1997
DOI: 10.1128/aac.41.10.2089
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Comparison of the efficacies of various formulations of amphotericin B against murine visceral leishmaniasis

Abstract: The antileishmanial efficacies of four proprietary amphotericin B (AmB) formulations (Fungizone, AmBisome, Abelcet, and Amphocil) and an experimental nonionic surfactant vesicle (NIV) formulation were compared in a murine model of acute visceral leishmaniasis. By a multiple-dosing regimen, groups of Leishmania donovani-infected BALB/c mice were treated (2.5 mg of AmB per kg of body weight) on days 7 to 11 postinfection with one of the AmB formulations, and parasite burdens were determined on day 18 postinfecti… Show more

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Cited by 81 publications
(32 citation statements)
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“…It is also reported to be toxic to liver and heart (26,28). Therefore, the internal organs; brain, kidney, liver, heart, spleen and muscles of mice that received maximum tolerable dosage was observed for morphological changes.…”
Section: Resultsmentioning
confidence: 92%
“…It is also reported to be toxic to liver and heart (26,28). Therefore, the internal organs; brain, kidney, liver, heart, spleen and muscles of mice that received maximum tolerable dosage was observed for morphological changes.…”
Section: Resultsmentioning
confidence: 92%
“…Although it is unlikely that a therapeutic vaccine would be used alone [11], we set our criterion for success as inhibition of parasite growth of 50%. This level of response equates favorably to that seen following single dose therapy using 4 mg/kg Ambisome [26] or administration of sodium stibogluconate [27], although better responses are achievable with longer chemotherapy [26, 28]. Second, for clinical practicality, we aimed for efficacy using a single vaccination.…”
Section: Discussionmentioning
confidence: 99%
“…The decrease in activity as compared with free AmB and also the notable differences found among them (Yardley and Croft, 2000) was suggested as probably related to differences in their uptake and availability of the drug by the macrophages (Legrand et al, 1996). These effects were closely related to the strong interaction between the drug and the carrier compounds, that impaired the access of AmB inside the macrophages and the ability of the drug to interact with ergosterol in the parasite membrane (Müllen et al, 1997;Yardley and Croft, 2000). In our formulations, AmB was mainly adsorbed onto the carrier surface and desorption happens upon high dilution (concentrations below 1 mg/ml) (Espuelas et al, 1997;.…”
Section: Wild-typementioning
confidence: 91%