12). The length of stay in the pICU was generally between 2 and 9.7 days in previous studies; it was similarly 6.6 ± 14.2 days in the present study (13)(14)(15).…”

Section: Discussionsupporting

confidence: 89%

“…It has been reported that the presence of chronic comorbidities in patients increases mortality and morbidity and prolongs the duration of hospital stay (26). In Turkey, the rate of accompanying chronic diseases, mostly neurological diseases, is 25.7 -61.7% in pICUs (12,19). In our study, the chronic comorbidity rate was identified in 76.2% of the patients admitted to the aICU.…”

Section: Discussionmentioning

confidence: 99%

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Evaluation of Critically Ill Paediatric Patients in the Adult ICU

Sevdi

Müslümanoğlu

2022

Iran J Pediatr

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Background: Critically ill paediatric patient (CIPP) care may be required in the adult intensive care unit (aICU) of hospitals in cases where there is no paediatric intensive care unit (pICU) or when the pICU bed capacity is insufficient. Objectives: This is a retrospective evaluation of CIPPs who were accommodated in aICUs over the last 10 years to determine the type of hospital admission, indications for hospitalization, presence of comorbidities, treatments, causes of mortality, and effects of these parameters on mortality. Methods: We retrospectively analysed the medical records of 600 patients aged 28 days to 17 years who had been cared for at least 24 hours in aICUs between 2011 and 2021. Results: The average age of the CIPPs ((252 female (42%), 348 male (58%)) was 6 (7.4 ± 5.4) years. The mortality rate was 14.7%, and trauma (31.8%) was the most common cause of mortality, followed by respiratory diseases and septic shock. The independent risk factors found to be associated with mortality were as follows: Lower age, admission to ICUs from emergency departments of hospitals, higher Pediatric Risk of Mortality III and Pediatric Logistic Organ Dysfunction II scores, duration of hospital stay and of mechanical ventilation, vasopressor/inotropic agent requirement in the first 24 hours, higher total transfusion requirement, presence of nosocomial infection, thrombocytopenia, and lower haemoglobin level. Conclusions: It is important to achieve the best results and better outcomes for CIPPs in pICUs. However, a significant proportion of CIPPs currently hospitalized in aICUs are admitted with trauma. A close follow-up of mortality scores and clinical parameters in the early period of CIPP care in the aICU is critical as some mortality risk factors are preventable.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 99%

Evaluation of Critically Ill Paediatric Patients in the Adult ICU

Sevdi

Müslümanoğlu

2022

Iran J Pediatr

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“…Glutamine can inhibit the expression of SIRT5 to inhibit the desuccinylation of pyruvate dehydrogenase (PDH), which leads to an increase in oxidative phosphorylation, thereby promoting M2 polarization of macrophages to reduce burn sepsis in mice [99]. In clinical trials, intravenous administration and enteral combined administration of glutamine effectively improved transferrin, creatine/height index, and nitrogen balance in patients with dystrophic sepsis, with the best effects on days 7 and 15 [100]. supplement, a reasonable dose of glutamine is considered safe [97].…”

Section: Amide Compoundsmentioning

confidence: 99%

Research Progress on Natural Small-Molecule Compounds for the Prevention and Treatment of Sepsis

Zhou

et al. 2023

IJMS

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Sepsis is a serious disease with high mortality and has been a hot research topic in medical research in recent years. With the continuous reporting of in-depth research on the pathological mechanisms of sepsis, various compounds have been developed to prevent and treat sepsis. Natural small-molecule compounds play vital roles in the prevention and treatment of sepsis; for example, compounds such as resveratrol, emodin, salidroside, ginsenoside, and others can modulate signaling through the NF-κB, STAT3, STAT1, PI3K, and other pathways to relieve the inflammatory response, immunosuppression, and organ failure caused by sepsis. Here, we discuss the functions and mechanisms of natural small-molecule compounds in preventing and treating sepsis. This review will lay the theoretical foundation for discovering new natural small-molecule compounds that can potentially prevent and treat sepsis.

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Glutamine supplementation for critically ill adults

Tao

Yang

et al. 2014

Cochrane Database of Systematic Reviews

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Analysis 2.1. Comparison 2 Glutamine-supplemented nutrition compared to non-supplemented nutrition (elective surgical patients versus critically ill patients), Outcome 1 Infectious complications.. .. .. .. .. .. .. Analysis 2.2. Comparison 2 Glutamine-supplemented nutrition compared to non-supplemented nutrition (elective surgical patients versus critically ill patients), Outcome 2 Short-term mortality (within hospital stay or ≤1 month).. Analysis 2.3. Comparison 2 Glutamine-supplemented nutrition compared to non-supplemented nutrition (elective surgical patients versus critically ill patients), Outcome 3 Long-term mortality (≥6 month

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Comparison of the effects of intravenous, enteral and enteral + intravenous supply of glutamine on malnutrition in sepsis

Cited by 3 publications

References 1 publication

Evaluation of Critically Ill Paediatric Patients in the Adult ICU

Evaluation of Critically Ill Paediatric Patients in the Adult ICU

Research Progress on Natural Small-Molecule Compounds for the Prevention and Treatment of Sepsis

Glutamine supplementation for critically ill adults

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