Comparison of the efficacy of ALA‐PDT using an excimer‐dye laser (630 nm) and a metal‐halide lamp (600 to 740 nm) for treatment of Bowen's disease

Abstract

A novel protocol for topical ALA-PDT in Japanese in Asian patients with BD was developed and implemented. The protocol improved the CR rate compared with previous studies. Moreover, the present results indicate that the efficacy of topical ALA-PDT using MHL was superior to that using EDL for BD patients.

A randomized trial comparing methyl aminolaevulinate photodynamic therapy with and without Er:YAG ablative fractional laser treatment in Asian patients with lower extremity Bowen disease: results from a 12-month follow-up

“…This result is slightly lower than that at 3 months in previous studies with white subjects, which have shown rates of 73–93% for BD lesions of the face, scalp, neck, trunk and extremities . Few studies have investigated the efficacy of ALA‐PDT for treating BD among darker‐skinned ethnic groups . Mizutani et al .…”

“…[23][24][25][26] Few studies have investigated the efficacy of ALA-PDT for treating BD among darker-skinned ethnic groups. 27,28 Mizutani et al 27 showed that ALA-PDT using an excimer-dye laser (630 nm) was effective for the treatment of BD in Asians; however, they required three treatment sessions to achieve a similar efficacy as that in white subjects with only two sessions. Another Asian study reported an ALA-PDT efficacy of 80% with two to four sessions.…”

Spotlighting the Role of Photodynamic Therapy in Cutaneous Malignancy: An Update and Expansion

“…2 PDT has been studied in open and randomized trials for the treatment of Bowen's disease of the extremities, scalp, face, and trunk. 28 PDT was superior to cryotherapy and 5-fluorouracil with regard to pain tolerance and cosmetic outcomes and should be considered a viable option for Bowen's disease as tissue-sparing, noninvasive therapy. Table 2 summarizes clinical trials and case series presented since 2007 on PDT treatment of Bowen's disease.…”

“…Recent studies have compared excimer dye and metal halide light sources and red and green light, but the literature is consistent that depth of light penetration correlates with clearance rate. 28 PDT was superior to cryotherapy and 5-fluorouracil with regard to pain tolerance and cosmetic outcomes and should be considered a viable option for Bowen's disease as tissue-sparing, noninvasive therapy. 5 It may even be considered as first-line therapy for large or widespread lesions or those in difficult to treat areas.…”

British Association of Dermatologists and British Photodermatology Group guidelines for topical photodynamic therapy 2018

“…Fluorescent lamps with an emission spectrum between 400 and 450 nm are also used for PDT of AK. There are numerous publications describing the use of other light sources including dye lasers and intense pulsed light . In the case of MAL‐PDT, standard procedures involve the use of LEDs .…”