Comparison of the Efficacy and Tolerability of Dexketoprofen and Ketoprofen in the Treatment of Primary Dysmenorrhea

Abstract

Dexketoprofen, the pure S(+)-enantiomer of ketoprofen, is a promising new analgesic, but few clinical trials have yet examined its efficacy and tolerability. In this study, patients with a history of primary dysmenorrhea were treated with dexketoprofen doses of 12.5 and 25 mg, ketoprofen 50 mg, and placebo using a randomized, four-way crossover design. Efficacy analyses showed that dexketoprofen 12.5 and 25 mg and racemic ketoprofen 50 mg significantly reduced pain intensity compared with placebo from 1 h after dose to 4-6 h after dose. Interestingly, dexketoprofen at 12.5 mg was significantly superior to placebo at 30 min after dose. Mean pain relief scores also demonstrated that both doses of dexketoprofen and racemic ketoprofen were significantly superior to placebo at 1-6 h after the first dose. No indices of analgesic efficacy showed any significant differences between the two doses of dexketoprofen or between dexketoprofen and ketoprofen. After repeated dose administration, similar results were obtained. There were no significant effects of any treatment on activities of daily living, menstrual flow, or associated symptoms. Dexketoprofen was effective, well tolerated, and had no difference in the incidence of adverse events compared to ketoprofen or placebo.

Anaphylaxis after Intravenous Infusion of Dexketoprofen Trometamol

“…2e4 Parenterally or orally administered DT has a good tolerability profile and high analgesic potency. 1,8,9 Common adverse effects of DT include diarrhea, indigestion, nausea, stomach pain, and vomiting. 5 Besides nonspecific allergic reactions like dizziness, rash, skin eruptions, and vomiting, AS may also be seen.…”

Comparing Early Postoperative Period Analgesic Effect of Dexketoprofene Trometamol and Lornoxicam in Mediastinoscopy Cases

“…In one study, it was shown that the analgesic effect of dexketoprofen begins in 30 minutes, but the effect of ketoprofen takes longer to begin [10]. In animal studies, it has been shown that dexketoprofene is two times more potent than ketoprofen in its analgesic and anti-inflammatory effects [11].…”

“…In preclinical studies, although it is effective at very small doses, it is accepted that 25 mg of dexketoprofene is equal to 50 mg of dexketoprofene in certain clinical studies [12]. It was found that 25 mg of dexketoprofene is more effective than 12.5 mg, but there was no difference between 25 mg and 50 mg in analgesic effectiveness [10].…”

Treatment of Patient Syndrome at the Ambulatory-Polyclinic Stage. Selection of the Analgetic From the Positions of Comorbidity and Drug Safety: In Focus Dexketoprofen

“…По результатам исследо-ваний был сделан вывод, что анальгетическая эффек-тивность декскетопрофена в дозе 50 мг при почечной колике сравнима с таковой у рацемического кетопрофе-на в дозе 100 мг, а при внутривенном введении в дозе 25 и 50 мг эквивалентна применению метамизола натрия в дозировке 2000 мг. Эквивалентность декскето-профена в дозах 12,5/25 мг и 50 мг кетопрофена про-демонстрирована у пациенток с первичной дисменоре-ей [92], другое сравнение между 25 мг декскетопрофена с 50 мг кетопрофена у пациентов с остеоартритом пока-зало большую эффективность декскетопрофена [93]. В рандомизированном двойном слепом сравнительном исследовании применение декскетопрофена с целью обезболивания превосходило диклофенак при лито-трипсии камней мочеточника [94].…”