Comparison of the Efficacy of Two Lipid Emulsion Eyedrops in Increasing Tear Film Lipid Layer Thickness

Scaffidi, Robert C; Korb, Donald R.

doi:10.1097/01.icl.0000247638.50568.c0

Cited by 52 publications

(26 citation statements)

References 34 publications

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“…Our results are in good agreement with the results of Korb and others [11][12][13][14][15][16][17] that artificial tears containing phosphatidylcholine and other phospholipids strongly increase the thickness and the non-invasive break-up time of TF in vivo.…”

Section: Discussionsupporting

confidence: 92%

“…At present they are used as compounds of artificial tears (Tears Again, Soothe, Refresh Dry Eye Therapy, FreshKote, Refresh Endura) targeted to replenish the TF lipid layer of patients with Dry Eye Syndrome. Although the number of lipid-containing artificial tears on the market still remains relatively limited, in vivo studies demonstrated that formulations containing phospholipids and other PLs significantly increase the non-invasive break-up time of TF in laboratory animals and humans [11][12][13][14][15][16][17].…”

Section: Introductionmentioning

confidence: 99%

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Interactions of Meibomian gland secretion with polar lipids in Langmuir monolayers

Georgiev

Kutsarova

Jordanova

et al. 2010

Colloids and Surfaces B: Biointerfaces

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a b s t r a c tThe surface interactions of Meibomian gland secretion (MGS) with polar lipid (PL), Egg Sphingomyelin (SM) or Dipalmitoylphosphatidylcholine (DPPC), are studied in mixed pseudo-binary films formed at the air/water interface of Langmuir surface balance. The behavior of the mixed films during slow quasi-equilibrium compression and during fast dynamic compression-decompression is registered by measurements of surface pressure and surface potential, and by monitoring film morphology with Brewster Angle Microscopy (BAM). Quasi-equilibrium compression isotherms are used to calculate the excess Gibbs and Helmholtz energy of mixing between MGS and PLs and thus to evaluate the interactions between the lipid compounds at the interface. The effects of PLs on the mixed film's elastic moduli of area compressibility, morphology and capability to attain high surface pressures are also examined.PLs interact with MGS with different strength and in different manner: MGS-SM interaction is weak and might lead to interfacial disaggregation of the thick meibium domains when SM is in excess, while MGS-DPPC interaction is strong and results in the formation of thick lipid aggregates. Both PLs increase the mixed films reciprocal compressibility and capability to achieve higher surface pressures. The results demonstrate that in vitro studies of the surface interactions between MGS and PLs might be beneficial in the selection of PLs for artificial tear formulations and for examination on molecular scale of the possible role of PLs at the ocular surface.

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Interactions of Meibomian gland secretion with polar lipids in Langmuir monolayers

Georgiev

Kutsarova

Jordanova

et al. 2010

Colloids and Surfaces B: Biointerfaces

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show abstract

“…The product's viscosity is similar to that of tears (about 1.13 mm 2 /s) and thanks to the electrostatic attraction between the cationic emulsion and the ocular surface, the spreading upon instillation is optimal (surface tension of about 40 mN/m and spreading coefficient of about −10 mN/m). Thus the physicochemical properties of this cationic emulsion help meet the expected anti-evaporative, osmotic and rheological properties [8,13,17,18]. In contrast to benzalkonium chloride (BAK), used as a preservative in certain eye drops [19,20], this CKC-containing emulsion has additionally demonstrated excellent ocular tolerability, without any detergent properties, as animal studies have shown [13,21,22].…”

Section: Introductionmentioning

confidence: 99%

Ocular tolerability and efficacy of a cationic emulsion in patients with mild to moderate dry eye disease – A randomised comparative study

Amrane

Creuzot‐Garcher

Robert

et al. 2014

Journal Français d'Ophtalmologie

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“…One type of them is the lipid-containing artificial tears which help to 2 repair or improve the lipid layer present in the outermost part of the tear film, and some studies have been reported in literature [7,[16][17][18]. In these studies the artificial tears are used as eye drops.…”

Section: Introductionmentioning

confidence: 99%

Langmuir films study on lipid-containing artificial tears

Torrent‐Burgués

2016

Colloids and Surfaces B: Biointerfaces

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Lipid-containing artificial tears are a type of artificial tears that use lipid components in order to restore the lipid layer of the tear film. One of these components is lecithin which can be applied in spray solutions containing lecithin liposomes. In this work the behavior of three of these commercial tears based on lecithin, Innoxa, Opticalm and Optrex, are studied using the Langmuir technique. The obtained isotherms are presented, discussed and compared. This technique seems useful in order to see the film behavior of the lipid components of these tears and determine some important parameters such as fluidity and extension at the air-water interface, and allows us to discern differences between these commercial tears. Innoxa and Optrex tears are more similar to each other than to Opticalm tears. Opticalm presents more fluidity, probably due to the presence of more insaturations in the fatty acid chains of the phospholipids of the lecithin used in fabrication.

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Comparison of the Efficacy of Two Lipid Emulsion Eyedrops in Increasing Tear Film Lipid Layer Thickness

Cited by 52 publications

References 34 publications

Interactions of Meibomian gland secretion with polar lipids in Langmuir monolayers

Interactions of Meibomian gland secretion with polar lipids in Langmuir monolayers

Ocular tolerability and efficacy of a cationic emulsion in patients with mild to moderate dry eye disease – A randomised comparative study

Langmuir films study on lipid-containing artificial tears

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