Comparison of the expression levels of TNF-Î±, IL-6, hsCRP and sICAM-1 inflammatory factors, bone mineral density and nutritional status between diabetic and normal pregnant women

Wang, Qian; Wang, Chun

doi:10.14715/cmb/2020.66.3.20

Cited by 12 publications

(7 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…17 In our study, the BMD of the GDM group was lower than that of the healthy population, but there was no statistical difference in calcium content between the two groups, which does not exclude statistical error and is also related to the small sample size included in this study. Wang Q et al 18 found in their study that the BMD of pregnant women with GDM was significantly lower than that of pregnant women with normal blood glucose, and believed that prevention of GDM in pregnant women was crucial for their bone health, which was similar to the results of this study. We found that there was a negative correlation between serum 25-hydroxyVitamin-D, PTH and BMD in the GDM group which was similar to the research results of Kramer et al 19 This may be attributed to the metabolic environment in pregnant women, in order to meet the growth and development of the fetus, regulating the increase of parathyroid hormone secretion, increasing the number of osteoclasts, promoting the dissolution of bone salts, bone calcium into the blood to supply nutrients needed for fetal growth, leading to the reduction of bone mineral density.…”

Section: A H E a D O F P R I N Tsupporting

confidence: 87%

Evaluation of bone mineral density in patients with gestational diabetes mellitus by ultrasonic bone mineral density measurement combined with Vitamin-D deficiency and analysis of influencing factors

Han¹,

Ma²,

Wang³

et al. 2022

Pak J Med Sci

View full text Add to dashboard Cite

Objectives: To investigate the evaluation of bone mineral density (BMD) in patients with gestational diabetes mellitus (GDM) by ultrasonic bone mineral density measurement combined with Vitamin-D deficiency and its influencing factors. Methods: A total of 100 patients with gestational diabetes mellitus (GDM) admitted to our hospital from January 2017 to December 2020 were selected as the GDM group, and another 100 pregnant volunteers who underwent physical examination in our hospital were selected as the healthy control group. The levels of triacylglycerol (TG), total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), glycated hemoglobin (HbA1c), fasting insulin (FINS), C-peptide, procollagen, parathyroid hormone (PTH), serum calcium, 25-hydroxyvitamin-D3 (25-OH-D) and ultrasonic BMD Z-score were determined and compared between the two groups. Moreover, the effects of different levels of 25-OH-D on the above indexes were compared, and multivariate logistic regression analysis was performed. Results: Compared with the healthy reference group, the levels of TG, TC, LDL-C, PTH, HbA1c, FINS and C-peptide of GDM group were significantly increased (P < 0.05), while BMD Z-score and 25-OH-D levels were significantly decreased. In the GDM group, the lower the 25-OH-D levels, the higher the FPG, HbA1c and FINS levels and the lower the serum calcium level and BMD Z-score, with statistically significant differences (P < 0.05). Multivariate logistic regression analysis showed that 25-OH-D was an independent risk factor affecting BMD in patients with GDM (P<0.05). Conclusions: Patients with GDM have lower BMD and 25-hydroxyVitamin-D3 levels. Measurement of BMD and 25-hydroxyVitamin-D3 levels can help assess the progression of GDM. BMD has a close bearing on Vitamin-D deficiency in patients with GDM. doi: https://doi.org/10.12669/pjms.38.4.5090 How to cite this:Han L, Ma J, Wang S, Li Z. Evaluation of bone mineral density in patients with gestational diabetes mellitus by ultrasonic bone mineral density measurement combined with Vitamin-D deficiency and analysis of influencing factors. Pak J Med Sci. 2022;38(4):---------. doi: https://doi.org/10.12669/pjms.38.4.5090 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

show abstract

Section: A H E a D O F P R I N Tsupporting

confidence: 87%

Evaluation of bone mineral density in patients with gestational diabetes mellitus by ultrasonic bone mineral density measurement combined with Vitamin-D deficiency and analysis of influencing factors

Han¹,

Ma²,

Wang³

et al. 2022

Pak J Med Sci

View full text Add to dashboard Cite

show abstract

“…The expression of cytokines, as well as the resulting immune response, may also be the result of cytokine gene polymorphism. Thus, cytokine gene polymorphisms can potentially contribute to the risk of recurrent miscarriage, especially gene polymorphisms associated with pro-inflammatory cytokines such as TNF-α, Il-1, Il-6, and IFNG [ 11 , 12 , 13 , 14 , 15 ]. TNF-α may directly promote tissue damage in pregnancy, as suggested by in vitro studies where TNF-α activated maternal monocytes bound to LFA-1 on placental syncytiotrophoblasts and induced apoptosis [ 16 ].…”

