Comparison of the efficacy of low-level laser therapy and photodynamic therapy on oral mucositis in rats

Alinca, Suzan Bayer; Sağlam, Ebru; Kandaş, Nur Özten; Okçu, Oğuzhan; Yılmaz, Nergiz; Göncü, Beyza; Doğan, Mehmet Ali

doi:10.1007/s10103-019-02757-w

Cited by 17 publications

(14 citation statements)

References 43 publications

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“…39 In a comparison between LLLT and photodynamic therapy (PDT) treatment using indocyanine green (ICG), ICG has been found to possibly accelerate the effects provided by LLLT. 40 From the 12 clinical studies, 8 utilized LLLT/ PBM while the remaining 4 made use of photosensitizers or other treatment groups (Table 2). Application of LLLT/ PBM as either a prophylactic against OM before chemo and/or radiotherapy or as a treatment for OM have been conducted and results indicated that it was effective in preventing OM, OM grade reduction, and OM pain management.…”

Section: Resultsmentioning

confidence: 99%

“…The protocols of intraoral and extraoral irradiation have positive effect but the most effective protocol is the extraoral 6.11 J/cm 2 Alinca et al 40 (2019) decade to verify the effect of LLLT/PBT treatment on the recovery of chemotherapy-induced oral mucositis. Six animal studies were reviewed for the treatment of chemotherapy-induced oral mucositis and 12 human studies were reviewed for the treatment of chemotherapy and/ or radiotherapy-induced oral mucositis.…”

Section: Discussionmentioning

confidence: 99%

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Decade Long Survey of Low-level Laser Therapy/Photobiomodulation (LLLT/PBM) Therapy for Oral Mucositis Treatment

et al. 2021

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Low-level laser therapy or photobiomodulation (LLLT/PBM) therapy has been widely applied to enhance and accelerate the recovery of oral mucositis. This study investigates the documented effect of LLLT on oral mucositis caused by chemotherapy. This review appraises 6 animal studies and 12 clinical studies published in the Pubmed database during the past 10 years, related to the application of LLLT for the treatment of mucositis. Despite varied parameters and diverse conditions, the assessed articles indicate that application of LLLT on oral mucositis using near-infrared wavelengths is prophylactic, reduces pain, and enables a rapid recovery. Various combined treatments were also identified among the published papers, which further establishes the efficacy of LLLT as a viable treatment.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Decade Long Survey of Low-level Laser Therapy/Photobiomodulation (LLLT/PBM) Therapy for Oral Mucositis Treatment

et al. 2021

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“…Application of photodynamic therapy for treatment of open excision wounds, skin abrasion, punch biopsies, chronic leg, and diabetic foot ulcers also accelerated the wound healing process in comparison with untreated wounds 30‐33 . Alinca et al, 34 also suggest that low‐level laser therapy with ICG might accelerate the healing effect of oral mucositis in rats.…”

Section: Discussionmentioning

confidence: 98%

Photodynamic antimicrobial chemotherapy using indocyanine green in experimentally induced intraoral ulcers in rats

Motamedifar

Tanideh

Mardani

et al. 2020

Photoderm Photoimm Photomed

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Background Photodynamic antimicrobial chemotherapy (PACT) is a promising modality for eradication of microorganisms from the wound. This study aimed to investigate the effectiveness of PACT using indocyanine green (ICG) for reduction of bacterial load of oral ulcers in rats and its impact on the healing process. Methods In this experimental study, 50 adult male Sprague Dawley rats were recruited. Oral ulcers were surgically made on the left cheek mucosa, and animals were randomly assigned into five groups (n = 10). Wound site in groups 1, 2, and 3 was irrigated with the sterile saline (0.9%), chlorhexidine (CHX; 0.2%), and ICG solutions (1 mg/mL), respectively. Group 4 was exposed to laser irradiation using 810 nm diode laser on continuous‐wave mode for 30 seconds (fluence: 55 J/cm2, power: 300 mW, spot size: 4.5 mm). In group 5, PACT was performed using topical application of ICG followed by laser irradiation in the same way as the previous group. Bacterial load of oral ulcers was assessed before and after each treatment modality. Besides, rats were sacrificed on the 5th day post ulceration and histological features of healing were evaluated. Results Bacterial load was significantly reduced merely in the PACT‐ICG‐treated group by one log (P < .0001). Animals in the PACT‐ICG‐treated group also showed an accelerated healing in comparison with others on the 5th day of an experiment. Conclusion Photodynamic antimicrobial chemotherapy using topical application of ICG has a potential to reduce the bacterial load of oral ulcers and accelerate wound repair. Therefore, it can be considered as an alternative to currently available modalities for wound management.

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“…In particular, eating cold, hot, acidic and irritant foods often causes severe pain, which seriously affects quality of life [ 26 ]. Many interventions have been developed to treat oral mucositis, such as oral zinc sulphate, chlorhexidine, honey and laser therapy [ 27 – 29 ]. However, these interventions will bring additional pain to the patients.…”

Section: Discussionmentioning

confidence: 99%

Nattokinase crude extract enhances oral mucositis healing

et al. 2021

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Background Nattokinase (NK) is a promising alternative in the prevention and treatment of cardiovascular diseases due to its potent fibrinolytic activity. In this study, we investigated the effect of crude nattokinase extract on the healing of acetic acid-induced oral mucositis in mice. Methods Bacillus subtilis culture media (BSCM) was isolated into the supernatant, named nattokinase crude extract (NCE), and the pellet was named Bacillus subtilis mass (BSM). An oral mucositis model was established in mice by applying 50% glacial acetic acid to the buccal mucosa. According to the treatment conditions, the mice were divided into BSCM, NCE, BSM and phosphate buffered saline (PBS) groups. The weight of the mice, oral mucositis healing score and histopathological examination were used to evaluate the treatment. Results Fibrinolytic activities of BSCM, NCE and BSM were approximately 8069, 10,800 and 80 U/ml, respectively. The weight gain of mice in the NCE group was significantly different from the PBS group after three days’ treatment (p < 0.05). The oral mucositis score of NCE group was significantly higher than other groups (p < 0.05). The differences in histopathology scores between the NCE and other groups were statistically significant (p < 0.01). Conclusions NCE could possess remarkable potential to reduce pain and promote oral mucositis healing with minimal safety concerns. In this study, we first report that NCE from the supernatant of Bacillus subtilis can promote the healing of oral mucositis, which extends the application scope of NK.

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Comparison of the efficacy of low-level laser therapy and photodynamic therapy on oral mucositis in rats

Cited by 17 publications

References 43 publications

Decade Long Survey of Low-level Laser Therapy/Photobiomodulation (LLLT/PBM) Therapy for Oral Mucositis Treatment

Decade Long Survey of Low-level Laser Therapy/Photobiomodulation (LLLT/PBM) Therapy for Oral Mucositis Treatment

Photodynamic antimicrobial chemotherapy using indocyanine green in experimentally induced intraoral ulcers in rats

Nattokinase crude extract enhances oral mucositis healing

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