Section: The Role Of Tnf-α In Pregnancymentioning

confidence: 99%

The Role of TNF-α and Anti-TNF-α Agents during Preconception, Pregnancy, and Breastfeeding

Romanowska-Próchnicka

Felis-Giemza

Olesińska

et al. 2021

IJMS

View full text Add to dashboard Cite

Tumor necrosis factor-alpha (TNF-α) is a multifunctional Th1 cytokine and one of the most important inflammatory cytokines. In pregnancy, TNF-α influences hormone synthesis, placental architecture, and embryonic development. It was also shown that increased levels of TNF-α are associated with pregnancy loss and preeclampsia. Increased TNF-α levels in complicated pregnancy draw attention to trophoblast biology, especially migratory activity, syncytialisation, and endocrine function. Additionally, elevated TNF-α levels may affect the maternal-fetal relationship by altering the secretory profile of placental immunomodulatory factors, which in turn affects maternal immune cells. There is growing evidence that metabolic/pro-inflammatory cytokines can program early placental functions and growth in the first trimester of pregnancy. Furthermore, early pregnancy placenta has a direct impact on fetal development and maternal immune system diseases that release inflammatory (e.g., TNF-α) and immunomodulatory factors, such as chronic inflammatory rheumatic, gastroenterological, or dermatological diseases, and may result in an abnormal release of cytokines and chemokines in syncytiotrophoblasts. Pregnancy poses a challenge in the treatment of chronic disease in patients who plan to have children. The activity of the disease, the impact of pregnancy on the course of the disease, and the safety of pharmacotherapy, including anti-rheumatic agents, in pregnancy should be considered.

show abstract

“…Also, the average age and gestational age in this study are smaller than in the study Persico et al (28) . There are several reports related to the effect on the mood and mood of pregnant women, which needs more research (29)(30)(31)(32)(33)(34)(35) .…”

Section: Discussionmentioning

confidence: 99%

The Effect of Music on The Level of Happiness in Primigravida Women

Hoorijani¹,

Manouchehri²,

Faridi³

et al. 2023

The Egyptian Journal of Hospital Medicine

View full text Add to dashboard Cite

Background: A woman's subjective happiness is an important predictor of her adjustment to pregnancy. The emotional response and level of happiness of women during pregnancy have a great impact on the continuation of pregnancy and health behaviors during this period. Objective: This study was conducted to investigate the effect of music on the level of happiness in primigravida women. Patients and methods:The present research is a clinical trial with a pre-test, a post-test, a follow-up, and a control group. The research population included all primigravida women who were referred to the comprehensive health Centers in the city of Sanandaj in the year 2020. A total of 30 primigravida women were selected using a simple random sampling method and were randomly assigned to the experimental group and the control group. The experimental group listened to music by Kitaro for 45 minutes every night before going to bed for a period of 4 weeks. The Oxford Happiness Questionnaire and a checklist for listening to the music were used to collect data. Results:The mean score for happiness in the experimental group increased in the post-test compared with the pretest, but the difference was not significant. However, there was a significant difference between the mean scores for the pre-test and the follow-up stages (p<0.01). The results of the study showed that music can increase the level of happiness in pregnant women. Conclusions: Music could be used by healthcare workers in comprehensive health centers in order to improve happiness in pregnant women.

show abstract

Comparison of the expression levels of TNF-Î±, IL-6, hsCRP and sICAM-1 inflammatory factors, bone mineral density and nutritional status between diabetic and normal pregnant women

Cited by 12 publications

References 33 publications

Evaluation of bone mineral density in patients with gestational diabetes mellitus by ultrasonic bone mineral density measurement combined with Vitamin-D deficiency and analysis of influencing factors

Evaluation of bone mineral density in patients with gestational diabetes mellitus by ultrasonic bone mineral density measurement combined with Vitamin-D deficiency and analysis of influencing factors

The Role of TNF-α and Anti-TNF-α Agents during Preconception, Pregnancy, and Breastfeeding

The Effect of Music on The Level of Happiness in Primigravida Women

Contact Info

Product

Resources

About